Muricenones A and B: New degraded pregnanes from a gorgonian of the genus Muricea
The gorgonian Muricea sp. contains two new degraded pregnanes, muricenones A (1) and B (2), whose structures have been defined by spectroscopic analysis. The uncommon carbon framework of muricenones may be biosynthetically derived by oxidative cleavage and loss of one carbon atom of the A-ring of th...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2002 |
| País: | México |
| Institución: | Universidad Nacional Autónoma de México |
| Repositorio: | Sistema de Información de la Facultad de Ciencias, UNAM |
| OAI Identifier: | oai:repositorio.fciencias.unam.mx:11154/2509 |
| Acceso en línea: | http://hdl.handle.net/11154/2509 |
| Access Level: | acceso abierto |
| Palabra clave: | Chemistry, Organic natural products octocorals steroids structure elucidation cytotoxicity |
| Sumario: | The gorgonian Muricea sp. contains two new degraded pregnanes, muricenones A (1) and B (2), whose structures have been defined by spectroscopic analysis. The uncommon carbon framework of muricenones may be biosynthetically derived by oxidative cleavage and loss of one carbon atom of the A-ring of the steroidal nucleus. The new compounds, I and 2, isolated from Muricea sp., selectively inhibit the growth of the A-549 human lung carcinoma cell line. ((C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002). |
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