Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease

Genetic variants have been associated with diseases of complex traits and risk factors associated to them. The purpose of this study was to evaluate the association between several Single Nucleotide Polymorphisms (SNPs) with metabolic syndrome (MetS) and the atherogenic index of plasma (AIP). Guerre...

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Autores: Flores-Alfaro, Eugenia, Cruz-López, Miguel, Alarcón-Romero, Luz del Carmen, Moreno-Godínez, María Elena, del Moral-Hernández, Oscar, Vences-Velázquez, Amalia, Ortuño-Pineda, Carlos, Leyva-Vázquez, Marco Antonio, Tello-Flores, Vianet Argelia, Cahua-Pablo, José Ángel, Antúnez-Ortiz, Diana Lizzete, Méndez-Palacios, Abigail, Valladares-Salgado, Adán
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:México
Institución:UNIVERSIDAD DE GUANAJUATO
Repositorio:Acta Universitaria
Idioma:español
OAI Identifier:oai:www.actauniversitaria.ugto.mx:article/751
Acceso en línea:https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/751
Access Level:acceso abierto
Palabra clave:Adiponectin
atherogenic risk
metabolic syndrome
SNPs.
Adiponectina
riesgo aterogénico
síndrome metabólico
SNP.
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spelling Genetic markers associated with the development of metabolic syndrome and risk of coronary heart diseaseMarcadores genéticos relacionados con el desarrollo de síndrome metabólico y riesgo de enfermedad coronaria cardiacaFlores-Alfaro, EugeniaCruz-López, MiguelAlarcón-Romero, Luz del CarmenMoreno-Godínez, María Elenadel Moral-Hernández, OscarVences-Velázquez, AmaliaOrtuño-Pineda, CarlosLeyva-Vázquez, Marco AntonioTello-Flores, Vianet ArgeliaCahua-Pablo, José ÁngelAntúnez-Ortiz, Diana LizzeteMéndez-Palacios, AbigailValladares-Salgado, AdánAdiponectinatherogenic riskmetabolic syndromeSNPs.Adiponectinariesgo aterogénicosíndrome metabólicoSNP.Genetic variants have been associated with diseases of complex traits and risk factors associated to them. The purpose of this study was to evaluate the association between several Single Nucleotide Polymorphisms (SNPs) with metabolic syndrome (MetS) and the atherogenic index of plasma (AIP). Guerrero women were studied. Somatometric measurements were performed, and blood biomarkers were determined. SNPs were identified in seven genes by real-time polymerase chain reaction (PCR). Decreased adiponectin in women with MetS and with greater atherogenic risk was observed, and associations between APOE with elevated levels of low-density lipoprotein (LDL)-cholesterol and triglycerides, the SNPrs1501299 with the AIP, the AA/rs708272 and GG/rs1884051 genotypes, with high LDL levels and genotype AA/rs854560 with LDL-c and paraoxonase activity. The results indicate that blood and genetic biomarkers might be involved in metabolic alterations and thus increase the individual's risk for disease development. Variantes genéticas se han relacionado con enfermedades de rasgos complejos y factores de riesgo asociados a éstas. El propósito de este estudio fue evaluar la asociación entre diversos polimorfismos de un solo nucleótido (SNP, por sus siglas en inglés) con el síndrome metabólico (SM) y con el índice aterogénico de plasma (IAP). Se estudiaron mujeres guerrerenses, a quienes se les realizaron mediciones somatométricas, biomarcadores sanguíneos y se identificaron SNP en siete genes por reacción en cadena de la polimerasa (PCR, por sus siglas en inglés) en tiempo real. Se observó disminución de adiponectina en mujeres con SM y con el mayor riesgo aterogénico, y se encontraron asociaciones entre apoproteina E (APOE) con niveles elevados de lipoproteínas de baja densidad (LDL, por sus siglas en inglés) y triglicéridos, del SNP rs1501299 con el IAP, de los genotipos AA/rs708272 y GG/rs1884051, con los niveles altos de LDL, y del genotipo AA/rs854560 con LDL y con la actividad paraoxonasa. Los resultados indican que biomarcadores sanguíneos y genéticos pudiesen estar implicados en alteraciones metabólicas y, por tanto, incrementar el riesgo individual del desarrollo de enfermedades. Universidad de Guanajuato2015-07-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículo revisado por paresapplication/pdftext/htmlhttps://www.actauniversitaria.ugto.mx/index.php/acta/article/view/75110.15174/au.2015.751Acta Universitaria; Vol. 25 (2015): (NE-1) Ciencias Médicas; 9-13Acta Universitaria; Vol. 25 (2015): (NE-1) Ciencias Médicas; 9-132007-96210188-6266reponame:Acta Universitariainstname:UNIVERSIDAD DE GUANAJUATOinstacron:UGTOspahttps://www.actauniversitaria.ugto.mx/index.php/acta/article/view/751/pdf_81https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/751/html_74info:eu-repo/semantics/openAccessoai:www.actauniversitaria.ugto.mx:article/7512024-08-16T21:06:32Z
dc.title.none.fl_str_mv Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
Marcadores genéticos relacionados con el desarrollo de síndrome metabólico y riesgo de enfermedad coronaria cardiaca
title Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
spellingShingle Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
Flores-Alfaro, Eugenia
Adiponectin
atherogenic risk
metabolic syndrome
SNPs.
Adiponectina
riesgo aterogénico
síndrome metabólico
SNP.
title_short Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
title_full Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
title_fullStr Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
title_full_unstemmed Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
title_sort Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease
dc.creator.none.fl_str_mv Flores-Alfaro, Eugenia
Cruz-López, Miguel
Alarcón-Romero, Luz del Carmen
Moreno-Godínez, María Elena
del Moral-Hernández, Oscar
Vences-Velázquez, Amalia
Ortuño-Pineda, Carlos
Leyva-Vázquez, Marco Antonio
Tello-Flores, Vianet Argelia
Cahua-Pablo, José Ángel
Antúnez-Ortiz, Diana Lizzete
Méndez-Palacios, Abigail
Valladares-Salgado, Adán
author Flores-Alfaro, Eugenia
author_facet Flores-Alfaro, Eugenia
Cruz-López, Miguel
Alarcón-Romero, Luz del Carmen
Moreno-Godínez, María Elena
del Moral-Hernández, Oscar
Vences-Velázquez, Amalia
Ortuño-Pineda, Carlos
Leyva-Vázquez, Marco Antonio
Tello-Flores, Vianet Argelia
Cahua-Pablo, José Ángel
Antúnez-Ortiz, Diana Lizzete
Méndez-Palacios, Abigail
Valladares-Salgado, Adán
author_role author
author2 Cruz-López, Miguel
Alarcón-Romero, Luz del Carmen
Moreno-Godínez, María Elena
del Moral-Hernández, Oscar
Vences-Velázquez, Amalia
Ortuño-Pineda, Carlos
Leyva-Vázquez, Marco Antonio
Tello-Flores, Vianet Argelia
Cahua-Pablo, José Ángel
Antúnez-Ortiz, Diana Lizzete
Méndez-Palacios, Abigail
Valladares-Salgado, Adán
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adiponectin
atherogenic risk
metabolic syndrome
SNPs.
Adiponectina
riesgo aterogénico
síndrome metabólico
SNP.
topic Adiponectin
atherogenic risk
metabolic syndrome
SNPs.
Adiponectina
riesgo aterogénico
síndrome metabólico
SNP.
description Genetic variants have been associated with diseases of complex traits and risk factors associated to them. The purpose of this study was to evaluate the association between several Single Nucleotide Polymorphisms (SNPs) with metabolic syndrome (MetS) and the atherogenic index of plasma (AIP). Guerrero women were studied. Somatometric measurements were performed, and blood biomarkers were determined. SNPs were identified in seven genes by real-time polymerase chain reaction (PCR). Decreased adiponectin in women with MetS and with greater atherogenic risk was observed, and associations between APOE with elevated levels of low-density lipoprotein (LDL)-cholesterol and triglycerides, the SNPrs1501299 with the AIP, the AA/rs708272 and GG/rs1884051 genotypes, with high LDL levels and genotype AA/rs854560 with LDL-c and paraoxonase activity. The results indicate that blood and genetic biomarkers might be involved in metabolic alterations and thus increase the individual's risk for disease development. 
publishDate 2015
dc.date.none.fl_str_mv 2015-07-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artículo revisado por pares
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/751
10.15174/au.2015.751
url https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/751
identifier_str_mv 10.15174/au.2015.751
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/751/pdf_81
https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/751/html_74
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Universidad de Guanajuato
publisher.none.fl_str_mv Universidad de Guanajuato
dc.source.none.fl_str_mv Acta Universitaria; Vol. 25 (2015): (NE-1) Ciencias Médicas; 9-13
Acta Universitaria; Vol. 25 (2015): (NE-1) Ciencias Médicas; 9-13
2007-9621
0188-6266
reponame:Acta Universitaria
instname:UNIVERSIDAD DE GUANAJUATO
instacron:UGTO
instname_str UNIVERSIDAD DE GUANAJUATO
instacron_str UGTO
institution UGTO
reponame_str Acta Universitaria
collection Acta Universitaria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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