Isodicentric Y chromosomes and secondary microchromosomes.
We report here on two mosaic patients with both an idic(Yp) and a microchromosome. FISH with the DYZ3 alphoid repeat demonstrated that the isodicentrics effectively exhibited two alphoid clusters whereas the small markers had a Y-centromere. These data, along with 4 previous observations, indicate t...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2003 |
| País: | México |
| Institución: | Universidad de Guadalajara |
| Repositorio: | Repositorio UDG CUALTOS |
| OAI Identifier: | oai:repositorio.cualtos.udg.mx:123456789/417 |
| Acceso en línea: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/417 |
| Access Level: | acceso abierto |
| Palabra clave: | isodicentric Y-chromosomes microchromosomes functional dicentricity centromere excision |
| Sumario: | We report here on two mosaic patients with both an idic(Yp) and a microchromosome. FISH with the DYZ3 alphoid repeat demonstrated that the isodicentrics effectively exhibited two alphoid clusters whereas the small markers had a Y-centromere. These data, along with 4 previous observations, indicate that such microchromosomes effectively result from functional dicentricity of isodicentric Y-chromosomes and represent the excision of one centromere plus various amounts of adjacent chromatin. Other than a real infrequency of such a concurrence or a very low proportion of the cell line(s) containing the microchromosome, the paucity of observations points to a high rate of underdiagnosis as revealed by two idic(Y) instances in which the microchromosome was detected only in samples assessed by FISH. |
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