RENEB interlaboratory comparison for biological dosimetry based on dicentric chromosome analysis and cobalt-60 exposures higher than 2.5 Gy

In previous RENEB interlaboratory comparisons based on the manual scoring of dicentric chromosomes, a tendency for systematic overestimation for doses > 2.5 Gy was found. However, these exercises included only very few doses in the high dose range, and they were heterogeneous in terms of radiatio...

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Detalles Bibliográficos
Autores: Bucher, Martin|||0000-0002-7643-0192, Endesfelder, David|||0009-0008-8942-8017, Pojtinger, Stefan|||0000-0001-6397-4572, Baeyens, Ans|||0000-0002-2578-7917, Barquinero, Joan Francesc|||0000-0003-0084-5268, Beinke, Christina, Bobyk, Laure, Gregoire, Eric|||0000-0002-1859-3727, Hristova, Rositsa|||0000-0002-7455-3025, Martinez, Juan S., Meher, Prabodha Kumar|||0000-0002-2391-1160, Milanová, Marcela|||0000-0002-2339-6197, Monteiro Gil, Octávia|||0000-0002-0366-8124, Montoro, Alegria|||0000-0003-1662-1592, Moquet, Jayne|||0000-0003-0448-4607, Moreno Domene, Mercedes|||0009-0004-2676-6247, Prieto Rodríguez, María Jesús|||0009-0004-8292-2558, Pujol Canadell, Mònica|||0000-0002-7403-9683, Sun, Mingzhu|||0000-0003-2205-0503, Terzoudi, Georgia I.|||0000-0001-6213-5072, Tichy, Ales|||0000-0002-8262-5703, Triantopoulou, Sotiria|||0009-0007-1918-4558, Valente, Marco, Vral, Anne|||0000-0001-7879-6561, Wojcik, Andrzej|||0000-0002-3951-774X, Oestreicher, Ursula|||0009-0007-9024-0110
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:321022
Acceso en línea:https://ddd.uab.cat/record/321022
https://dx.doi.org/urn:doi:10.1038/s41598-025-89966-2
Access Level:acceso abierto
Palabra clave:Ionising radiation
Biological dosimetry
Dicentric chromosome
Interlaboratory comparison
Network
Radiation accident
Cytogenetics
Chromosomes
Diagnostic markers
Descripción
Sumario:In previous RENEB interlaboratory comparisons based on the manual scoring of dicentric chromosomes, a tendency for systematic overestimation for doses > 2.5 Gy was found. However, these exercises included only very few doses in the high dose range, and they were heterogeneous in terms of radiation quality and evaluation mode, and comparable only to a limited extent. Here, this presumed deviation was explored by investigating three doses > 2.5 Gy. Blood samples were irradiated (2.56, 3.41 and 4.54 Gy) using a 60Co source and sent to 14 member laboratories of the RENEB network, which performed the dicentric chromosome assay (manual and/or semi-automatic scoring) and reported dose estimates. Most participants provided estimates that agreed very well with the physical reference doses and all provided dose estimates were in the correct clinical category (> 2 Gy). The previously observed tendency for a systematic bias across all laboratories was not confirmed. However, tendencies for systematic underestimation were detected for dose estimations for reference doses given in terms of absorbed dose to blood and for some participants, a laboratory-specific trend of systematic under- or overestimation was observed. The importance of regularly performed quality checks for a broad dose range became obvious to avoid misinterpretation of results.

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