Effect of the structure and concentration of cyclodextrins in the quenching process of naproxen
[EN]The effect of the formation of the naproxen:cyclodextrin inclusion complex on the quenching of the drug by iodide has been studied. The results show that -cyclodextrin ( -CD), -cyclodextrin ( -CD), and hydroxypropyl- -cyclodextrin (HP- -CD) provide good protection for the drug against iodide que...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2006 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:dnet:gredos______::7d6fbdc242282a937fc98ec1c1b0ddd1 |
| Acceso en línea: | http://hdl.handle.net/10366/171024 |
| Access Level: | acceso abierto |
| Palabra clave: | Quenching Naproxen Hydroxypropyl alpha-Cyclodextrins beta-Cyclodextrins naproxeno alfa-ciclodextrinas beta-ciclodextrinas |
| Sumario: | [EN]The effect of the formation of the naproxen:cyclodextrin inclusion complex on the quenching of the drug by iodide has been studied. The results show that -cyclodextrin ( -CD), -cyclodextrin ( -CD), and hydroxypropyl- -cyclodextrin (HP- -CD) provide good protection for the drug against iodide quenching. The trend of protection is -CD > HP- -CD≈ -CD>H2O, in contrast to the binding constant values and the structure of these complexes. The effect of these cyclodextrins on the quenching process is discussed on the basis of the parameters obtained by fitting the experimental data to the modified Stern–Volmer, and finite-sink approximation models. |
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