Obstetric complications and clinical presentation in first episode of psychosis

Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disor...

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Autores: Verdolini, Norma, Mezquida Mateos, Gisela, Valli, Isabel, García Rizo, Clemente, Cuesta, Manuel J., Vieta i Pascual, Eduard, 1963-, Bioque Alcázar, Miquel, Lobo, Antonio, González-Pinto, Ana, Pina Camacho, Laura, Corripio, Iluminada, Garriga, Marina, Baeza, Inmaculada, 1970-, Martínez Sadurní, Laura, Bitanihirwe, Byron, Cannon, Mary, Bernardo Arroyo, Miquel, PEPs GROUP.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/219386
Acceso en línea:https://hdl.handle.net/2445/219386
Access Level:acceso abierto
Palabra clave:Psicosi
Complicacions en el part
Psicopatologia
Obstetrícia
Psychoses
Labor complications (Obstetrics)
Pathological psychology
Obstetrics
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spelling Obstetric complications and clinical presentation in first episode of psychosisVerdolini, NormaMezquida Mateos, GiselaValli, IsabelGarcía Rizo, ClementeCuesta, Manuel J.Vieta i Pascual, Eduard, 1963-Bioque Alcázar, MiquelLobo, AntonioGonzález-Pinto, AnaPina Camacho, LauraCorripio, IluminadaGarriga, MarinaBaeza, Inmaculada, 1970-Martínez Sadurní, LauraBitanihirwe, ByronCannon, MaryBernardo Arroyo, MiquelPEPs GROUP.PsicosiComplicacions en el partPsicopatologiaObstetríciaPsychosesLabor complications (Obstetrics)Pathological psychologyObstetricsObjective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods: Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis–Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results: Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions: Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.Cambridge University Press (CUP)2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/219386Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1017/neu.2023.9Acta Neuropsychiatrica, 2023, vol. 35, num.3, p. 156-164https://doi.org/10.1017/neu.2023.9cc-by (c) Verdolini, Norma et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2193862026-05-27T06:46:51Z
dc.title.none.fl_str_mv Obstetric complications and clinical presentation in first episode of psychosis
title Obstetric complications and clinical presentation in first episode of psychosis
spellingShingle Obstetric complications and clinical presentation in first episode of psychosis
Verdolini, Norma
Psicosi
Complicacions en el part
Psicopatologia
Obstetrícia
Psychoses
Labor complications (Obstetrics)
Pathological psychology
Obstetrics
title_short Obstetric complications and clinical presentation in first episode of psychosis
title_full Obstetric complications and clinical presentation in first episode of psychosis
title_fullStr Obstetric complications and clinical presentation in first episode of psychosis
title_full_unstemmed Obstetric complications and clinical presentation in first episode of psychosis
title_sort Obstetric complications and clinical presentation in first episode of psychosis
dc.creator.none.fl_str_mv Verdolini, Norma
Mezquida Mateos, Gisela
Valli, Isabel
García Rizo, Clemente
Cuesta, Manuel J.
Vieta i Pascual, Eduard, 1963-
Bioque Alcázar, Miquel
Lobo, Antonio
González-Pinto, Ana
Pina Camacho, Laura
Corripio, Iluminada
Garriga, Marina
Baeza, Inmaculada, 1970-
Martínez Sadurní, Laura
Bitanihirwe, Byron
Cannon, Mary
Bernardo Arroyo, Miquel
PEPs GROUP.
author Verdolini, Norma
author_facet Verdolini, Norma
Mezquida Mateos, Gisela
Valli, Isabel
García Rizo, Clemente
Cuesta, Manuel J.
Vieta i Pascual, Eduard, 1963-
Bioque Alcázar, Miquel
Lobo, Antonio
González-Pinto, Ana
Pina Camacho, Laura
Corripio, Iluminada
Garriga, Marina
Baeza, Inmaculada, 1970-
Martínez Sadurní, Laura
Bitanihirwe, Byron
Cannon, Mary
Bernardo Arroyo, Miquel
PEPs GROUP.
author_role author
author2 Mezquida Mateos, Gisela
Valli, Isabel
García Rizo, Clemente
Cuesta, Manuel J.
Vieta i Pascual, Eduard, 1963-
Bioque Alcázar, Miquel
Lobo, Antonio
González-Pinto, Ana
Pina Camacho, Laura
Corripio, Iluminada
Garriga, Marina
Baeza, Inmaculada, 1970-
Martínez Sadurní, Laura
Bitanihirwe, Byron
Cannon, Mary
Bernardo Arroyo, Miquel
PEPs GROUP.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psicosi
Complicacions en el part
Psicopatologia
Obstetrícia
Psychoses
Labor complications (Obstetrics)
Pathological psychology
Obstetrics
topic Psicosi
Complicacions en el part
Psicopatologia
Obstetrícia
Psychoses
Labor complications (Obstetrics)
Pathological psychology
Obstetrics
description Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods: Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis–Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results: Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions: Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219386
url https://hdl.handle.net/2445/219386
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1017/neu.2023.9
Acta Neuropsychiatrica, 2023, vol. 35, num.3, p. 156-164
https://doi.org/10.1017/neu.2023.9
dc.rights.none.fl_str_mv cc-by (c) Verdolini, Norma et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Verdolini, Norma et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press (CUP)
publisher.none.fl_str_mv Cambridge University Press (CUP)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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