Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis

Schizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to...

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Bibliographic Details
Authors: Forte, Maria Florencia, Oliva, Vincenzo, De Prisco, Michele, Garriga, Marina, Bitanihirwe, Byron, Alameda, Luis, Gonzalez Segura, Àlex, Vieta i Pascual, Eduard, 1963-, Baeza, Inmaculada, 1970-, Parellada Rodón, Eduard, Penadés Rubio, Rafael, Ramos Quiroga, Josep Antoni, Amoretti Guadall, Silvia, Mezquida Mateos, Gisela, García Rizo, Clemente
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219486
Online Access:https://hdl.handle.net/2445/219486
Access Level:Open access
Keyword:Complicacions en el part
Psicopatologia infantil
Metaanàlisi
Esquizofrènia
Psicosi
Labor complications (Obstetrics)
Child psychopathology
Meta-analysis
Schizophrenia
Psychoses
Description
Summary:Schizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to comprehensively evaluate differences in psychopathology between individuals with and without exposure to OCs in relation to SZ and related disorders. We systematically searched PubMed, PsycINFO, and SCOPUS to identify eligible studies. A total of 4091 records were retrieved through systematic and citation searches. 14 studies were included in the review, and 12 met the criteria for meta-analysis, involving 2992 patients. The analysis revealed that SZ patients who had been exposed to OCs exhibited significantly higher levels of positive symptoms (SMD=0.10, 95 %CI=0.01,0.20; p=0.03), general psychopathology (SMD=0.37, 95 %CI=0.22,0.52; p<0.001), total clinical symptomatology (SMD=0.44, 95 %CI=0.24,0.64; p<0.001) and depressive symptoms (SMD=0.47, 95 %CI=0.09,0.84; p=0.01). No significant differences were found in negative symptomatology and functioning. Our results suggest that OCs are not only associated with an increased risk of developing psychosis but with more severe symptomatology.

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