miR-27b-3p modulates liver sinusoidal endothelium dedifferentiation in chronic liver disease
[Background] During chronic liver diseases, LSECs undergo a dedifferentiation process contributing to the development of hepatic microvascular dysfunction. Although microRNAs (miRNAs) have been associated with chronic liver disease, their role as modulators of liver endothelial phenotype is mostly u...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/391238 |
| Acceso en línea: | http://hdl.handle.net/10261/391238 https://api.elsevier.com/content/abstract/scopus_id/105005186329 |
| Access Level: | acceso abierto |
| Palabra clave: | LSEC Cirrhosis Endothelial-to-mesenchymal transition Hepatic microcirculation Quantum dots |
| Sumario: | [Background] During chronic liver diseases, LSECs undergo a dedifferentiation process contributing to the development of hepatic microvascular dysfunction. Although microRNAs (miRNAs) have been associated with chronic liver disease, their role as modulators of liver endothelial phenotype is mostly unknown. Therefore, the aim of this study was to analyze miRNAs as regulators of hepatic sinusoidal endothelial dysfunction in chronic liver disease to suggest novel and translatable therapeutic options for cirrhosis. |
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