Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension

Portal hypertension (PH) is a frequent and severe clinical syndrome associated with chronic liver disease. Considering the mechanobiological effects of hydrostatic pressure and shear stress on endothelial cells, we hypothesised that PH might influence the phenotype of liver sinusoidal endothelial ce...

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Detalles Bibliográficos
Autores: Ortega-Ribera, Martí, Gibert-Ramos, Albert, Abad-Jordà, Laia, Magaz, Marta, Téllez, Luis, Paule, Lorena, Castillo, Elisa, Pastó, Raül, de Souza Basso, Bruno, Olivas, Pol, Orts, Lara, Lozano, Juan José, Villa, Rosa, Bosch, Jaime, Albillos, Agustín, García-Pagán, Joan Carles, Gracia-Sancho, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/350107
Acceso en línea:http://hdl.handle.net/10261/350107
https://api.elsevier.com/content/abstract/scopus_id/85153400368
Access Level:acceso abierto
Palabra clave:Endothelial dysfunction
HCV
HVPG
Hepatic haemodynamic
LSEC
Liver cirrhosis
Liver sinusoidal endothelial cells
Mechanobiology
Mechanotransduction
NASH
Descripción
Sumario:Portal hypertension (PH) is a frequent and severe clinical syndrome associated with chronic liver disease. Considering the mechanobiological effects of hydrostatic pressure and shear stress on endothelial cells, we hypothesised that PH might influence the phenotype of liver sinusoidal endothelial cells (LSECs) during disease progression. The aim of this study was to investigate the effects of increased hydrodynamic pressure on LSECs and to identify endothelial-derived biomarkers of PH.

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