Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal...
| Autores: | , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2001 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositório: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/16667 |
| Acesso em linha: | http://hdl.handle.net/10230/16667 http://dx.doi.org/10.1523/jneurosci.21-23-09499.2001 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cannabinoides -- Efectes fisiològics Cannabinoides -- Receptors Cannabinoid Opioid Mice Mutation Withdrawal Addiction Place aversion |
| Resumo: | The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana. |
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