The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Espanol de Tratamientos en Hematolo...

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Detalhes bibliográficos
Autores: Ribera, J, Granada, I, Morgades, M, Vives, S, Genesca, E, Gonzalez, C, Nomdedeu, J, Escoda, L, Montesinos, P, Mercadal, S, Coll, R, Gonzalez-Campos, J, Abella, E, Barba, P, Bermudez, A, Gil, C, Tormo, M, Pedreno, M, Martinez-Carballeira, D, Hernandez-Rivas, JM, Orfao, A, Martinez-Lopez, J, Esteve, J, Bravo, P, Garcia-Guinon, A, Deben, G, Moraleda, JM, Queizan, JA, Ortin, X, Moreno, MJ, Feliu, E, Sole, F, Ribera, JM
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p2575
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2575
Access Level:acceso abierto
Palavra-chave:acute lymphoblastic leukaemia
adults
hypodiploidy
prognosis
age
Descrição
Resumo:The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Espanol de Tratamientos en Hematologia (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged <= 35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.

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