Prognostic heterogeneity of adult B-cell precursor acute lymphoblastic leukaemia patients with t(1

The prognosis of t(1;19)(q23;p13)/transcription factor 3-pre-B-cell leukaemia homeobox 1 (TCF3-PBX1) in adolescent and adult patients with acute lymphoblastic leukaemia (ALL) treated with measurable residual disease (MRD)-oriented trials remains controversial. In the present study, we analysed the o...

ver descrição completa

Detalhes bibliográficos
Autores: Ribera, J. (Jordi)|||/items/339b9b7d-f922-4e13-ad8e-516f2474db3e, Granada, I. (Isabel)|||/items/79e98521-387f-4b95-ad32-faf1c95b8e1e, Morgades, M. (Mireia)|||/items/76453fda-c1b2-4d0c-a98f-9fe56125b19a, González-Ramírez, T. (Teresa)|||/items/c6ba2859-f97f-4fa3-9c93-d6ec7e853c05, Ciudad, J. (Juana)|||/items/310fa310-62be-442c-a32a-3bd60c0078d5, Such, E. (Esperanza)|||/items/6be20352-34f2-41aa-8e65-c71dd9e3cb01, Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086, Mercadal, S. (Santiago)|||/items/97af2845-3ae0-4ea3-9422-9c4e83524c55, Coll, R. (Rosa)|||/items/98e89237-be18-4940-9217-74df9876c531, González-Campos, J. (José)|||/items/b24d4312-5097-4ff3-af38-6c4f8009cad5, Tormo, M. (Mar)|||/items/41f3a12f-e4b6-4644-ac45-c544d3f0f458, García-Cadenas, I. (Irene)|||/items/e9d945d9-cf97-4301-a7fe-8ae6d6cae6fd, Gil, C. (Cristina)|||/items/22dc665c-a4b8-4acd-833f-e8070a5a0d44, Cervera, M. (Marta)|||/items/b9b016ae-54b0-4e84-bab1-f266c28c47e6, Barba, P. (Pere)|||/items/7d7d6696-b40c-4396-9593-da581d39062c, Costa, D. (Dolors)|||/items/0f69ed63-f221-4ad2-b89a-cef26df3eaf0, Ayala, R. (Rosa)|||/items/7c3d4d6c-7864-4b3d-acd4-de118b9efb49, Bermudez, A. (Arancha)|||/items/279c48ea-3bdb-4303-926a-03fa2f9b2574, Orfao, A. (Alberto)|||/items/7ed3636b-0c92-4f3f-aed7-a9894c59af83, Ribera, J.M. (José María)|||/items/de9bc636-9d99-47c6-b369-bb3b37967e8e
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/123588
Acesso em linha:https://hdl.handle.net/10171/123588
Access Level:acceso abierto
Palavra-chave:Acute lymphoblastic leukaemia
Adults
Cytogenetic alterations
Prognosis
T(1-19)(q23-p13)/TCF3-PBX1
Descrição
Resumo:The prognosis of t(1;19)(q23;p13)/transcription factor 3-pre-B-cell leukaemia homeobox 1 (TCF3-PBX1) in adolescent and adult patients with acute lymphoblastic leukaemia (ALL) treated with measurable residual disease (MRD)-oriented trials remains controversial. In the present study, we analysed the outcome of adolescent and adult patients with t(1;19)(q23;p13) enrolled in paediatric-inspired trials. The patients with TCF3-PBX1 showed similar MRD clearance and did not have different survival compared with other B-cell precursor ALL patients. However, patients with TCF3-PBX1 had a significantly higher cumulative incidence of relapse, especially among patients aged ≥35 years carrying additional cytogenetic alterations. These patients might benefit from additional/intensified therapy (e.g. immunotherapy in first complete remission with or without subsequent haematopoietic stem cell transplantation).

Registos relacionados