Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which re...

Descripción completa

Detalles Bibliográficos
Autores: Burguera, Demián, Márquez, Yamile, Racioppi, Claudia, Permanyer, Jon, Torres Méndez, Antonio, Esposito, Rosaria, Albuixech Crespo, Beatriz, Fanlo, Lucía, D'Agostino, Ylenia, Gohr, André, Navas Pérez, Enrique, Riesgo, Ana, Cuomo, Claudia, Benvenuto, Giovanna, Christiaen, Lionel A., Martí, Elisa, D'Aniello, Salvatore, Spagnuolo, Antonietta, Ristoratore, Filomena, Arnone, Maria Ina, García Fernàndez, Jordi, Irimia Martínez, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/34949
Acceso en línea:http://hdl.handle.net/10230/34949
http://dx.doi.org/10.1038/s41467-017-01961-y
Access Level:acceso abierto
Palabra clave:Evolutionary developmental biology
Transcriptomics
Esrp genes
Descripción
Sumario:Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates.

Similares en LA Referencia