Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which re...

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Detalles Bibliográficos
Autores: Burguera, Demian, Marquez, Yamile, Racioppi, Claudia, Permanyer, Jon, Torres-Méndez, Antonio, Esposito, Rosaria, Albuixech-Crespo, Beatriz, Fanlo, Lucía, D’Agostino, Ylenia, Gohr, Andre, Navas-Perez, Enrique, Riesgo Gil, Ana, Cuomo, Claudia, Benvenuto, Giovanna, Christiaen, Lionel A., Martí, Elisa, D’Aniello, Salvatore, Spagnuolo, Antonietta, Ristoratore, Filomena, Arnone, Maria Ina, Garcia-Fernàndez, Jordi, Irimia, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/174600
Acceso en línea:http://hdl.handle.net/10261/174600
Access Level:acceso abierto
Descripción
Sumario:Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates.

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