Impact of Synonymous Genome Recoding on the HIV Life Cycle

Synonymous mutations within protein coding regions introduce changes in DNA or messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus genomes has facilitated the identification of previously unknown virus biological features. Moreover, large-scale synonymous recoding...

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Autores: Jordan de Paiz, Ana|||0000-0002-3495-7201, Franco Cirera, Sandra|||0000-0003-4126-2202, Martínez, Miguel Angel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255398
Acceso en línea:https://ddd.uab.cat/record/255398
https://dx.doi.org/urn:doi:10.3389/fmicb.2021.606087
Access Level:acceso abierto
Palabra clave:HIV-1
Synonymous
Mutations
Virus
Phenotype
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spelling Impact of Synonymous Genome Recoding on the HIV Life CycleJordan de Paiz, Ana|||0000-0002-3495-7201Franco Cirera, Sandra|||0000-0003-4126-2202Martínez, Miguel AngelHIV-1SynonymousMutationsVirusPhenotypeSynonymous mutations within protein coding regions introduce changes in DNA or messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus genomes has facilitated the identification of previously unknown virus biological features. Moreover, large-scale synonymous recoding of the genome of human immunodeficiency virus type 1 (HIV-1) has elucidated new antiviral mechanisms within the innate immune response, and has improved our knowledge of new functional virus genome structures, the relevance of codon usage for the temporal regulation of viral gene expression, and HIV-1 mutational robustness and adaptability. Continuous improvements in our understanding of the impacts of synonymous substitutions on virus phenotype - coupled with the decreased cost of chemically synthesizing DNA and improved methods for assembling DNA fragments - have enhanced our ability to identify potential HIV-1 and host factors and other aspects involved in the infection process. In this review, we address how silent mutagenesis impacts HIV-1 phenotype and replication capacity. We also discuss the general potential of synonymous recoding of the HIV-1 genome to elucidate unknown aspects of the virus life cycle, and to identify new therapeutic targets.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255398https://dx.doi.org/urn:doi:10.3389/fmicb.2021.606087reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-103955RB-I00Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BES-2014-069931open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2553982026-06-06T12:50:31Z
dc.title.none.fl_str_mv Impact of Synonymous Genome Recoding on the HIV Life Cycle
title Impact of Synonymous Genome Recoding on the HIV Life Cycle
spellingShingle Impact of Synonymous Genome Recoding on the HIV Life Cycle
Jordan de Paiz, Ana|||0000-0002-3495-7201
HIV-1
Synonymous
Mutations
Virus
Phenotype
title_short Impact of Synonymous Genome Recoding on the HIV Life Cycle
title_full Impact of Synonymous Genome Recoding on the HIV Life Cycle
title_fullStr Impact of Synonymous Genome Recoding on the HIV Life Cycle
title_full_unstemmed Impact of Synonymous Genome Recoding on the HIV Life Cycle
title_sort Impact of Synonymous Genome Recoding on the HIV Life Cycle
dc.creator.none.fl_str_mv Jordan de Paiz, Ana|||0000-0002-3495-7201
Franco Cirera, Sandra|||0000-0003-4126-2202
Martínez, Miguel Angel
author Jordan de Paiz, Ana|||0000-0002-3495-7201
author_facet Jordan de Paiz, Ana|||0000-0002-3495-7201
Franco Cirera, Sandra|||0000-0003-4126-2202
Martínez, Miguel Angel
author_role author
author2 Franco Cirera, Sandra|||0000-0003-4126-2202
Martínez, Miguel Angel
author2_role author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv HIV-1
Synonymous
Mutations
Virus
Phenotype
topic HIV-1
Synonymous
Mutations
Virus
Phenotype
description Synonymous mutations within protein coding regions introduce changes in DNA or messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus genomes has facilitated the identification of previously unknown virus biological features. Moreover, large-scale synonymous recoding of the genome of human immunodeficiency virus type 1 (HIV-1) has elucidated new antiviral mechanisms within the innate immune response, and has improved our knowledge of new functional virus genome structures, the relevance of codon usage for the temporal regulation of viral gene expression, and HIV-1 mutational robustness and adaptability. Continuous improvements in our understanding of the impacts of synonymous substitutions on virus phenotype - coupled with the decreased cost of chemically synthesizing DNA and improved methods for assembling DNA fragments - have enhanced our ability to identify potential HIV-1 and host factors and other aspects involved in the infection process. In this review, we address how silent mutagenesis impacts HIV-1 phenotype and replication capacity. We also discuss the general potential of synonymous recoding of the HIV-1 genome to elucidate unknown aspects of the virus life cycle, and to identify new therapeutic targets.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/255398
https://dx.doi.org/urn:doi:10.3389/fmicb.2021.606087
url https://ddd.uab.cat/record/255398
https://dx.doi.org/urn:doi:10.3389/fmicb.2021.606087
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-103955RB-I00
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BES-2014-069931
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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