Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats

Background: The utilization of methylphenidate (MPH) is experiencing a notable surge within the adult population. This growth can be attributed to two key factors: its recreational and cognitive enhancement purposes, as well as the rising prevalence of ADHD diagnoses within this population. This stu...

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Autores: Montiel Herrera, Fátima, Batanero-Geraldo, Adela, López García, Juan Carlos, Vargas Romero, Juan Pedro, Quintero Sánchez, Esperanza, Díaz Argandoña, Estrella
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/156817
Acceso en línea:https://hdl.handle.net/11441/156817
https://doi.org/10.1016/j.physbeh.2024.114526
Access Level:acceso abierto
Palabra clave:methylphenidate
ADHD
sex differences
chronic administration
sensorimotor gating
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spelling Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar ratsMontiel Herrera, FátimaBatanero-Geraldo, AdelaLópez García, Juan CarlosVargas Romero, Juan PedroQuintero Sánchez, EsperanzaDíaz Argandoña, EstrellamethylphenidateADHDsex differenceschronic administrationsensorimotor gatingBackground: The utilization of methylphenidate (MPH) is experiencing a notable surge within the adult population. This growth can be attributed to two key factors: its recreational and cognitive enhancement purposes, as well as the rising prevalence of ADHD diagnoses within this population. This study examined acute and chronic oral MPH effects on attention in male and female Wistar rats. To this end, we used a prepulse inhibition (PPI) task, which is widely used to assess psychoactive drug effects in both humans and rodents. This task allowed us to evaluate changes in attention by analyzing sensorimotor gating associated with stimulus selection process. Methods: Animals were administered a clinically relevant dose of MPH (5 mg/kg) daily for seven days. The estrous cycle phases of the female rats were measured during behavioral sessions. The PPI task was conducted 20 min after drug administration on day 1 (acute), day 7 (chronic), and 48 h post-treatment. Results: Results indicated that both acute and chronic MPH treatment impaired PPI expression in male rats, but not in female rats, regardless of their estrous cycle phase. Furthermore, a differential effect of chronic MPH treatment on the PPI task was found in male rats. Specifically, on the seventh treatment day, the PPI effect was observed when animals undertook the PPI task for the first time but was impaired in those animals in which the initial PPI session occurred under the acute influence of the drug (day 1). Conclusions: These findings suggest that the impact of MPH on sensorimotor gating responses may vary based on sex and task experience, possibly leading to state-dependent effects in healthy individuals.Ministerio de Ciencia, Innovación y Universidades PID2019-110739GB-I00Unión Europea PID2019-110739GB-I00ElsevierPsicología Experimental2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11441/156817https://doi.org/10.1016/j.physbeh.2024.114526reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésPhysiology & Behavior, 278, 114526.PID2019-110739GB-I00https://doi.org/10.1016/j.physbeh.2024.114526info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1568172026-06-17T12:51:07Z
dc.title.none.fl_str_mv Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
title Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
spellingShingle Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
Montiel Herrera, Fátima
methylphenidate
ADHD
sex differences
chronic administration
sensorimotor gating
title_short Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
title_full Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
title_fullStr Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
title_full_unstemmed Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
title_sort Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats
dc.creator.none.fl_str_mv Montiel Herrera, Fátima
Batanero-Geraldo, Adela
López García, Juan Carlos
Vargas Romero, Juan Pedro
Quintero Sánchez, Esperanza
Díaz Argandoña, Estrella
author Montiel Herrera, Fátima
author_facet Montiel Herrera, Fátima
Batanero-Geraldo, Adela
López García, Juan Carlos
Vargas Romero, Juan Pedro
Quintero Sánchez, Esperanza
Díaz Argandoña, Estrella
author_role author
author2 Batanero-Geraldo, Adela
López García, Juan Carlos
Vargas Romero, Juan Pedro
Quintero Sánchez, Esperanza
Díaz Argandoña, Estrella
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Psicología Experimental
dc.subject.none.fl_str_mv methylphenidate
ADHD
sex differences
chronic administration
sensorimotor gating
topic methylphenidate
ADHD
sex differences
chronic administration
sensorimotor gating
description Background: The utilization of methylphenidate (MPH) is experiencing a notable surge within the adult population. This growth can be attributed to two key factors: its recreational and cognitive enhancement purposes, as well as the rising prevalence of ADHD diagnoses within this population. This study examined acute and chronic oral MPH effects on attention in male and female Wistar rats. To this end, we used a prepulse inhibition (PPI) task, which is widely used to assess psychoactive drug effects in both humans and rodents. This task allowed us to evaluate changes in attention by analyzing sensorimotor gating associated with stimulus selection process. Methods: Animals were administered a clinically relevant dose of MPH (5 mg/kg) daily for seven days. The estrous cycle phases of the female rats were measured during behavioral sessions. The PPI task was conducted 20 min after drug administration on day 1 (acute), day 7 (chronic), and 48 h post-treatment. Results: Results indicated that both acute and chronic MPH treatment impaired PPI expression in male rats, but not in female rats, regardless of their estrous cycle phase. Furthermore, a differential effect of chronic MPH treatment on the PPI task was found in male rats. Specifically, on the seventh treatment day, the PPI effect was observed when animals undertook the PPI task for the first time but was impaired in those animals in which the initial PPI session occurred under the acute influence of the drug (day 1). Conclusions: These findings suggest that the impact of MPH on sensorimotor gating responses may vary based on sex and task experience, possibly leading to state-dependent effects in healthy individuals.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/156817
https://doi.org/10.1016/j.physbeh.2024.114526
url https://hdl.handle.net/11441/156817
https://doi.org/10.1016/j.physbeh.2024.114526
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Physiology & Behavior, 278, 114526.
PID2019-110739GB-I00
https://doi.org/10.1016/j.physbeh.2024.114526
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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