Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)

Di Carlo, Veronica; Stiller, Charles A.; Eisemann, Nora; Bordoni, Andrea; Matz, Melissa; Curado, Maria P.; Daubisse-Marliac, Laetitia; Valkov, Mikhail; Bulliard, Jean-Luc; Morrison, David; Johnson, Christopher J.; Girardi, Fabio; Marcos-Gragera, Rafael; Šekerija, Mario; Larønningen, Siri; Sirri, Eunice; Coleman, Michel P.; Allemani, Claudia; CONCORD Working Group

Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)

Background CONCORD-3 highlighted wide disparities in population-based 5-year net survival for cutaneous melanoma during 2000–2014. Clinical evidence suggests marked international differences in the proportion of lethal acral and nodular subtypes of cutaneous melanoma. Objectives We aimed to assess w...

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Detalles Bibliográficos
Autores:	Di Carlo, Veronica, Stiller, Charles A., Eisemann, Nora, Bordoni, Andrea, Matz, Melissa, Curado, Maria P., Daubisse-Marliac, Laetitia, Valkov, Mikhail, Bulliard, Jean-Luc, Morrison, David, Johnson, Christopher J., Girardi, Fabio, Marcos-Gragera, Rafael, Šekerija, Mario, Larønningen, Siri, Sirri, Eunice, Coleman, Michel P., Allemani, Claudia, CONCORD Working Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:10256/21746
Acceso en línea:	http://hdl.handle.net/10256/21746
Access Level:	acceso abierto
Palabra clave:	Supervivència Survival Melanoma Pell -- Càncer -- Estadístiques Skin -- Cancer -- Statistics

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spelling	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)Di Carlo, VeronicaStiller, Charles A.Eisemann, NoraBordoni, AndreaMatz, MelissaCurado, Maria P.Daubisse-Marliac, LaetitiaValkov, MikhailBulliard, Jean-LucMorrison, DavidJohnson, Christopher J.Girardi, FabioMarcos-Gragera, RafaelŠekerija, MarioLarønningen, SiriSirri, EuniceColeman, Michel P.Allemani, ClaudiaCONCORD Working GroupSupervivènciaSurvivalMelanomaPell -- Càncer -- EstadístiquesSkin -- Cancer -- StatisticsBackground CONCORD-3 highlighted wide disparities in population-based 5-year net survival for cutaneous melanoma during 2000–2014. Clinical evidence suggests marked international differences in the proportion of lethal acral and nodular subtypes of cutaneous melanoma. Objectives We aimed to assess whether the differences in morphology may explain global variation in survival. Methods Patients with melanoma were grouped into the following seven morphological categories: malignant melanoma, not otherwise specified (International Classification of Diseases for Oncology, third revision morphology code 8720), superficial spreading melanoma (8743), lentigo maligna melanoma (8742), nodular melanoma (8721), acral lentiginous melanoma (8744), desmoplastic melanoma (8745) and other morphologies (8722–8723, 8726–8727, 8730, 8740–8741, 8746, 8761, 8770–8774, 8780). We estimated net survival using the nonparametric Pohar Perme estimator, correcting for background mortality by single year of age, sex and calendar year in each country or region. All-ages survival estimates were standardized using the International Cancer Survival Standard weights. We fitted a flexible parametric model to estimate the effect of morphology on the hazard of death. Results Worldwide, the proportion of nodular melanoma ranged between 7% and 13%. Acral lentiginous melanoma accounted for less than 2% of all registrations but was more common in Asia (6%) and Central and South America (7%). Overall, 36% of tumours were classified as superficial spreading melanoma. During 2010–2014, age-standardized 5-year net survival for superficial spreading melanoma was 95% or higher in Oceania, North America and most European countries, but was only 71% in Taiwan. Survival for acral lentiginous melanoma ranged between 66% and 95%. Nodular melanoma had the poorest prognosis in all countries. The multivariable analysis of data from registries with complete information on stage and morphology found that sex, age and stage at diagnosis only partially explain the higher risk of death for nodular and acral lentiginous subtypes. Conclusions This study provides the broadest picture of distribution and population-based survival trends for the main morphological subtypes of cutaneous melanoma in 59 countries. The poorer prognosis for nodular and acral lentiginous melanomas, more frequent in Asia and Latin America, suggests the need for health policies aimed at specific populations to improve awareness, early diagnosis and access to treatmentWiley2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/21746http://hdl.handle.net/10256/21746British Journal of Dermatology, 2022, vol. 187, núm. 3, p. 364-380Articles publicats (D-I)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1111/bjd.21274info:eu-repo/semantics/altIdentifier/issn/0007-0963info:eu-repo/semantics/altIdentifier/eissn/1365-2133Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/217462026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)
title	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)
spellingShingle	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3) Di Carlo, Veronica Supervivència Survival Melanoma Pell -- Càncer -- Estadístiques Skin -- Cancer -- Statistics
title_short	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)
title_full	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)
title_fullStr	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)
title_full_unstemmed	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)
title_sort	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)
dc.creator.none.fl_str_mv	Di Carlo, Veronica Stiller, Charles A. Eisemann, Nora Bordoni, Andrea Matz, Melissa Curado, Maria P. Daubisse-Marliac, Laetitia Valkov, Mikhail Bulliard, Jean-Luc Morrison, David Johnson, Christopher J. Girardi, Fabio Marcos-Gragera, Rafael Šekerija, Mario Larønningen, Siri Sirri, Eunice Coleman, Michel P. Allemani, Claudia CONCORD Working Group
author	Di Carlo, Veronica
author_facet	Di Carlo, Veronica Stiller, Charles A. Eisemann, Nora Bordoni, Andrea Matz, Melissa Curado, Maria P. Daubisse-Marliac, Laetitia Valkov, Mikhail Bulliard, Jean-Luc Morrison, David Johnson, Christopher J. Girardi, Fabio Marcos-Gragera, Rafael Šekerija, Mario Larønningen, Siri Sirri, Eunice Coleman, Michel P. Allemani, Claudia CONCORD Working Group
author_role	author
author2	Stiller, Charles A. Eisemann, Nora Bordoni, Andrea Matz, Melissa Curado, Maria P. Daubisse-Marliac, Laetitia Valkov, Mikhail Bulliard, Jean-Luc Morrison, David Johnson, Christopher J. Girardi, Fabio Marcos-Gragera, Rafael Šekerija, Mario Larønningen, Siri Sirri, Eunice Coleman, Michel P. Allemani, Claudia CONCORD Working Group
author2_role	author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Supervivència Survival Melanoma Pell -- Càncer -- Estadístiques Skin -- Cancer -- Statistics
topic	Supervivència Survival Melanoma Pell -- Càncer -- Estadístiques Skin -- Cancer -- Statistics
description	Background CONCORD-3 highlighted wide disparities in population-based 5-year net survival for cutaneous melanoma during 2000–2014. Clinical evidence suggests marked international differences in the proportion of lethal acral and nodular subtypes of cutaneous melanoma. Objectives We aimed to assess whether the differences in morphology may explain global variation in survival. Methods Patients with melanoma were grouped into the following seven morphological categories: malignant melanoma, not otherwise specified (International Classification of Diseases for Oncology, third revision morphology code 8720), superficial spreading melanoma (8743), lentigo maligna melanoma (8742), nodular melanoma (8721), acral lentiginous melanoma (8744), desmoplastic melanoma (8745) and other morphologies (8722–8723, 8726–8727, 8730, 8740–8741, 8746, 8761, 8770–8774, 8780). We estimated net survival using the nonparametric Pohar Perme estimator, correcting for background mortality by single year of age, sex and calendar year in each country or region. All-ages survival estimates were standardized using the International Cancer Survival Standard weights. We fitted a flexible parametric model to estimate the effect of morphology on the hazard of death. Results Worldwide, the proportion of nodular melanoma ranged between 7% and 13%. Acral lentiginous melanoma accounted for less than 2% of all registrations but was more common in Asia (6%) and Central and South America (7%). Overall, 36% of tumours were classified as superficial spreading melanoma. During 2010–2014, age-standardized 5-year net survival for superficial spreading melanoma was 95% or higher in Oceania, North America and most European countries, but was only 71% in Taiwan. Survival for acral lentiginous melanoma ranged between 66% and 95%. Nodular melanoma had the poorest prognosis in all countries. The multivariable analysis of data from registries with complete information on stage and morphology found that sex, age and stage at diagnosis only partially explain the higher risk of death for nodular and acral lentiginous subtypes. Conclusions This study provides the broadest picture of distribution and population-based survival trends for the main morphological subtypes of cutaneous melanoma in 59 countries. The poorer prognosis for nodular and acral lentiginous melanomas, more frequent in Asia and Latin America, suggests the need for health policies aimed at specific populations to improve awareness, early diagnosis and access to treatment
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10256/21746 http://hdl.handle.net/10256/21746
url	http://hdl.handle.net/10256/21746
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.1111/bjd.21274 info:eu-repo/semantics/altIdentifier/issn/0007-0963 info:eu-repo/semantics/altIdentifier/eissn/1365-2133
dc.rights.none.fl_str_mv	Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	British Journal of Dermatology, 2022, vol. 187, núm. 3, p. 364-380 Articles publicats (D-I) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000–2014 in 59 countries (CONCORD-3)

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