Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant

Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospe...

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Autores: Jimenez-Sousa, Maria Angeles, Tamayo, Eduardo, Guzman-Fulgencio, Maria, Fernandez-Rodriguez, Amanda, Heredia-Rodríguez, María, Garcia-Alvarez, Monica, Bermejo-Martin, Jesús F, Pineda-Tenor, Daniel, Ruiz-Granado, Patricia, Alvarez-Fuente, Elisa, Gómez-Sánchez, Esther, Gómez-Herreras, José I, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17184
Acceso en línea:http://hdl.handle.net/20.500.12105/17184
Access Level:acceso abierto
Palabra clave:Kidney Transplantation
Adult
DNA, Mitochondrial
Female
Graft Rejection
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
White People
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network_acronym_str ES
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repository_id_str
spelling Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplantJimenez-Sousa, Maria AngelesTamayo, EduardoGuzman-Fulgencio, MariaFernandez-Rodriguez, AmandaHeredia-Rodríguez, MaríaGarcia-Alvarez, MonicaBermejo-Martin, Jesús FPineda-Tenor, DanielRuiz-Granado, PatriciaAlvarez-Fuente, ElisaGómez-Sánchez, EstherGómez-Herreras, José IResino, SalvadorKidney TransplantationAdultDNA, MitochondrialFemaleGraft RejectionHaplotypesHumansMaleMiddle AgedPolymorphism, Single NucleotideRetrospective StudiesWhite PeopleMitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospective observational study was carried out on 261 patients who received kidney transplant (114 had stable transplant and 147 patients developed chronic allograft dysfunction). DNA samples were genotyped for 14 mtDNA polymorphisms by using Sequenom's MassARRAY platform (San Diego, CA, USA). Only European white patients within the N macro-cluster were included. Patients with haplogroups V (odds ratio (OR)=0.32; p=0.037) and J (OR=0.36; p=0.038) showed lower odds for developing CRAD than patients with haplogroup H. After adjusting for the most significant variables, haplogroups V and J tended to statistical significance (p=0.091 and p=0.067 respectively). This is a preliminary study in which mtDNA haplogroups seem to be implicated in susceptibility or protection for developing chronic allograft dysfunction.Ivyspring International PublisherJunta de Castilla y León (España)Instituto de Salud Carlos III20242024-01-1720142014-01-0120142014-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/17184reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/171842026-06-12T12:43:37Z
dc.title.none.fl_str_mv Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
title Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
spellingShingle Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
Jimenez-Sousa, Maria Angeles
Kidney Transplantation
Adult
DNA, Mitochondrial
Female
Graft Rejection
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
White People
title_short Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
title_full Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
title_fullStr Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
title_full_unstemmed Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
title_sort Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
dc.creator.none.fl_str_mv Jimenez-Sousa, Maria Angeles
Tamayo, Eduardo
Guzman-Fulgencio, Maria
Fernandez-Rodriguez, Amanda
Heredia-Rodríguez, María
Garcia-Alvarez, Monica
Bermejo-Martin, Jesús F
Pineda-Tenor, Daniel
Ruiz-Granado, Patricia
Alvarez-Fuente, Elisa
Gómez-Sánchez, Esther
Gómez-Herreras, José I
Resino, Salvador
author Jimenez-Sousa, Maria Angeles
author_facet Jimenez-Sousa, Maria Angeles
Tamayo, Eduardo
Guzman-Fulgencio, Maria
Fernandez-Rodriguez, Amanda
Heredia-Rodríguez, María
Garcia-Alvarez, Monica
Bermejo-Martin, Jesús F
Pineda-Tenor, Daniel
Ruiz-Granado, Patricia
Alvarez-Fuente, Elisa
Gómez-Sánchez, Esther
Gómez-Herreras, José I
Resino, Salvador
author_role author
author2 Tamayo, Eduardo
Guzman-Fulgencio, Maria
Fernandez-Rodriguez, Amanda
Heredia-Rodríguez, María
Garcia-Alvarez, Monica
Bermejo-Martin, Jesús F
Pineda-Tenor, Daniel
Ruiz-Granado, Patricia
Alvarez-Fuente, Elisa
Gómez-Sánchez, Esther
Gómez-Herreras, José I
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Junta de Castilla y León (España)
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Kidney Transplantation
Adult
DNA, Mitochondrial
Female
Graft Rejection
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
White People
topic Kidney Transplantation
Adult
DNA, Mitochondrial
Female
Graft Rejection
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
White People
description Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospective observational study was carried out on 261 patients who received kidney transplant (114 had stable transplant and 147 patients developed chronic allograft dysfunction). DNA samples were genotyped for 14 mtDNA polymorphisms by using Sequenom's MassARRAY platform (San Diego, CA, USA). Only European white patients within the N macro-cluster were included. Patients with haplogroups V (odds ratio (OR)=0.32; p=0.037) and J (OR=0.36; p=0.038) showed lower odds for developing CRAD than patients with haplogroup H. After adjusting for the most significant variables, haplogroups V and J tended to statistical significance (p=0.091 and p=0.067 respectively). This is a preliminary study in which mtDNA haplogroups seem to be implicated in susceptibility or protection for developing chronic allograft dysfunction.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
2014
2014-01-01
2024
2024-01-17
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17184
url http://hdl.handle.net/20.500.12105/17184
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ivyspring International Publisher
publisher.none.fl_str_mv Ivyspring International Publisher
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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