Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant

Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospe...

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Detalles Bibliográficos
Autores: Jimenez-Sousa, Maria Angeles, Tamayo, Eduardo, Guzman-Fulgencio, Maria, Fernandez-Rodriguez, Amanda, Heredia-Rodríguez, María, Garcia-Alvarez, Monica, Bermejo-Martin, Jesús F, Pineda-Tenor, Daniel, Ruiz-Granado, Patricia, Alvarez-Fuente, Elisa, Gómez-Sánchez, Esther, Gómez-Herreras, José I, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17184
Acceso en línea:http://hdl.handle.net/20.500.12105/17184
Access Level:acceso abierto
Palabra clave:Kidney Transplantation
Adult
DNA, Mitochondrial
Female
Graft Rejection
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
White People
Descripción
Sumario:Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospective observational study was carried out on 261 patients who received kidney transplant (114 had stable transplant and 147 patients developed chronic allograft dysfunction). DNA samples were genotyped for 14 mtDNA polymorphisms by using Sequenom's MassARRAY platform (San Diego, CA, USA). Only European white patients within the N macro-cluster were included. Patients with haplogroups V (odds ratio (OR)=0.32; p=0.037) and J (OR=0.36; p=0.038) showed lower odds for developing CRAD than patients with haplogroup H. After adjusting for the most significant variables, haplogroups V and J tended to statistical significance (p=0.091 and p=0.067 respectively). This is a preliminary study in which mtDNA haplogroups seem to be implicated in susceptibility or protection for developing chronic allograft dysfunction.

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