Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments

Purpose: To assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to...

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Detalles Bibliográficos
Autores: Trujillo Guillén, Macarena, Castellví Fernández, Quim, Burdío Pinilla, Fernando, Ivorra Cano, Antoni, 1974-, Andaluz, Anna, Sanchez Velazquez Patricia, Berjano, Enrique J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26252
Acceso en línea:http://hdl.handle.net/10230/26252
http://dx.doi.org/10.3109/02656736.2013.777854
Access Level:acceso abierto
Palabra clave:Electroporation
Radiofrequency ablation
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spelling Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experimentsTrujillo Guillén, MacarenaCastellví Fernández, QuimBurdío Pinilla, FernandoIvorra Cano, Antoni, 1974-Andaluz, AnnaSanchez Velazquez PatriciaBerjano, Enrique J.ElectroporationRadiofrequency ablationPurpose: To assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to increase the coagulation volume in comparison to that created exclusively by RFA./nMaterials and methods: Modeling study and in vivo experimental study. A Cool-tip RF applicator was used both for EP and RFA./nResults: Overall, the results did not show any synergy effect from using the hybrid technique. Applying EP pulses prior to RFA did not increase the coagulation zone obtained and the lesions were almost identical. Additional computer simulations provided an explanation for this; the effect of reducing blood perfusion by thermal damage during RFA completely masks the effect of reducing blood perfusion by EP. This is because both thermal damage and EP affect the same zone, i.e. the tissue around the electrode./nConclusions: Our computer modeling and in vivo experimental findings suggest that the combination of EP and RFA with monopolar applicators does not provide an additional benefit over the use of RFA alone.This work received financial support from the Spanish “Plan Nacional de I+D+I del Ministerio de Ciencia e Innovación” Grants No. TEC2011-27133-C02-01,02 and TEC2010-17285, from the European Commission through the Marie Curie IRG grant TAMIVIVE (256376) and from the Universitat Politècnica de València (INNOVA11-01-5502; and PAID-06-11 Ref. 1988). The linguistic revision of this paper was funded by the Universitat Politècnica de València, Spain.Taylor & Francis (Routledge)201620162013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26252http://dx.doi.org/10.3109/02656736.2013.777854reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInternational journal of hyperthermia. 2013;29(3):211-18.info:eu-repo/grantAgreement/ES/3PN/TEC2011-27133-C02-01info:eu-repo/grantAgreement/ES/3PN/TEC2011-27133-C02-02info:eu-repo/grantAgreement/EC/FP7/256376© Taylor & Francis. This is an electronic version of an article published in Trujilo M, Castellví Q, Burdío F, Sánchez-Velázquez P, Ivorra A, Andaluz A, Berjano E. Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? : a feasibility study based on theoretical modelling and in vivo experiments. Int J Hyperthermia. 2013;29(3):211-18. International Journal of Hyperthermia is available online at: www.tandfonline.com http://dx.doi.org/10.3109/02656736.2013.777854info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/262522026-06-12T07:21:37Z
dc.title.none.fl_str_mv Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
spellingShingle Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
Trujillo Guillén, Macarena
Electroporation
Radiofrequency ablation
title_short Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_full Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_fullStr Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_full_unstemmed Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_sort Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
dc.creator.none.fl_str_mv Trujillo Guillén, Macarena
Castellví Fernández, Quim
Burdío Pinilla, Fernando
Ivorra Cano, Antoni, 1974-
Andaluz, Anna
Sanchez Velazquez Patricia
Berjano, Enrique J.
author Trujillo Guillén, Macarena
author_facet Trujillo Guillén, Macarena
Castellví Fernández, Quim
Burdío Pinilla, Fernando
Ivorra Cano, Antoni, 1974-
Andaluz, Anna
Sanchez Velazquez Patricia
Berjano, Enrique J.
author_role author
author2 Castellví Fernández, Quim
Burdío Pinilla, Fernando
Ivorra Cano, Antoni, 1974-
Andaluz, Anna
Sanchez Velazquez Patricia
Berjano, Enrique J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Electroporation
Radiofrequency ablation
topic Electroporation
Radiofrequency ablation
description Purpose: To assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to increase the coagulation volume in comparison to that created exclusively by RFA./nMaterials and methods: Modeling study and in vivo experimental study. A Cool-tip RF applicator was used both for EP and RFA./nResults: Overall, the results did not show any synergy effect from using the hybrid technique. Applying EP pulses prior to RFA did not increase the coagulation zone obtained and the lesions were almost identical. Additional computer simulations provided an explanation for this; the effect of reducing blood perfusion by thermal damage during RFA completely masks the effect of reducing blood perfusion by EP. This is because both thermal damage and EP affect the same zone, i.e. the tissue around the electrode./nConclusions: Our computer modeling and in vivo experimental findings suggest that the combination of EP and RFA with monopolar applicators does not provide an additional benefit over the use of RFA alone.
publishDate 2013
dc.date.none.fl_str_mv 2013
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26252
http://dx.doi.org/10.3109/02656736.2013.777854
url http://hdl.handle.net/10230/26252
http://dx.doi.org/10.3109/02656736.2013.777854
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International journal of hyperthermia. 2013;29(3):211-18.
info:eu-repo/grantAgreement/ES/3PN/TEC2011-27133-C02-01
info:eu-repo/grantAgreement/ES/3PN/TEC2011-27133-C02-02
info:eu-repo/grantAgreement/EC/FP7/256376
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis (Routledge)
publisher.none.fl_str_mv Taylor & Francis (Routledge)
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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