EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial

Background: Digital health interventions have shown promise for improving quality of life, especially in the short term after treatment. However, evidence regarding long-term breast cancer survivors (LT-BCSs; disease free >5 years) remains limited. This study aimed to evaluate the effectivene...

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Autores: Pimentel Parra, Gustavo Adolfo, Soto Ruiz, María Nelia, Escalada Hernández, Paula, San Martín Rodríguez, Leticia, García Vivar, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:dnet:academicae__::3217319513ebb6823f6bafdba270d49b
Acceso en línea:https://hdl.handle.net/2454/56800
Access Level:acceso abierto
Palabra clave:Breast cancer
Long-term care
Quality of life
Survivorship
EHealth
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spelling EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trialPimentel Parra, Gustavo AdolfoSoto Ruiz, María NeliaEscalada Hernández, PaulaSan Martín Rodríguez, LeticiaGarcía Vivar, CristinaBreast cancerLong-term careQuality of lifeSurvivorshipEHealthBackground: Digital health interventions have shown promise for improving quality of life, especially in the short term after treatment. However, evidence regarding long-term breast cancer survivors (LT-BCSs; disease free >5 years) remains limited. This study aimed to evaluate the effectiveness of an eHealth intervention targeting health promotion and late sequelae management to improve LT-BCSs’ quality of life. Methods: In a randomized controlled clinical trial, 201 LT-BCSs (mean ¼ 11 years posttreatment) were randomly assigned to an intervention group (n ¼ 102) using the CUMACA-M mobile application with specific health advice and recommendations for LT-BCSs, or a control group (n ¼ 99) receiving usual care. Quality of life was measured with the Quality of Life–Cancer Survivors (QOL-CS) scale at baseline and after 3months. Analyses followed an intention-to-treat approach using t tests, nonparametric tests, and effect sizes. Results: At 3 months, no statistically or clinically significant differences between the groups in the overall quality of life score (QOL-CS) were found (difference-in-differences ¼ 0.11; 95% confidence interval ¼ −0.10 to 0.32; P ¼ .303). In the intervention group, a small intragroup decrease in spiritual well-being was observed (−0.25; −0.49 to −0.02), of uncertain clinical significance; no significant differences between groups were detected. Conclusions: This eHealth intervention did not improve the quality of life of LT-BCSs, suggesting that more personalized, interactive, or professionally supported strategies may be needed. Future research should evaluate the long-term outcomes and effectiveness of hybrid or personalized digital strategies in this population. Trial Registration: ClinicalTrials.gov NCT05322460;This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI21/00894 and co-funded by the European Union. The article processing charges for this publication were covered by the Public University of Navarre under the agreement established with the Conference of Rectors of Spanish Universities (CRUE).Oxford University PressCiencias de la SaludOsasun ZientziakUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/56800reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00894© The Author(s) 2026. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence, which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:academicae__::3217319513ebb6823f6bafdba270d49b2026-06-17T12:41:47Z
dc.title.none.fl_str_mv EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
title EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
spellingShingle EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
Pimentel Parra, Gustavo Adolfo
Breast cancer
Long-term care
Quality of life
Survivorship
EHealth
title_short EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
title_full EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
title_fullStr EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
title_full_unstemmed EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
title_sort EHealth intervention for quality of life in long-term breast cancer survivors: randomized controlled trial
dc.creator.none.fl_str_mv Pimentel Parra, Gustavo Adolfo
Soto Ruiz, María Nelia
Escalada Hernández, Paula
San Martín Rodríguez, Leticia
García Vivar, Cristina
author Pimentel Parra, Gustavo Adolfo
author_facet Pimentel Parra, Gustavo Adolfo
Soto Ruiz, María Nelia
Escalada Hernández, Paula
San Martín Rodríguez, Leticia
García Vivar, Cristina
author_role author
author2 Soto Ruiz, María Nelia
Escalada Hernández, Paula
San Martín Rodríguez, Leticia
García Vivar, Cristina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.subject.none.fl_str_mv Breast cancer
Long-term care
Quality of life
Survivorship
EHealth
topic Breast cancer
Long-term care
Quality of life
Survivorship
EHealth
description Background: Digital health interventions have shown promise for improving quality of life, especially in the short term after treatment. However, evidence regarding long-term breast cancer survivors (LT-BCSs; disease free >5 years) remains limited. This study aimed to evaluate the effectiveness of an eHealth intervention targeting health promotion and late sequelae management to improve LT-BCSs’ quality of life. Methods: In a randomized controlled clinical trial, 201 LT-BCSs (mean ¼ 11 years posttreatment) were randomly assigned to an intervention group (n ¼ 102) using the CUMACA-M mobile application with specific health advice and recommendations for LT-BCSs, or a control group (n ¼ 99) receiving usual care. Quality of life was measured with the Quality of Life–Cancer Survivors (QOL-CS) scale at baseline and after 3months. Analyses followed an intention-to-treat approach using t tests, nonparametric tests, and effect sizes. Results: At 3 months, no statistically or clinically significant differences between the groups in the overall quality of life score (QOL-CS) were found (difference-in-differences ¼ 0.11; 95% confidence interval ¼ −0.10 to 0.32; P ¼ .303). In the intervention group, a small intragroup decrease in spiritual well-being was observed (−0.25; −0.49 to −0.02), of uncertain clinical significance; no significant differences between groups were detected. Conclusions: This eHealth intervention did not improve the quality of life of LT-BCSs, suggesting that more personalized, interactive, or professionally supported strategies may be needed. Future research should evaluate the long-term outcomes and effectiveness of hybrid or personalized digital strategies in this population. Trial Registration: ClinicalTrials.gov NCT05322460;
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/56800
url https://hdl.handle.net/2454/56800
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00894
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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