Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection
Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal in...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Servizo Galego de Saúde (SERGAS) |
| Repositorio: | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| OAI Identifier: | oai:runa.sergas.gal:20.500.11940/14983 |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/30171206/ http://hdl.handle.net/20.500.11940/14983 |
| Access Level: | acceso abierto |
| Palabra clave: | CD4 Lymphocyte Count Intestinal Mucosa Dysbiosis HIV Infections disbacteriosis mucosa intestinal recuento de linfocitos CD4 infecciones por VIH CHUVI Instituto de Investigación Sanitaria Galicia Sur |
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Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infectionGuillén, YolandaNogueira-Julian, MarcRivera, JavierCasadellá, MariaZevin, Alexander SRocafort, MuntsaParera, MarionaRodríguez, CristinaArumí, MarçalCarrillo, JorgeMothe, BeatrizEstany, CarlaColl, JosepBravo, IsabelHerrero, CristinaSaz, JorgeSirera, GuillemTorrella, AriadnaNavarro, JordiCRESPO CASAL, MANUELNegredo, EugèniaBrander, ChristianBlanco, JuliàCalle, María LuzKlatt, Nichole RClotet, BonaventuraParedes, RogerCD4 Lymphocyte CountIntestinal MucosaDysbiosisHIV Infectionsdisbacteriosismucosa intestinalrecuento de linfocitos CD4infecciones por VIHCHUVIInstituto de Investigación Sanitaria Galicia SurHuman immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. As in other diseases involving intestinal inflammation, the gut microbiomes of subjects with LGC were enriched in gram-negative Bacteroides, acetogenic bacteria and Proteobacteria, which are able to metabolize reactive oxygen and nitrogen species; and were depleted in oxygen-sensitive methanogenic archaea and sulfate-reducing bacteria. Interestingly, subjects with LGC also showed increased butyrate levels in direct fecal measurements, consistent with enrichment in Roseburia intestinalis despite reductions in other butyrate producers. The microbiomes of subjects with LGC were also enriched in bacterial virulence factors, as well as in genes associated with beta-lactam, lincosamide, tetracycline, and macrolide resistance. Thus, low nadir CD4+ T-cell counts, rather than HIV-1 serostatus per se, predict the presence of gut dysbiosis in HIV-1 infected subjects. Such dysbiosis does not display obvious HIV-specific features; instead, it shares many similarities with other diseases featuring gut inflammation.Fundació Glòria SolerFundació Catalunya-La PedreraGala SIDA 2015-2016Nit per la Recerca a la Catalunya Central 2015 editionPeople in Red-Barcelona 2016 editionRED de SIDA RD16/0025/0041ISCIIIEuropean Regional Develpment Fund (ERDF)Agencia de Gestio d´Ajuts Universitaris i de Recerca (AGAUR)Secretaria d´Universitats i Recerca del Departament d´Economia i Coneixement de la Generalitat de CatalunyaMinisterio de Economia y Competitividad. EspañaUniversidad de Whashington2019info:eu-repo/semantics/articlehttps://pubmed.ncbi.nlm.nih.gov/30171206/http://hdl.handle.net/20.500.11940/14983reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/149832026-06-12T08:40:47Z |
| dc.title.none.fl_str_mv |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
| title |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
| spellingShingle |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection Guillén, Yolanda CD4 Lymphocyte Count Intestinal Mucosa Dysbiosis HIV Infections disbacteriosis mucosa intestinal recuento de linfocitos CD4 infecciones por VIH CHUVI Instituto de Investigación Sanitaria Galicia Sur |
| title_short |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
| title_full |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
| title_fullStr |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
| title_full_unstemmed |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
| title_sort |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
| dc.creator.none.fl_str_mv |
Guillén, Yolanda Nogueira-Julian, Marc Rivera, Javier Casadellá, Maria Zevin, Alexander S Rocafort, Muntsa Parera, Mariona Rodríguez, Cristina Arumí, Marçal Carrillo, Jorge Mothe, Beatriz Estany, Carla Coll, Josep Bravo, Isabel Herrero, Cristina Saz, Jorge Sirera, Guillem Torrella, Ariadna Navarro, Jordi CRESPO CASAL, MANUEL Negredo, Eugènia Brander, Christian Blanco, Julià Calle, María Luz Klatt, Nichole R Clotet, Bonaventura Paredes, Roger |
| author |
Guillén, Yolanda |
| author_facet |
Guillén, Yolanda Nogueira-Julian, Marc Rivera, Javier Casadellá, Maria Zevin, Alexander S Rocafort, Muntsa Parera, Mariona Rodríguez, Cristina Arumí, Marçal Carrillo, Jorge Mothe, Beatriz Estany, Carla Coll, Josep Bravo, Isabel Herrero, Cristina Saz, Jorge Sirera, Guillem Torrella, Ariadna Navarro, Jordi CRESPO CASAL, MANUEL Negredo, Eugènia Brander, Christian Blanco, Julià Calle, María Luz Klatt, Nichole R Clotet, Bonaventura Paredes, Roger |
| author_role |
author |
| author2 |
Nogueira-Julian, Marc Rivera, Javier Casadellá, Maria Zevin, Alexander S Rocafort, Muntsa Parera, Mariona Rodríguez, Cristina Arumí, Marçal Carrillo, Jorge Mothe, Beatriz Estany, Carla Coll, Josep Bravo, Isabel Herrero, Cristina Saz, Jorge Sirera, Guillem Torrella, Ariadna Navarro, Jordi CRESPO CASAL, MANUEL Negredo, Eugènia Brander, Christian Blanco, Julià Calle, María Luz Klatt, Nichole R Clotet, Bonaventura Paredes, Roger |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CD4 Lymphocyte Count Intestinal Mucosa Dysbiosis HIV Infections disbacteriosis mucosa intestinal recuento de linfocitos CD4 infecciones por VIH CHUVI Instituto de Investigación Sanitaria Galicia Sur |
| topic |
CD4 Lymphocyte Count Intestinal Mucosa Dysbiosis HIV Infections disbacteriosis mucosa intestinal recuento de linfocitos CD4 infecciones por VIH CHUVI Instituto de Investigación Sanitaria Galicia Sur |
| description |
Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. As in other diseases involving intestinal inflammation, the gut microbiomes of subjects with LGC were enriched in gram-negative Bacteroides, acetogenic bacteria and Proteobacteria, which are able to metabolize reactive oxygen and nitrogen species; and were depleted in oxygen-sensitive methanogenic archaea and sulfate-reducing bacteria. Interestingly, subjects with LGC also showed increased butyrate levels in direct fecal measurements, consistent with enrichment in Roseburia intestinalis despite reductions in other butyrate producers. The microbiomes of subjects with LGC were also enriched in bacterial virulence factors, as well as in genes associated with beta-lactam, lincosamide, tetracycline, and macrolide resistance. Thus, low nadir CD4+ T-cell counts, rather than HIV-1 serostatus per se, predict the presence of gut dysbiosis in HIV-1 infected subjects. Such dysbiosis does not display obvious HIV-specific features; instead, it shares many similarities with other diseases featuring gut inflammation. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://pubmed.ncbi.nlm.nih.gov/30171206/ http://hdl.handle.net/20.500.11940/14983 |
| url |
https://pubmed.ncbi.nlm.nih.gov/30171206/ http://hdl.handle.net/20.500.11940/14983 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas instname:Servizo Galego de Saúde (SERGAS) |
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Servizo Galego de Saúde (SERGAS) |
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RUNA. Repositorio da Consellería de Sanidade e Sergas |
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RUNA. Repositorio da Consellería de Sanidade e Sergas |
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