Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection

Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal in...

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Detalles Bibliográficos
Autores: Guillén, Yolanda, Nogueira-Julian, Marc, Rivera, Javier, Casadellá, Maria, Zevin, Alexander S, Rocafort, Muntsa, Parera, Mariona, Rodríguez, Cristina, Arumí, Marçal, Carrillo, Jorge, Mothe, Beatriz, Estany, Carla, Coll, Josep, Bravo, Isabel, Herrero, Cristina, Saz, Jorge, Sirera, Guillem, Torrella, Ariadna, Navarro, Jordi, CRESPO CASAL, MANUEL, Negredo, Eugènia, Brander, Christian, Blanco, Julià, Calle, María Luz, Klatt, Nichole R, Clotet, Bonaventura, Paredes, Roger
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/14983
Acceso en línea:https://pubmed.ncbi.nlm.nih.gov/30171206/
http://hdl.handle.net/20.500.11940/14983
Access Level:acceso abierto
Palabra clave:CD4 Lymphocyte Count
Intestinal Mucosa
Dysbiosis
HIV Infections
disbacteriosis
mucosa intestinal
recuento de linfocitos CD4
infecciones por VIH
CHUVI
Instituto de Investigación Sanitaria Galicia Sur
Descripción
Sumario:Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. As in other diseases involving intestinal inflammation, the gut microbiomes of subjects with LGC were enriched in gram-negative Bacteroides, acetogenic bacteria and Proteobacteria, which are able to metabolize reactive oxygen and nitrogen species; and were depleted in oxygen-sensitive methanogenic archaea and sulfate-reducing bacteria. Interestingly, subjects with LGC also showed increased butyrate levels in direct fecal measurements, consistent with enrichment in Roseburia intestinalis despite reductions in other butyrate producers. The microbiomes of subjects with LGC were also enriched in bacterial virulence factors, as well as in genes associated with beta-lactam, lincosamide, tetracycline, and macrolide resistance. Thus, low nadir CD4+ T-cell counts, rather than HIV-1 serostatus per se, predict the presence of gut dysbiosis in HIV-1 infected subjects. Such dysbiosis does not display obvious HIV-specific features; instead, it shares many similarities with other diseases featuring gut inflammation.

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