Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial
Nutrition therapy is the cornerstone of treating diabetes mellitus. The inclusion of fish (particularly oily fish) at least two times per week is recommended by current international dietary guidelines for type 2 diabetes. In contrast to a large number of human studies examining the effects of oily...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/114307 |
| Acceso en línea: | https://hdl.handle.net/2445/114307 |
| Access Level: | acceso abierto |
| Palabra clave: | Sardines Dieta Diabetis Microbiota intestinal Alimentació Assaigs clínics Diet Diabetes Gastrointestinal microbiome Clinical trials |
| id |
ES_fd7ab2dc6e68b71dca130de2c42a30c4 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:2445/114307 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trialBalfegó Díaz, MarionaCanivell Fusté, SilviaHanzu, Felicia A.Sala Vila, AleixMartínez-Medina, MargaritaMurillo, SerafínMur, TeresaRuano, Elena G.Linares, FranciscaPorras, NuriaValladares, SilviaFontalba, MariaRoura Carvajal, ElenaNovials, AnnaHernández-Munain, CristinaAranda, GloriaSisó Almirall, AntoniRojo-Martínez, GemmaSimó, RafaelGomis, Ramon, 1946-SardinesDietaDiabetisMicrobiota intestinalAlimentacióAssaigs clínicsSardinesDietDiabetesGastrointestinal microbiomeDietClinical trialsNutrition therapy is the cornerstone of treating diabetes mellitus. The inclusion of fish (particularly oily fish) at least two times per week is recommended by current international dietary guidelines for type 2 diabetes. In contrast to a large number of human studies examining the effects of oily fish on different cardiovascular risk factors, little research on this topic is available in patients with type 2 diabetes. The aims of this pilot study were to investigate the effects of a sardine-enriched diet on metabolic control, adiponectin, inflammatory markers, erythrocyte membrane fatty acid (EMFA) composition, and gut microbiota in drug-naïve patients with type 2 diabetes. METHODS: 35 drug-naïve patients with type 2 diabetes were randomized to follow either a type 2 diabetes standard diet (control group: CG), or a standard diet enriched with 100 g of sardines 5 days a week (sardine group: SG) for 6 months. Anthropometric, dietary information, fasting glycated hemoglobin, glucose, insulin, adiponectin, inflammatory markers, EMFA and specific bacterial strains were determined before and after intervention. RESULTS: There were no significant differences in glycemic control between groups at the end of the study. Both groups decreased plasma insulin (SG: -35.3%, P = 0.01, CG: -22.6%, P = 0.02) and homeostasis model of assessment--insulin resistance (HOMA-IR) (SG: -39.2%, P = 0.007, CG: -21.8%, P = 0.04) at 6-months from baseline. However only SG increased adiponectin in plasma compared to baseline level (+40.7%, P = 0.04). The omega-3 index increased 2.6% in the SG compared to 0.6% in the CG (P = 0.001). Both dietary interventions decreased phylum Firmicutes (SG and CG: P = 0.04) and increased E. coli concentrations (SG: P = 0.01, CG: P = 0.03) at the end of the study from baseline, whereas SG decreased Firmicutes/Bacteroidetes ratio (P = 0.04) and increased Bacteroides-Prevotella (P = 0.004) compared to baseline. CONCLUSIONS: Although enriching diet with 100 g of sardines 5 days a week during 6 months to a type 2 diabetes standard diet seems to have neutral effects on glycemic control in drug-naïve patients with type 2 diabetes, this nutritional intervention could have beneficial effects on cardiovascular risk. Furthermore, both dietary interventions decreased HOMA-IR and altered gut microbiota composition of drug-naïve patients with type 2 diabetes.BioMed Central2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/114307Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s12944-016-0245-0Lipids In Health And Disease, 2016, vol. 15, num. 78, p. 1-11https://doi.org/10.1186/s12944-016-0245-0cc-by (c) Balfegó, Mariona et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1143072026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial |
| title |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial |
| spellingShingle |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial Balfegó Díaz, Mariona Sardines Dieta Diabetis Microbiota intestinal Alimentació Assaigs clínics Sardines Diet Diabetes Gastrointestinal microbiome Diet Clinical trials |
| title_short |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial |
| title_full |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial |
| title_fullStr |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial |
| title_full_unstemmed |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial |
| title_sort |
Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial |
| dc.creator.none.fl_str_mv |
Balfegó Díaz, Mariona Canivell Fusté, Silvia Hanzu, Felicia A. Sala Vila, Aleix Martínez-Medina, Margarita Murillo, Serafín Mur, Teresa Ruano, Elena G. Linares, Francisca Porras, Nuria Valladares, Silvia Fontalba, Maria Roura Carvajal, Elena Novials, Anna Hernández-Munain, Cristina Aranda, Gloria Sisó Almirall, Antoni Rojo-Martínez, Gemma Simó, Rafael Gomis, Ramon, 1946- |
| author |
Balfegó Díaz, Mariona |
| author_facet |
Balfegó Díaz, Mariona Canivell Fusté, Silvia Hanzu, Felicia A. Sala Vila, Aleix Martínez-Medina, Margarita Murillo, Serafín Mur, Teresa Ruano, Elena G. Linares, Francisca Porras, Nuria Valladares, Silvia Fontalba, Maria Roura Carvajal, Elena Novials, Anna Hernández-Munain, Cristina Aranda, Gloria Sisó Almirall, Antoni Rojo-Martínez, Gemma Simó, Rafael Gomis, Ramon, 1946- |
| author_role |
author |
| author2 |
Canivell Fusté, Silvia Hanzu, Felicia A. Sala Vila, Aleix Martínez-Medina, Margarita Murillo, Serafín Mur, Teresa Ruano, Elena G. Linares, Francisca Porras, Nuria Valladares, Silvia Fontalba, Maria Roura Carvajal, Elena Novials, Anna Hernández-Munain, Cristina Aranda, Gloria Sisó Almirall, Antoni Rojo-Martínez, Gemma Simó, Rafael Gomis, Ramon, 1946- |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Sardines Dieta Diabetis Microbiota intestinal Alimentació Assaigs clínics Sardines Diet Diabetes Gastrointestinal microbiome Diet Clinical trials |
| topic |
Sardines Dieta Diabetis Microbiota intestinal Alimentació Assaigs clínics Sardines Diet Diabetes Gastrointestinal microbiome Diet Clinical trials |
| description |
Nutrition therapy is the cornerstone of treating diabetes mellitus. The inclusion of fish (particularly oily fish) at least two times per week is recommended by current international dietary guidelines for type 2 diabetes. In contrast to a large number of human studies examining the effects of oily fish on different cardiovascular risk factors, little research on this topic is available in patients with type 2 diabetes. The aims of this pilot study were to investigate the effects of a sardine-enriched diet on metabolic control, adiponectin, inflammatory markers, erythrocyte membrane fatty acid (EMFA) composition, and gut microbiota in drug-naïve patients with type 2 diabetes. METHODS: 35 drug-naïve patients with type 2 diabetes were randomized to follow either a type 2 diabetes standard diet (control group: CG), or a standard diet enriched with 100 g of sardines 5 days a week (sardine group: SG) for 6 months. Anthropometric, dietary information, fasting glycated hemoglobin, glucose, insulin, adiponectin, inflammatory markers, EMFA and specific bacterial strains were determined before and after intervention. RESULTS: There were no significant differences in glycemic control between groups at the end of the study. Both groups decreased plasma insulin (SG: -35.3%, P = 0.01, CG: -22.6%, P = 0.02) and homeostasis model of assessment--insulin resistance (HOMA-IR) (SG: -39.2%, P = 0.007, CG: -21.8%, P = 0.04) at 6-months from baseline. However only SG increased adiponectin in plasma compared to baseline level (+40.7%, P = 0.04). The omega-3 index increased 2.6% in the SG compared to 0.6% in the CG (P = 0.001). Both dietary interventions decreased phylum Firmicutes (SG and CG: P = 0.04) and increased E. coli concentrations (SG: P = 0.01, CG: P = 0.03) at the end of the study from baseline, whereas SG decreased Firmicutes/Bacteroidetes ratio (P = 0.04) and increased Bacteroides-Prevotella (P = 0.004) compared to baseline. CONCLUSIONS: Although enriching diet with 100 g of sardines 5 days a week during 6 months to a type 2 diabetes standard diet seems to have neutral effects on glycemic control in drug-naïve patients with type 2 diabetes, this nutritional intervention could have beneficial effects on cardiovascular risk. Furthermore, both dietary interventions decreased HOMA-IR and altered gut microbiota composition of drug-naïve patients with type 2 diabetes. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2017 2017 2017 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/114307 |
| url |
https://hdl.handle.net/2445/114307 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1186/s12944-016-0245-0 Lipids In Health And Disease, 2016, vol. 15, num. 78, p. 1-11 https://doi.org/10.1186/s12944-016-0245-0 |
| dc.rights.none.fl_str_mv |
cc-by (c) Balfegó, Mariona et al., 2016 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Balfegó, Mariona et al., 2016 http://creativecommons.org/licenses/by/3.0/es |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
11 p. application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
| publisher.none.fl_str_mv |
BioMed Central |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869425543630290944 |
| score |
15,811543 |