Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation

[EN]The aim of the present study was to investigate the effect of the presence of the water-soluble polymer polyvinylpyrrolidone (PVP) MW=24,000 g/mol, on the complexing of the anti-inflammatory drug nabumetone, with β-cyclodextrin (β-CD). The data show that the polymer interacts with the free nabum...

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Autores: Valero Juan, Margarita, Tejedor, Javier, Rodríguez, Licesio J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:dnet:gredos______::4b1b746acb209739b0c7c93953106ba4
Acceso en línea:http://hdl.handle.net/10366/171025
Access Level:acceso abierto
Palabra clave:Nabumetone
b-cyclodextrin
Polyvinylpyrrolidone
Ternary inclusion complex
Fluorescence
fluorescencia
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spelling Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formationValero Juan, MargaritaTejedor, JavierRodríguez, Licesio J.Nabumetoneb-cyclodextrinPolyvinylpyrrolidoneTernary inclusion complexFluorescenceFluorescencefluorescencia[EN]The aim of the present study was to investigate the effect of the presence of the water-soluble polymer polyvinylpyrrolidone (PVP) MW=24,000 g/mol, on the complexing of the anti-inflammatory drug nabumetone, with β-cyclodextrin (β-CD). The data show that the polymer interacts with the free nabumetone and with the nabumetone:β-CD inclusion complex, in both cases with a stoichiometry of 1:1. The interaction constants are 1.3×104 M-1 and 1.6×104 M-1, respectively. The presence of PVP, changes the drug:cyclodextrin interaction, a nabumetone:(β-CD)2:PVP complex being formed. In addition, the presence of PVP, produces a strong increase in the global binding constant, β2=(22.12±0.22)×106 M-2 at 1% PVP. In the ternary complex, the nabumetone is wrapped at both ends for the β-CD. In this complex the polymer seems to act as a bridge between both β-CD molecules that bind the nabumetone.Elsevier202620262006info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10366/171025reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:gredos______::4b1b746acb209739b0c7c93953106ba42026-06-07T06:28:51Z
dc.title.none.fl_str_mv Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
title Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
spellingShingle Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
Valero Juan, Margarita
Nabumetone
b-cyclodextrin
Polyvinylpyrrolidone
Ternary inclusion complex
Fluorescence
Fluorescence
fluorescencia
title_short Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
title_full Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
title_fullStr Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
title_full_unstemmed Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
title_sort Encapsulation of nabumetone by means of -drug: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
dc.creator.none.fl_str_mv Valero Juan, Margarita
Tejedor, Javier
Rodríguez, Licesio J.
author Valero Juan, Margarita
author_facet Valero Juan, Margarita
Tejedor, Javier
Rodríguez, Licesio J.
author_role author
author2 Tejedor, Javier
Rodríguez, Licesio J.
author2_role author
author
dc.subject.none.fl_str_mv Nabumetone
b-cyclodextrin
Polyvinylpyrrolidone
Ternary inclusion complex
Fluorescence
Fluorescence
fluorescencia
topic Nabumetone
b-cyclodextrin
Polyvinylpyrrolidone
Ternary inclusion complex
Fluorescence
Fluorescence
fluorescencia
description [EN]The aim of the present study was to investigate the effect of the presence of the water-soluble polymer polyvinylpyrrolidone (PVP) MW=24,000 g/mol, on the complexing of the anti-inflammatory drug nabumetone, with β-cyclodextrin (β-CD). The data show that the polymer interacts with the free nabumetone and with the nabumetone:β-CD inclusion complex, in both cases with a stoichiometry of 1:1. The interaction constants are 1.3×104 M-1 and 1.6×104 M-1, respectively. The presence of PVP, changes the drug:cyclodextrin interaction, a nabumetone:(β-CD)2:PVP complex being formed. In addition, the presence of PVP, produces a strong increase in the global binding constant, β2=(22.12±0.22)×106 M-2 at 1% PVP. In the ternary complex, the nabumetone is wrapped at both ends for the β-CD. In this complex the polymer seems to act as a bridge between both β-CD molecules that bind the nabumetone.
publishDate 2006
dc.date.none.fl_str_mv 2006
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/171025
url http://hdl.handle.net/10366/171025
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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