Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria

Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation of metal-enhanced 1O2 nanoplatforms exploiting the lightning rod effect, or plasmon hot s...

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Detalles Bibliográficos
Autores: Macia, Nicolas, Bresolí-Obach, Roger, Nonell, Santi, Heyne, Belinda
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/5319
Acceso en línea:http://hdl.handle.net/20.500.14342/5319
https://doi.org/10.1021/jacs.8b12206
Access Level:acceso abierto
Palabra clave:Bacteria
Metals
Nanoparticles
Photosensitization
Silica
Bacteris
Metalls
Nanopartícules
Fotosensibilització (Biologia)
Sílice
539
54
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oai_identifier_str oai:dau.url.edu:20.500.14342/5319
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repository_id_str
spelling Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of BacteriaMacia, NicolasBresolí-Obach, RogerNonell, SantiHeyne, BelindaBacteriaMetalsNanoparticlesPhotosensitizationSilicaBacterisMetallsNanopartículesFotosensibilització (Biologia)Sílice53954Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation of metal-enhanced 1O2 nanoplatforms exploiting the lightning rod effect, or plasmon hot spots, in anisotropic (nonspherical) metal nanoparticles. We describe the synthesis of Rose Bengal-decorated silica-coated silver nanocubes (Ag@SiO2-RB NCs) with silica shell thicknesses ranging from 5 to 50 nm based on an optimized protocol yielding highly homogeneous Ag NCs. Steady-state and time-resolved 1O2 measurements demonstrate not only the silica shell thickness dependence on the metal-enhanced 1O2 production phenomenon but also the superiority of this next generation of nanoplatforms. A maximum enhancement of 1O2 of approximately 12-fold is observed with a 10 nm silica shell, which is among the largest 1O2 production metal enhancement factors ever reported for a colloidal suspension of nanoparticles. Finally, the Ag@SiO2-RB NCs were benchmarked against the Ag@SiO2-RB nanospheres previously reported by our group, and the superior 1O2 production of Ag@SiO2-RB NCs resulted in improved antimicrobial activities in photodynamic inactivation experiments using both Gram-positive and -negative bacteria model strains.info:eu-repo/semantics/acceptedVersionAmerican Chemical SocietyUniversitat Ramon Llull. IQS202520252018info:eu-repo/semantics/articlep.11application/pdfhttp://hdl.handle.net/20.500.14342/5319https://doi.org/10.1021/jacs.8b12206reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésJournal of the American Chemical Society 2019, 141 (1), 684–692info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-R© American Chemical SocietyAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/53192026-06-21T06:40:37Z
dc.title.none.fl_str_mv Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
title Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
spellingShingle Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
Macia, Nicolas
Bacteria
Metals
Nanoparticles
Photosensitization
Silica
Bacteris
Metalls
Nanopartícules
Fotosensibilització (Biologia)
Sílice
539
54
title_short Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
title_full Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
title_fullStr Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
title_full_unstemmed Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
title_sort Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
dc.creator.none.fl_str_mv Macia, Nicolas
Bresolí-Obach, Roger
Nonell, Santi
Heyne, Belinda
author Macia, Nicolas
author_facet Macia, Nicolas
Bresolí-Obach, Roger
Nonell, Santi
Heyne, Belinda
author_role author
author2 Bresolí-Obach, Roger
Nonell, Santi
Heyne, Belinda
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Bacteria
Metals
Nanoparticles
Photosensitization
Silica
Bacteris
Metalls
Nanopartícules
Fotosensibilització (Biologia)
Sílice
539
54
topic Bacteria
Metals
Nanoparticles
Photosensitization
Silica
Bacteris
Metalls
Nanopartícules
Fotosensibilització (Biologia)
Sílice
539
54
description Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation of metal-enhanced 1O2 nanoplatforms exploiting the lightning rod effect, or plasmon hot spots, in anisotropic (nonspherical) metal nanoparticles. We describe the synthesis of Rose Bengal-decorated silica-coated silver nanocubes (Ag@SiO2-RB NCs) with silica shell thicknesses ranging from 5 to 50 nm based on an optimized protocol yielding highly homogeneous Ag NCs. Steady-state and time-resolved 1O2 measurements demonstrate not only the silica shell thickness dependence on the metal-enhanced 1O2 production phenomenon but also the superiority of this next generation of nanoplatforms. A maximum enhancement of 1O2 of approximately 12-fold is observed with a 10 nm silica shell, which is among the largest 1O2 production metal enhancement factors ever reported for a colloidal suspension of nanoparticles. Finally, the Ag@SiO2-RB NCs were benchmarked against the Ag@SiO2-RB nanospheres previously reported by our group, and the superior 1O2 production of Ag@SiO2-RB NCs resulted in improved antimicrobial activities in photodynamic inactivation experiments using both Gram-positive and -negative bacteria model strains.
publishDate 2018
dc.date.none.fl_str_mv 2018
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5319
https://doi.org/10.1021/jacs.8b12206
url http://hdl.handle.net/20.500.14342/5319
https://doi.org/10.1021/jacs.8b12206
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of the American Chemical Society 2019, 141 (1), 684–692
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-R
dc.rights.none.fl_str_mv © American Chemical Society
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © American Chemical Society
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv p.11
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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