Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria
Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation of metal-enhanced 1O2 nanoplatforms exploiting the lightning rod effect, or plasmon hot s...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.14342/5319 |
| Acceso en línea: | http://hdl.handle.net/20.500.14342/5319 https://doi.org/10.1021/jacs.8b12206 |
| Access Level: | acceso abierto |
| Palabra clave: | Bacteria Metals Nanoparticles Photosensitization Silica Bacteris Metalls Nanopartícules Fotosensibilització (Biologia) Sílice 539 54 |
| Sumario: | Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation of metal-enhanced 1O2 nanoplatforms exploiting the lightning rod effect, or plasmon hot spots, in anisotropic (nonspherical) metal nanoparticles. We describe the synthesis of Rose Bengal-decorated silica-coated silver nanocubes (Ag@SiO2-RB NCs) with silica shell thicknesses ranging from 5 to 50 nm based on an optimized protocol yielding highly homogeneous Ag NCs. Steady-state and time-resolved 1O2 measurements demonstrate not only the silica shell thickness dependence on the metal-enhanced 1O2 production phenomenon but also the superiority of this next generation of nanoplatforms. A maximum enhancement of 1O2 of approximately 12-fold is observed with a 10 nm silica shell, which is among the largest 1O2 production metal enhancement factors ever reported for a colloidal suspension of nanoparticles. Finally, the Ag@SiO2-RB NCs were benchmarked against the Ag@SiO2-RB nanospheres previously reported by our group, and the superior 1O2 production of Ag@SiO2-RB NCs resulted in improved antimicrobial activities in photodynamic inactivation experiments using both Gram-positive and -negative bacteria model strains. |
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