Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14

Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting...

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Autores: Broberg, Eeva K, Hungnes, Olav, Schweiger, Brunhilde, Prosenc, Katarina, Daniels, Rod, Guiomar, Raquel, Ikonen, Niina, Kossyvakis, Athanasios, Pozo Sanchez, Francisco, Puzelli, Simona, Thomas, Isabelle, Waters, Allison, Wiman, Åsa, Meijer, Adam
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6645
Acceso en línea:http://hdl.handle.net/20.500.12105/6645
Access Level:acceso abierto
Palabra clave:Adolescent
Adult
Age Distribution
Aged
Child
Child, Preschool
Epidemiological Monitoring
Europe
European Union
Feasibility Studies
Hemagglutination Inhibition Tests
Humans
Influenza A Virus, H1N1 Subtype
Hospitalization
Influenza A Virus, H3N2 Subtype
Influenza Vaccines
Influenza, Human
Middle Aged
RNA, Viral
Seasons
Sentinel Surveillance
Sequence Analysis, DNA
Sex Distribution
Vaccination
Young Adult
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spelling Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14Broberg, Eeva KHungnes, OlavSchweiger, BrunhildeProsenc, KatarinaDaniels, RodGuiomar, RaquelIkonen, NiinaKossyvakis, AthanasiosPozo Sanchez, FranciscoPuzelli, SimonaThomas, IsabelleWaters, AllisonWiman, ÅsaMeijer, AdamAdolescentAdultAge DistributionAgedChildChild, PreschoolEpidemiological MonitoringEuropeEuropean UnionFeasibility StudiesHemagglutination Inhibition TestsHumansInfluenza A Virus, H1N1 SubtypeHospitalizationInfluenza A Virus, H3N2 SubtypeInfluenza VaccinesInfluenza, HumanMiddle AgedRNA, ViralSeasonsSentinel SurveillanceSequence Analysis, DNASex DistributionVaccinationYoung AdultInfluenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years) < 1 (65%; p = 0.0111), 20-39 (50%; p = 0.0046) and 40-64 (55%; p = 0.00001) while A(H3N2) viruses were most prevalent in those ≥ 65 years (62%*; p = 0.0012). Hospitalised patients in the age groups 6-19 years (67%; p = 0.0494) and ≥ 65 years (52%; p = 0.0005) were more frequently infected by A/Texas/50/2012 A(H3N2)-like viruses compared with hospitalised cases in other age groups. Strain-based reporting enabled deeper understanding of influenza virus circulation among hospitalised patients and substantially improved the reporting of virus characterisation data. Therefore, strain-based reporting of readily available data is recommended to all reporting countries within the EU/EEA.20182018-11-2020162016-10-1320162016-10-13research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6645reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución- 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/66452026-06-12T12:43:37Z
dc.title.none.fl_str_mv Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
spellingShingle Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
Broberg, Eeva K
Adolescent
Adult
Age Distribution
Aged
Child
Child, Preschool
Epidemiological Monitoring
Europe
European Union
Feasibility Studies
Hemagglutination Inhibition Tests
Humans
Influenza A Virus, H1N1 Subtype
Hospitalization
Influenza A Virus, H3N2 Subtype
Influenza Vaccines
Influenza, Human
Middle Aged
RNA, Viral
Seasons
Sentinel Surveillance
Sequence Analysis, DNA
Sex Distribution
Vaccination
Young Adult
title_short Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_full Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_fullStr Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_full_unstemmed Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
title_sort Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14
dc.creator.none.fl_str_mv Broberg, Eeva K
Hungnes, Olav
Schweiger, Brunhilde
Prosenc, Katarina
Daniels, Rod
Guiomar, Raquel
Ikonen, Niina
Kossyvakis, Athanasios
Pozo Sanchez, Francisco
Puzelli, Simona
Thomas, Isabelle
Waters, Allison
Wiman, Åsa
Meijer, Adam
author Broberg, Eeva K
author_facet Broberg, Eeva K
Hungnes, Olav
Schweiger, Brunhilde
Prosenc, Katarina
Daniels, Rod
Guiomar, Raquel
Ikonen, Niina
Kossyvakis, Athanasios
Pozo Sanchez, Francisco
Puzelli, Simona
Thomas, Isabelle
Waters, Allison
Wiman, Åsa
Meijer, Adam
author_role author
author2 Hungnes, Olav
Schweiger, Brunhilde
Prosenc, Katarina
Daniels, Rod
Guiomar, Raquel
Ikonen, Niina
Kossyvakis, Athanasios
Pozo Sanchez, Francisco
Puzelli, Simona
Thomas, Isabelle
Waters, Allison
Wiman, Åsa
Meijer, Adam
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Adolescent
Adult
Age Distribution
Aged
Child
Child, Preschool
Epidemiological Monitoring
Europe
European Union
Feasibility Studies
Hemagglutination Inhibition Tests
Humans
Influenza A Virus, H1N1 Subtype
Hospitalization
Influenza A Virus, H3N2 Subtype
Influenza Vaccines
Influenza, Human
Middle Aged
RNA, Viral
Seasons
Sentinel Surveillance
Sequence Analysis, DNA
Sex Distribution
Vaccination
Young Adult
topic Adolescent
Adult
Age Distribution
Aged
Child
Child, Preschool
Epidemiological Monitoring
Europe
European Union
Feasibility Studies
Hemagglutination Inhibition Tests
Humans
Influenza A Virus, H1N1 Subtype
Hospitalization
Influenza A Virus, H3N2 Subtype
Influenza Vaccines
Influenza, Human
Middle Aged
RNA, Viral
Seasons
Sentinel Surveillance
Sequence Analysis, DNA
Sex Distribution
Vaccination
Young Adult
description Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years) < 1 (65%; p = 0.0111), 20-39 (50%; p = 0.0046) and 40-64 (55%; p = 0.00001) while A(H3N2) viruses were most prevalent in those ≥ 65 years (62%*; p = 0.0012). Hospitalised patients in the age groups 6-19 years (67%; p = 0.0494) and ≥ 65 years (52%; p = 0.0005) were more frequently infected by A/Texas/50/2012 A(H3N2)-like viruses compared with hospitalised cases in other age groups. Strain-based reporting enabled deeper understanding of influenza virus circulation among hospitalised patients and substantially improved the reporting of virus characterisation data. Therefore, strain-based reporting of readily available data is recommended to all reporting countries within the EU/EEA.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-10-13
2016
2016-10-13
2018
2018-11-20
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6645
url http://hdl.handle.net/20.500.12105/6645
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución- 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución- 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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