Clinical implementation of 3D printing for the preparation of personalized medicines

This Thesis aims to contribute to the clinical implementation of 3D printing procedures for the preparation of personalized medicines in a hospital setting. Semisolid extrusion and volumetric 3D printing strategies were developed. Printlets were designed for pharmacological and dietary treatments of...

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Detalles Bibliográficos
Autor: Rodríguez Pombo, Lucía
Tipo de recurso: tesis doctoral
Fecha de publicación:2024
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/34499
Acceso en línea:http://hdl.handle.net/10347/34499
Access Level:acceso abierto
Palabra clave:320908 Preparación de medicamentos
320903 Evaluación de medicamentos
320902 Composición de medicamentos
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spelling Clinical implementation of 3D printing for the preparation of personalized medicinesRodríguez Pombo, Lucía320908 Preparación de medicamentos320903 Evaluación de medicamentos320902 Composición de medicamentosThis Thesis aims to contribute to the clinical implementation of 3D printing procedures for the preparation of personalized medicines in a hospital setting. Semisolid extrusion and volumetric 3D printing strategies were developed. Printlets were designed for pharmacological and dietary treatments of pediatric patients diagnosed with rare diseases and also for any person with characteristics (sex or physiopathological) that require dose customization. In this Thesis, volumetric 3D printing was upgraded, for first time, for the simultaneous manufacturing of oral dosage forms of different geometries. Additionally, quality assurance was addressed by designing a 3D printer with an integrated analytical balance for in-line quality control of printlets, ensuring that the printed medicines meet mass uniformity specifications.Álvarez Lorenzo, CarmenGoyanes Goyanes, ÁlvaroUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20242024-01-0120242024-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/34499reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/344992026-06-15T12:47:27Z
dc.title.none.fl_str_mv Clinical implementation of 3D printing for the preparation of personalized medicines
title Clinical implementation of 3D printing for the preparation of personalized medicines
spellingShingle Clinical implementation of 3D printing for the preparation of personalized medicines
Rodríguez Pombo, Lucía
320908 Preparación de medicamentos
320903 Evaluación de medicamentos
320902 Composición de medicamentos
title_short Clinical implementation of 3D printing for the preparation of personalized medicines
title_full Clinical implementation of 3D printing for the preparation of personalized medicines
title_fullStr Clinical implementation of 3D printing for the preparation of personalized medicines
title_full_unstemmed Clinical implementation of 3D printing for the preparation of personalized medicines
title_sort Clinical implementation of 3D printing for the preparation of personalized medicines
dc.creator.none.fl_str_mv Rodríguez Pombo, Lucía
author Rodríguez Pombo, Lucía
author_facet Rodríguez Pombo, Lucía
author_role author
dc.contributor.none.fl_str_mv Álvarez Lorenzo, Carmen
Goyanes Goyanes, Álvaro
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv 320908 Preparación de medicamentos
320903 Evaluación de medicamentos
320902 Composición de medicamentos
topic 320908 Preparación de medicamentos
320903 Evaluación de medicamentos
320902 Composición de medicamentos
description This Thesis aims to contribute to the clinical implementation of 3D printing procedures for the preparation of personalized medicines in a hospital setting. Semisolid extrusion and volumetric 3D printing strategies were developed. Printlets were designed for pharmacological and dietary treatments of pediatric patients diagnosed with rare diseases and also for any person with characteristics (sex or physiopathological) that require dose customization. In this Thesis, volumetric 3D printing was upgraded, for first time, for the simultaneous manufacturing of oral dosage forms of different geometries. Additionally, quality assurance was addressed by designing a 3D printer with an integrated analytical balance for in-line quality control of printlets, ensuring that the printed medicines meet mass uniformity specifications.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/34499
url http://hdl.handle.net/10347/34499
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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repository.mail.fl_str_mv
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