Clinical implementation of 3D printing for the preparation of personalized medicines
This Thesis aims to contribute to the clinical implementation of 3D printing procedures for the preparation of personalized medicines in a hospital setting. Semisolid extrusion and volumetric 3D printing strategies were developed. Printlets were designed for pharmacological and dietary treatments of...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/34499 |
| Acceso en línea: | http://hdl.handle.net/10347/34499 |
| Access Level: | acceso abierto |
| Palabra clave: | 320908 Preparación de medicamentos 320903 Evaluación de medicamentos 320902 Composición de medicamentos |
| Sumario: | This Thesis aims to contribute to the clinical implementation of 3D printing procedures for the preparation of personalized medicines in a hospital setting. Semisolid extrusion and volumetric 3D printing strategies were developed. Printlets were designed for pharmacological and dietary treatments of pediatric patients diagnosed with rare diseases and also for any person with characteristics (sex or physiopathological) that require dose customization. In this Thesis, volumetric 3D printing was upgraded, for first time, for the simultaneous manufacturing of oral dosage forms of different geometries. Additionally, quality assurance was addressed by designing a 3D printer with an integrated analytical balance for in-line quality control of printlets, ensuring that the printed medicines meet mass uniformity specifications. |
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