Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells

The role of the complement system during the innate immune response is well known. Nonetheless, complement acts also indirectly at the interface between innate and adaptive immunity. In addition, a solid body of evidence supports the relevance of its direct involvement in adaptive immune responses....

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Detalles Bibliográficos
Autor: Chacón Arguedas, Carlos Daniel
Tipo de recurso: tesis doctoral
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/129422
Acceso en línea:https://hdl.handle.net/20.500.14352/129422
Access Level:acceso abierto
Palabra clave:577.2(043.2)
Biología molecular
Molecular biology
Biología molecular (Biología)
2302.21 Biología Molecular
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spelling Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT CellsExplorando la interacción entre la señalización del TCR y su regulación por el Complemento en linfocitos TαβChacón Arguedas, Carlos Daniel577.2(043.2)Biología molecularMolecular biologyBiología molecular (Biología)2302.21 Biología MolecularThe role of the complement system during the innate immune response is well known. Nonetheless, complement acts also indirectly at the interface between innate and adaptive immunity. In addition, a solid body of evidence supports the relevance of its direct involvement in adaptive immune responses. For instance, the B cell antigen receptor (BCR) and surface complement receptors (CR) such as CR2 (CD21) crosstalk when engaged by C3b-opsonized antigens, leading in humans to an inhibitory effect on BCR activation and thus weaker antibody responses. Indeed, C3 deficiency impairs B cell differentiation to memory cells.T cells also integrate signals from various sources to regulate immune responses, including for instance those received through the TCR and CD28. Giving the relevant role of CR in B cells, many reports support that membrane CR and complement regulators (Creg) are important rheostats of T cell activation. However, the interaction between T cell and complement in humans is just beginning to be explored. The aim of this work was to study the expression and signaling of CR and Creg in primary αβ T lymphocytes and T cell lines before and after stimulation via TCR, as well as the effect of C3 on TCR-mediated activation and differentiation...Universidad Complutense de MadridTortajada Alonso, AgustínRegueiro Gonzales-Barros, José RamónUniversidad Complutense de Madrid20252025-12-1920252025-12-19doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/129422reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1294222026-06-02T12:44:21Z
dc.title.none.fl_str_mv Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
Explorando la interacción entre la señalización del TCR y su regulación por el Complemento en linfocitos Tαβ
title Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
spellingShingle Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
Chacón Arguedas, Carlos Daniel
577.2(043.2)
Biología molecular
Molecular biology
Biología molecular (Biología)
2302.21 Biología Molecular
title_short Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
title_full Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
title_fullStr Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
title_full_unstemmed Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
title_sort Exploring the Interplay Between TCR Signaling and its Regulation by Complement in αβT Cells
dc.creator.none.fl_str_mv Chacón Arguedas, Carlos Daniel
author Chacón Arguedas, Carlos Daniel
author_facet Chacón Arguedas, Carlos Daniel
author_role author
dc.contributor.none.fl_str_mv Tortajada Alonso, Agustín
Regueiro Gonzales-Barros, José Ramón
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.2(043.2)
Biología molecular
Molecular biology
Biología molecular (Biología)
2302.21 Biología Molecular
topic 577.2(043.2)
Biología molecular
Molecular biology
Biología molecular (Biología)
2302.21 Biología Molecular
description The role of the complement system during the innate immune response is well known. Nonetheless, complement acts also indirectly at the interface between innate and adaptive immunity. In addition, a solid body of evidence supports the relevance of its direct involvement in adaptive immune responses. For instance, the B cell antigen receptor (BCR) and surface complement receptors (CR) such as CR2 (CD21) crosstalk when engaged by C3b-opsonized antigens, leading in humans to an inhibitory effect on BCR activation and thus weaker antibody responses. Indeed, C3 deficiency impairs B cell differentiation to memory cells.T cells also integrate signals from various sources to regulate immune responses, including for instance those received through the TCR and CD28. Giving the relevant role of CR in B cells, many reports support that membrane CR and complement regulators (Creg) are important rheostats of T cell activation. However, the interaction between T cell and complement in humans is just beginning to be explored. The aim of this work was to study the expression and signaling of CR and Creg in primary αβ T lymphocytes and T cell lines before and after stimulation via TCR, as well as the effect of C3 on TCR-mediated activation and differentiation...
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-12-19
2025
2025-12-19
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/129422
url https://hdl.handle.net/20.500.14352/129422
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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