Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p4567 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4567 https://ddd.uab.cat/record/271912 |
| Access Level: | acceso abierto |
| Palabra clave: | mood non-motor symptoms Parkinson's disease progression quality of life |
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Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-UpDiego, SGTeresa, DDCores, CCanfield, HPaz Gonzalez, JMMiro, CMAymerich, LVSuarez, EJesus, SAguilar, MPastor, PPlanellas, LCosgaya, MCaldentey, JGCaballol, NLegarda, IHernandez-Vara, JCabo, IManzanares, LLAramburu, IGAvila Rivera, MACatalan, MJNogueira, VPuente, VDotor, JBorrue, CSolano, BAlvarez Sauco, MVela, LEscalante, SCubo, ECarrillo, FMartinez Castrillo, JCAlonso, PSAlonso, GAriztegui, NLGaston, IKulisevsky, JBlazquez, MSeijo, MRuiz Martinez, JValero, CKurtis, Mde Fabregues, OArdura, JAlonso, ROrdas, CDiaz, LMLMcAfee, DMartinez-Martin, PMir, PCOPPADIS Study Groupmoodnon-motor symptomsParkinson's diseaseprogressionquality of lifeBackground and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months +/- 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 +/- 37.62 to 53.55 +/- 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 +/- 8.91) compared to no change observed in controls (from 14.74 +/- 18.72 to 14.65 +/- 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 +/- 8.32) (p < 0.0001). NMSS total score at baseline (beta = -0.52), change from V0 to V2 in PDSS (Parkinson's Disease Sleep Scale) (beta = -0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (beta = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4567https://ddd.uab.cat/record/271912Journal of Personalized MedicineISSN: 20754426reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p45672026-06-14T12:41:47Z |
| dc.title.none.fl_str_mv |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| spellingShingle |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up Diego, SG mood non-motor symptoms Parkinson's disease progression quality of life |
| title_short |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_full |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_fullStr |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_full_unstemmed |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| title_sort |
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up |
| dc.creator.none.fl_str_mv |
Diego, SG Teresa, DD Cores, C Canfield, H Paz Gonzalez, JM Miro, CM Aymerich, LV Suarez, E Jesus, S Aguilar, M Pastor, P Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Hernandez-Vara, J Cabo, I Manzanares, LL Aramburu, IG Avila Rivera, MA Catalan, MJ Nogueira, V Puente, V Dotor, J Borrue, C Solano, B Alvarez Sauco, M Vela, L Escalante, S Cubo, E Carrillo, F Martinez Castrillo, JC Alonso, PS Alonso, G Ariztegui, NL Gaston, I Kulisevsky, J Blazquez, M Seijo, M Ruiz Martinez, J Valero, C Kurtis, M de Fabregues, O Ardura, J Alonso, R Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P COPPADIS Study Group |
| author |
Diego, SG |
| author_facet |
Diego, SG Teresa, DD Cores, C Canfield, H Paz Gonzalez, JM Miro, CM Aymerich, LV Suarez, E Jesus, S Aguilar, M Pastor, P Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Hernandez-Vara, J Cabo, I Manzanares, LL Aramburu, IG Avila Rivera, MA Catalan, MJ Nogueira, V Puente, V Dotor, J Borrue, C Solano, B Alvarez Sauco, M Vela, L Escalante, S Cubo, E Carrillo, F Martinez Castrillo, JC Alonso, PS Alonso, G Ariztegui, NL Gaston, I Kulisevsky, J Blazquez, M Seijo, M Ruiz Martinez, J Valero, C Kurtis, M de Fabregues, O Ardura, J Alonso, R Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P COPPADIS Study Group |
| author_role |
author |
| author2 |
Teresa, DD Cores, C Canfield, H Paz Gonzalez, JM Miro, CM Aymerich, LV Suarez, E Jesus, S Aguilar, M Pastor, P Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Hernandez-Vara, J Cabo, I Manzanares, LL Aramburu, IG Avila Rivera, MA Catalan, MJ Nogueira, V Puente, V Dotor, J Borrue, C Solano, B Alvarez Sauco, M Vela, L Escalante, S Cubo, E Carrillo, F Martinez Castrillo, JC Alonso, PS Alonso, G Ariztegui, NL Gaston, I Kulisevsky, J Blazquez, M Seijo, M Ruiz Martinez, J Valero, C Kurtis, M de Fabregues, O Ardura, J Alonso, R Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P COPPADIS Study Group |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
mood non-motor symptoms Parkinson's disease progression quality of life |
| topic |
mood non-motor symptoms Parkinson's disease progression quality of life |
| description |
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months +/- 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 +/- 37.62 to 53.55 +/- 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 +/- 8.91) compared to no change observed in controls (from 14.74 +/- 18.72 to 14.65 +/- 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 +/- 8.32) (p < 0.0001). NMSS total score at baseline (beta = -0.52), change from V0 to V2 in PDSS (Parkinson's Disease Sleep Scale) (beta = -0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (beta = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4567 https://ddd.uab.cat/record/271912 |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4567 https://ddd.uab.cat/record/271912 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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Journal of Personalized Medicine ISSN: 20754426 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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