Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up

Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and...

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Detalhes bibliográficos
Autores: Santos-García, Diego, Teresa, De Deus, Cores Bartolomé, Carlos, Canfield, Hector, Paz Gonzalez, Jose M., Martinez Miro, Cristina, Valdes Aymerich, Lorena, Suarez, Ester, Jesus, Silvia, Aguilar, Miquel, Pastor, Pau, Planellas, Lluis, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria, Legarda Ramírez, Inés, Hernández Vara, Jorge, Cabo-Lopez, Iria, Lopez Manzanares, Lydia, Gonzalez Aramburu, Isabel, Ávila Rivera, Maria A, Catalan, Maria Jose, Nogueira, Victor, Puente, Victor, Dotor, Julio, Borrué, Carmen, Solano, Berta, Alvarez Sauco, Maria, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martinez Castrillo, Juan C., Sánchez Alonso, Pilar, Alonso, Gemma, López Ariztegui, Nuria, Gaston, Itziar, Kulisevsky, Jaime, Blazquez, Marta, Seijo, Manuel, Ruiz Martinez, Javier, Valero, Caridad, Kurtis, Monica, de Fabregues-Boixar, Oriol, Ardura, Jessica, Alonso, Ruben, Ordas, Carlos, Lopez Diaz, Luis M., McAfee, Darrian, Martinez-Martin, Pablo, Mir, Pablo, COPPADIS Study Group
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19761
Acesso em linha:https://hdl.handle.net/20.500.13003/19761
Access Level:acceso abierto
Palavra-chave:mood
non-motor symptoms
Parkinson's disease
progression
quality of life
Descrição
Resumo:Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months +/- 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 +/- 37.62 to 53.55 +/- 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 +/- 8.91) compared to no change observed in controls (from 14.74 +/- 18.72 to 14.65 +/- 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 +/- 8.32) (p < 0.0001). NMSS total score at baseline (beta = -0.52), change from V0 to V2 in PDSS (Parkinson's Disease Sleep Scale) (beta = -0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (beta = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.

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