Regional brain morphology and current antidepressant use
The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology in relation to age and sex by pooling structural neuroimaging...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:uabarcelona_::38ce5e377212c442db72111be807db4f |
| Acceso en línea: | https://ddd.uab.cat/record/328193 https://dx.doi.org/urn:doi:10.1038/s41380-025-03310-8 |
| Access Level: | acceso abierto |
| Palabra clave: | Depression Neuroscience |
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| dc.title.none.fl_str_mv |
Regional brain morphology and current antidepressant use findings from 32 international cohorts from the ENIGMA major depressive disorder working group |
| title |
Regional brain morphology and current antidepressant use |
| spellingShingle |
Regional brain morphology and current antidepressant use Toenders, Yara J.|||0000-0002-4117-1143 Depression Neuroscience |
| title_short |
Regional brain morphology and current antidepressant use |
| title_full |
Regional brain morphology and current antidepressant use |
| title_fullStr |
Regional brain morphology and current antidepressant use |
| title_full_unstemmed |
Regional brain morphology and current antidepressant use |
| title_sort |
Regional brain morphology and current antidepressant use |
| dc.creator.none.fl_str_mv |
Toenders, Yara J.|||0000-0002-4117-1143 Pozzi, Elena|||0000-0001-8360-5571 Aleman, André|||0000-0001-5372-0886 Başgöze, Zeynep|||0000-0002-0306-4849 Berger, Klaus Brosch, Katharina|||0000-0002-0526-8095 Bülow, Robin|||0000-0003-1884-5784 Filho, Geraldo Busatto|||0000-0003-4749-4602 Capitão, Liliana|||0000-0003-3117-5156 Connolly, Colm G.|||0000-0002-4051-3682 Couvy-Duchesne, Baptiste|||0000-0002-0719-9302 Cullen, Kathryn R. Dannlowski, Udo|||0000-0002-0623-3759 Davey, Christopher|||0000-0003-1431-3852 de Zubicaray, Greig|||0000-0003-4506-0579 Dima, Danai|||0000-0002-2598-0952 Dohm, Katharina Enneking, Verena|||0000-0002-6547-0324 Erwin-Grabner, Tracy Evermann, Ulrika|||0000-0002-3250-7821 Fu, Cynthia H.Y.|||0000-0003-4313-3500 Fuentes-Claramonte, Paola|||0000-0002-1428-7976 Godlewska, Beata|||0000-0002-5973-3765 Gotlib, Ian H.|||0000-0002-3622-3199 Goya-Maldonado, Roberto Grabe, Hans J.|||0000-0003-3684-4208 Groenewold, Nynke A.|||0000-0002-0865-8427 Grotegerd, Dominik Gruber, Oliver Hahn, Tim|||0000-0002-8929-4134 Harrison, Ben J. Hermesdorf, Marco|||0000-0003-3541-7212 Ho, Tiffany C. Jahanshad, Neda|||0000-0003-4401-8950 Jamalabadi, Hamidreza|||0000-0003-2485-2374 Jamieson, Alec|||0000-0002-5598-0240 Jansen, Andreas Kircher, Tilo|||0000-0002-2514-2625 Klimes-Dougan, Bonnie|||0000-0002-2107-0038 Krämer, Bernd|||0000-0002-1145-9103 Krug, Axel|||0000-0002-0564-2497 Leehr, Elisabeth J.|||0000-0002-9264-5003 Li, Meng Linden, David E. J.|||0000-0002-5638-9292 MacMaster, Frank|||0000-0002-7159-7583 McMahon, Katie|||0000-0002-6357-615X Medland, Sarah Elizabeth|||0000-0003-1382-380X Mehler, David M. A. Meinert, Susanne|||0000-0003-2177-7161 Mwangi, Benson|||0000-0002-1717-4395 Nenadić, Igor|||0000-0002-0749-7473 Opel, Nils Pomarol-Clotet, Edith|||0000-0002-8159-8563 Portella Moll, Maria J., 1975-|||0000-0002-2007-9516 Redlich, Ronny Reneman, Liesbeth|||0000-0002-5912-9971 Repple, Jonathan|||0000-0003-1379-9491 Rodriguez-Cano, Elena Rosa, Pedro G. P. Sacchet, Matthew D. Sämann, Philipp G. Salvador, Raymond|||0000-0001-5557-1562 Schrantee, Anouk|||0000-0002-4035-4845 Shinzato, Hotaka|||0000-0002-0354-1801 Sim, Kang|||0000-0003-3209-9626 Simulionyte, Egle Soares, Jair C.|||0000-0002-5466-5628 Stein, Dan J.|||0000-0001-7218-7810 Stein, Frederike|||0000-0002-5052-6022 Straube, Benjamin|||0000-0002-9837-0944 Strike, Lachlan|||0000-0003-2885-5898 Thomopoulos, Sophia I.|||0000-0002-0046-4070 Thompson, Paul M.|||0000-0002-4720-8867 van Tol, Marie-José|||0000-0002-9260-5490 Uyar, Aslihan|||0000-0002-0856-4260 Vives-Gilabert, Yolanda|||0000-0002-3744-5893 Völzke, Henry|||0000-0001-7003-399X Walter, Martin Whittle, Sarah Wittfeld, Katharina|||0000-0003-4383-5043 Wroblewski, Adrian|||0000-0002-0371-7686 Wu, Mon-Ju|||0000-0002-0540-8027 Yang, Tony T. Zunta-Soares, Giovana B. Veltman, Dick J. Schmaal, Lianne|||0000-0001-9822-048X van Velzen, Laura S. Serrarens, Chaira Alexander, Nina Belov, Vladimir Gonul, Ali Saffet Hall, Geoffrey B. Heindel, Walter Ichikawa, Naho Itai, Eri Lancaster, Thomas M. Okada, Go Okamoto, Yasumasa Pfarr, Julia-Katharina Ringwald, Kai Thomas-Odenthal, Florian Usemann, Paula Van der Wee, Nic J. A. van der Werff, Steven J. A. |
| author |
Toenders, Yara J.|||0000-0002-4117-1143 |
| author_facet |
Toenders, Yara J.|||0000-0002-4117-1143 Pozzi, Elena|||0000-0001-8360-5571 Aleman, André|||0000-0001-5372-0886 Başgöze, Zeynep|||0000-0002-0306-4849 Berger, Klaus Brosch, Katharina|||0000-0002-0526-8095 Bülow, Robin|||0000-0003-1884-5784 Filho, Geraldo Busatto|||0000-0003-4749-4602 Capitão, Liliana|||0000-0003-3117-5156 Connolly, Colm G.|||0000-0002-4051-3682 Couvy-Duchesne, Baptiste|||0000-0002-0719-9302 Cullen, Kathryn R. Dannlowski, Udo|||0000-0002-0623-3759 Davey, Christopher|||0000-0003-1431-3852 de Zubicaray, Greig|||0000-0003-4506-0579 Dima, Danai|||0000-0002-2598-0952 Dohm, Katharina Enneking, Verena|||0000-0002-6547-0324 Erwin-Grabner, Tracy Evermann, Ulrika|||0000-0002-3250-7821 Fu, Cynthia H.Y.|||0000-0003-4313-3500 Fuentes-Claramonte, Paola|||0000-0002-1428-7976 Godlewska, Beata|||0000-0002-5973-3765 Gotlib, Ian H.|||0000-0002-3622-3199 Goya-Maldonado, Roberto Grabe, Hans J.|||0000-0003-3684-4208 Groenewold, Nynke A.|||0000-0002-0865-8427 Grotegerd, Dominik Gruber, Oliver Hahn, Tim|||0000-0002-8929-4134 Harrison, Ben J. Hermesdorf, Marco|||0000-0003-3541-7212 Ho, Tiffany C. Jahanshad, Neda|||0000-0003-4401-8950 Jamalabadi, Hamidreza|||0000-0003-2485-2374 Jamieson, Alec|||0000-0002-5598-0240 Jansen, Andreas Kircher, Tilo|||0000-0002-2514-2625 Klimes-Dougan, Bonnie|||0000-0002-2107-0038 Krämer, Bernd|||0000-0002-1145-9103 Krug, Axel|||0000-0002-0564-2497 Leehr, Elisabeth J.|||0000-0002-9264-5003 Li, Meng Linden, David E. J.|||0000-0002-5638-9292 MacMaster, Frank|||0000-0002-7159-7583 McMahon, Katie|||0000-0002-6357-615X Medland, Sarah Elizabeth|||0000-0003-1382-380X Mehler, David M. A. Meinert, Susanne|||0000-0003-2177-7161 Mwangi, Benson|||0000-0002-1717-4395 Nenadić, Igor|||0000-0002-0749-7473 Opel, Nils Pomarol-Clotet, Edith|||0000-0002-8159-8563 Portella Moll, Maria J., 1975-|||0000-0002-2007-9516 Redlich, Ronny Reneman, Liesbeth|||0000-0002-5912-9971 Repple, Jonathan|||0000-0003-1379-9491 Rodriguez-Cano, Elena Rosa, Pedro G. P. Sacchet, Matthew D. Sämann, Philipp G. Salvador, Raymond|||0000-0001-5557-1562 Schrantee, Anouk|||0000-0002-4035-4845 Shinzato, Hotaka|||0000-0002-0354-1801 Sim, Kang|||0000-0003-3209-9626 Simulionyte, Egle Soares, Jair C.|||0000-0002-5466-5628 Stein, Dan J.|||0000-0001-7218-7810 Stein, Frederike|||0000-0002-5052-6022 Straube, Benjamin|||0000-0002-9837-0944 Strike, Lachlan|||0000-0003-2885-5898 Thomopoulos, Sophia I.|||0000-0002-0046-4070 Thompson, Paul M.|||0000-0002-4720-8867 van Tol, Marie-José|||0000-0002-9260-5490 Uyar, Aslihan|||0000-0002-0856-4260 Vives-Gilabert, Yolanda|||0000-0002-3744-5893 Völzke, Henry|||0000-0001-7003-399X Walter, Martin Whittle, Sarah Wittfeld, Katharina|||0000-0003-4383-5043 Wroblewski, Adrian|||0000-0002-0371-7686 Wu, Mon-Ju|||0000-0002-0540-8027 Yang, Tony T. Zunta-Soares, Giovana B. Veltman, Dick J. Schmaal, Lianne|||0000-0001-9822-048X van Velzen, Laura S. Serrarens, Chaira Alexander, Nina Belov, Vladimir Gonul, Ali Saffet Hall, Geoffrey B. Heindel, Walter Ichikawa, Naho Itai, Eri Lancaster, Thomas M. Okada, Go Okamoto, Yasumasa Pfarr, Julia-Katharina Ringwald, Kai Thomas-Odenthal, Florian Usemann, Paula Van der Wee, Nic J. A. van der Werff, Steven J. A. |
| author_role |
author |
| author2 |
Pozzi, Elena|||0000-0001-8360-5571 Aleman, André|||0000-0001-5372-0886 Başgöze, Zeynep|||0000-0002-0306-4849 Berger, Klaus Brosch, Katharina|||0000-0002-0526-8095 Bülow, Robin|||0000-0003-1884-5784 Filho, Geraldo Busatto|||0000-0003-4749-4602 Capitão, Liliana|||0000-0003-3117-5156 Connolly, Colm G.|||0000-0002-4051-3682 Couvy-Duchesne, Baptiste|||0000-0002-0719-9302 Cullen, Kathryn R. Dannlowski, Udo|||0000-0002-0623-3759 Davey, Christopher|||0000-0003-1431-3852 de Zubicaray, Greig|||0000-0003-4506-0579 Dima, Danai|||0000-0002-2598-0952 Dohm, Katharina Enneking, Verena|||0000-0002-6547-0324 Erwin-Grabner, Tracy Evermann, Ulrika|||0000-0002-3250-7821 Fu, Cynthia H.Y.|||0000-0003-4313-3500 Fuentes-Claramonte, Paola|||0000-0002-1428-7976 Godlewska, Beata|||0000-0002-5973-3765 Gotlib, Ian H.|||0000-0002-3622-3199 Goya-Maldonado, Roberto Grabe, Hans J.|||0000-0003-3684-4208 Groenewold, Nynke A.|||0000-0002-0865-8427 Grotegerd, Dominik Gruber, Oliver Hahn, Tim|||0000-0002-8929-4134 Harrison, Ben J. Hermesdorf, Marco|||0000-0003-3541-7212 Ho, Tiffany C. Jahanshad, Neda|||0000-0003-4401-8950 Jamalabadi, Hamidreza|||0000-0003-2485-2374 Jamieson, Alec|||0000-0002-5598-0240 Jansen, Andreas Kircher, Tilo|||0000-0002-2514-2625 Klimes-Dougan, Bonnie|||0000-0002-2107-0038 Krämer, Bernd|||0000-0002-1145-9103 Krug, Axel|||0000-0002-0564-2497 Leehr, Elisabeth J.|||0000-0002-9264-5003 Li, Meng Linden, David E. J.|||0000-0002-5638-9292 MacMaster, Frank|||0000-0002-7159-7583 McMahon, Katie|||0000-0002-6357-615X Medland, Sarah Elizabeth|||0000-0003-1382-380X Mehler, David M. A. Meinert, Susanne|||0000-0003-2177-7161 Mwangi, Benson|||0000-0002-1717-4395 Nenadić, Igor|||0000-0002-0749-7473 Opel, Nils Pomarol-Clotet, Edith|||0000-0002-8159-8563 Portella Moll, Maria J., 1975-|||0000-0002-2007-9516 Redlich, Ronny Reneman, Liesbeth|||0000-0002-5912-9971 Repple, Jonathan|||0000-0003-1379-9491 Rodriguez-Cano, Elena Rosa, Pedro G. P. Sacchet, Matthew D. Sämann, Philipp G. Salvador, Raymond|||0000-0001-5557-1562 Schrantee, Anouk|||0000-0002-4035-4845 Shinzato, Hotaka|||0000-0002-0354-1801 Sim, Kang|||0000-0003-3209-9626 Simulionyte, Egle Soares, Jair C.|||0000-0002-5466-5628 Stein, Dan J.|||0000-0001-7218-7810 Stein, Frederike|||0000-0002-5052-6022 Straube, Benjamin|||0000-0002-9837-0944 Strike, Lachlan|||0000-0003-2885-5898 Thomopoulos, Sophia I.|||0000-0002-0046-4070 Thompson, Paul M.|||0000-0002-4720-8867 van Tol, Marie-José|||0000-0002-9260-5490 Uyar, Aslihan|||0000-0002-0856-4260 Vives-Gilabert, Yolanda|||0000-0002-3744-5893 Völzke, Henry|||0000-0001-7003-399X Walter, Martin Whittle, Sarah Wittfeld, Katharina|||0000-0003-4383-5043 Wroblewski, Adrian|||0000-0002-0371-7686 Wu, Mon-Ju|||0000-0002-0540-8027 Yang, Tony T. Zunta-Soares, Giovana B. Veltman, Dick J. Schmaal, Lianne|||0000-0001-9822-048X van Velzen, Laura S. Serrarens, Chaira Alexander, Nina Belov, Vladimir Gonul, Ali Saffet Hall, Geoffrey B. Heindel, Walter Ichikawa, Naho Itai, Eri Lancaster, Thomas M. Okada, Go Okamoto, Yasumasa Pfarr, Julia-Katharina Ringwald, Kai Thomas-Odenthal, Florian Usemann, Paula Van der Wee, Nic J. A. van der Werff, Steven J. A. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
Depression Neuroscience |
| topic |
Depression Neuroscience |
| description |
The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology in relation to age and sex by pooling structural neuroimaging and clinical data from 32 cohorts within the ENIGMA-MDD working group. Interaction effects of group (2076 cases with current AD use (AD), 1495 cases not currently taking AD (nAD) and 5125 healthy controls (HC)) with age and sex, and main effects of group on regional brain structure (cortical surface area and thickness, and subcortical volume) were examined. Additionally, we examined the effect of AD type (SSRI, SNRI or mirtazapine) and duration of use on brain morphology. Younger individuals in the AD group showed lower bilateral middle temporal gyrus thickness compared to nAD and HC, but this was not seen in older individuals (crossover around 50 years). Lower hippocampal volume and thinner inferior temporal gyrus were shown in AD compared to nAD. These effects were independent of group differences in disease-course-related measures, but were driven by depressive symptom severity. Greater bilateral rostral anterior cingulate thickness was found in individuals older than approximately 40 years taking mirtazapine compared to individuals taking SSRIs or SNRIs. Evidence for subtle structural brain differences in temporal and limbic regions in individuals with MDD who currently use AD medication were found compared to those not currently taking AD medication. Future longitudinal studies are needed to determine the causality of these associations. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/328193 https://dx.doi.org/urn:doi:10.1038/s41380-025-03310-8 |
| url |
https://ddd.uab.cat/record/328193 https://dx.doi.org/urn:doi:10.1038/s41380-025-03310-8 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/01057 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
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| repository.mail.fl_str_mv |
|
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1869425438708727808 |
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Regional brain morphology and current antidepressant usefindings from 32 international cohorts from the ENIGMA major depressive disorder working groupToenders, Yara J.|||0000-0002-4117-1143Pozzi, Elena|||0000-0001-8360-5571Aleman, André|||0000-0001-5372-0886Başgöze, Zeynep|||0000-0002-0306-4849Berger, KlausBrosch, Katharina|||0000-0002-0526-8095Bülow, Robin|||0000-0003-1884-5784Filho, Geraldo Busatto|||0000-0003-4749-4602Capitão, Liliana|||0000-0003-3117-5156Connolly, Colm G.|||0000-0002-4051-3682Couvy-Duchesne, Baptiste|||0000-0002-0719-9302Cullen, Kathryn R.Dannlowski, Udo|||0000-0002-0623-3759Davey, Christopher|||0000-0003-1431-3852de Zubicaray, Greig|||0000-0003-4506-0579Dima, Danai|||0000-0002-2598-0952Dohm, KatharinaEnneking, Verena|||0000-0002-6547-0324Erwin-Grabner, TracyEvermann, Ulrika|||0000-0002-3250-7821Fu, Cynthia H.Y.|||0000-0003-4313-3500Fuentes-Claramonte, Paola|||0000-0002-1428-7976Godlewska, Beata|||0000-0002-5973-3765Gotlib, Ian H.|||0000-0002-3622-3199Goya-Maldonado, RobertoGrabe, Hans J.|||0000-0003-3684-4208Groenewold, Nynke A.|||0000-0002-0865-8427Grotegerd, DominikGruber, OliverHahn, Tim|||0000-0002-8929-4134Harrison, Ben J.Hermesdorf, Marco|||0000-0003-3541-7212Ho, Tiffany C.Jahanshad, Neda|||0000-0003-4401-8950Jamalabadi, Hamidreza|||0000-0003-2485-2374Jamieson, Alec|||0000-0002-5598-0240Jansen, AndreasKircher, Tilo|||0000-0002-2514-2625Klimes-Dougan, Bonnie|||0000-0002-2107-0038Krämer, Bernd|||0000-0002-1145-9103Krug, Axel|||0000-0002-0564-2497Leehr, Elisabeth J.|||0000-0002-9264-5003Li, MengLinden, David E. J.|||0000-0002-5638-9292MacMaster, Frank|||0000-0002-7159-7583McMahon, Katie|||0000-0002-6357-615XMedland, Sarah Elizabeth|||0000-0003-1382-380XMehler, David M. A.Meinert, Susanne|||0000-0003-2177-7161Mwangi, Benson|||0000-0002-1717-4395Nenadić, Igor|||0000-0002-0749-7473Opel, NilsPomarol-Clotet, Edith|||0000-0002-8159-8563Portella Moll, Maria J., 1975-|||0000-0002-2007-9516Redlich, RonnyReneman, Liesbeth|||0000-0002-5912-9971Repple, Jonathan|||0000-0003-1379-9491Rodriguez-Cano, ElenaRosa, Pedro G. P.Sacchet, Matthew D.Sämann, Philipp G.Salvador, Raymond|||0000-0001-5557-1562Schrantee, Anouk|||0000-0002-4035-4845Shinzato, Hotaka|||0000-0002-0354-1801Sim, Kang|||0000-0003-3209-9626Simulionyte, EgleSoares, Jair C.|||0000-0002-5466-5628Stein, Dan J.|||0000-0001-7218-7810Stein, Frederike|||0000-0002-5052-6022Straube, Benjamin|||0000-0002-9837-0944Strike, Lachlan|||0000-0003-2885-5898Thomopoulos, Sophia I.|||0000-0002-0046-4070Thompson, Paul M.|||0000-0002-4720-8867van Tol, Marie-José|||0000-0002-9260-5490Uyar, Aslihan|||0000-0002-0856-4260Vives-Gilabert, Yolanda|||0000-0002-3744-5893Völzke, Henry|||0000-0001-7003-399XWalter, MartinWhittle, SarahWittfeld, Katharina|||0000-0003-4383-5043Wroblewski, Adrian|||0000-0002-0371-7686Wu, Mon-Ju|||0000-0002-0540-8027Yang, Tony T.Zunta-Soares, Giovana B.Veltman, Dick J.Schmaal, Lianne|||0000-0001-9822-048Xvan Velzen, Laura S.Serrarens, ChairaAlexander, NinaBelov, VladimirGonul, Ali SaffetHall, Geoffrey B.Heindel, WalterIchikawa, NahoItai, EriLancaster, Thomas M.Okada, GoOkamoto, YasumasaPfarr, Julia-KatharinaRingwald, KaiThomas-Odenthal, FlorianUsemann, PaulaVan der Wee, Nic J. A.van der Werff, Steven J. A.DepressionNeuroscienceThe understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology in relation to age and sex by pooling structural neuroimaging and clinical data from 32 cohorts within the ENIGMA-MDD working group. Interaction effects of group (2076 cases with current AD use (AD), 1495 cases not currently taking AD (nAD) and 5125 healthy controls (HC)) with age and sex, and main effects of group on regional brain structure (cortical surface area and thickness, and subcortical volume) were examined. Additionally, we examined the effect of AD type (SSRI, SNRI or mirtazapine) and duration of use on brain morphology. Younger individuals in the AD group showed lower bilateral middle temporal gyrus thickness compared to nAD and HC, but this was not seen in older individuals (crossover around 50 years). Lower hippocampal volume and thinner inferior temporal gyrus were shown in AD compared to nAD. These effects were independent of group differences in disease-course-related measures, but were driven by depressive symptom severity. Greater bilateral rostral anterior cingulate thickness was found in individuals older than approximately 40 years taking mirtazapine compared to individuals taking SSRIs or SNRIs. Evidence for subtle structural brain differences in temporal and limbic regions in individuals with MDD who currently use AD medication were found compared to those not currently taking AD medication. Future longitudinal studies are needed to determine the causality of these associations.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/328193https://dx.doi.org/urn:doi:10.1038/s41380-025-03310-8reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/01057open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::38ce5e377212c442db72111be807db4f2026-06-06T12:50:31Z |
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15.812429 |