Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the e...

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Detalles Bibliográficos
Autores: Prats, Anna|||0000-0002-3586-4525, Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284, Mothe, Beatriz|||0000-0001-9975-407X, Negredo Puigmal, Eugènia|||0000-0001-5298-1734, Pérez-Álvarez, Núria|||0000-0001-6582-1553, Garolera, Maite, Domenech, Sira|||0000-0002-5700-768X, Coll, Pep, Meulbroek, Michael, Chamorro, Anna, Fumaz, Carmina R.|||0000-0003-0838-3395, Ferrer, Maria Jose, Clotet Sala, Bonaventura|||0000-0003-3232-4598, Soriano-Mas, Carles|||0000-0003-4574-6597, Muñoz-Moreno, José Antonio|||0000-0002-7239-5422
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255608
Acceso en línea:https://ddd.uab.cat/record/255608
https://dx.doi.org/urn:doi:10.1038/s41598-021-90678-6
Access Level:acceso abierto
Palabra clave:Infectious diseases
Cognitive neuroscience
Anxiety
Depression
Central nervous system infections
Descripción
Sumario:Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the effects of INSTI-based antiretroviral therapy on comprehensive brain outcomes (cognitive, functional, and imaging) according to the time since HIV-1 acquisition. We recruited men living with HIV who initiated antiretroviral therapy with INSTI < 3 months since the estimated date of HIV-1 acquisition (n = 12) and.

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