Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma
The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:282870 |
| Acceso en línea: | https://ddd.uab.cat/record/282870 https://dx.doi.org/urn:doi:10.3390/jcm10245878 |
| Access Level: | acceso abierto |
| Palabra clave: | Melanoma Sentinel lymph node biopsy Survival |
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Sentinel Lymph Node Biopsy vs. Observation in Thin MelanomaA Multicenter Propensity Score Matching StudyTejera-Vaquerizo, Antonio|||0000-0002-8987-0744Boada, Aram|||0000-0001-9809-5308Ribero, SimonePuig, Susana|||0000-0003-1337-9745Paradela, Sabela|||0000-0002-6779-6459Moreno-Ramírez, David|||0000-0002-1301-7974Cañueto, Javierde Unamuno-Bustos, BlancaBrinca, AnaDescalzo-Gallego, Miguel A.Osella-Abate, Simona|||0000-0002-9886-7694Cassoni, Paola|||0000-0003-1977-7410Podlipnik, Sebastian|||0000-0003-4150-0522Carrera, Cristina|||0000-0003-1608-8820Vidal-Sicart, Sergi|||0000-0002-6303-3606Pigem, Ramón|||0000-0002-3224-8241Toll Abelló, Agustí|||0000-0003-2656-0076Rull, Ramón|||0000-0002-8345-4598Alos, Llucìa|||0000-0002-3460-0384Requena, CeliaBolumar, IsidroTraves, VíctorPla, ÁngelFernández-Orland, AlmudenaJaka, Ane|||0000-0003-2699-1159Fernández-Figueras, Maria Teresa|||0000-0002-2366-7110Richarz, Nina Anika|||0000-0003-0027-8769Vieira, RicardoBotella-Estrada, RafaelRomán-Curto, Concepción|||0000-0001-6147-9412Ferrándiz-Pulido, LaraIglesias-Pena, Nicolás|||0000-0002-7282-5015Ferrándiz, Carlos|||0000-0001-9030-8399Malvehy, Josep|||0000-0002-6998-914XQuaglino, PietroNagore, Eduardo|||0000-0003-3433-8707MelanomaSentinel lymph node biopsySurvivalThe therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (p < 0.001) and 97.3% vs. 68.7% (p < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/282870https://dx.doi.org/urn:doi:10.3390/jcm10245878reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00956Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI12/00840Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00716Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00419open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2828702026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma A Multicenter Propensity Score Matching Study |
| title |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma |
| spellingShingle |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma Tejera-Vaquerizo, Antonio|||0000-0002-8987-0744 Melanoma Sentinel lymph node biopsy Survival |
| title_short |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma |
| title_full |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma |
| title_fullStr |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma |
| title_full_unstemmed |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma |
| title_sort |
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma |
| dc.creator.none.fl_str_mv |
Tejera-Vaquerizo, Antonio|||0000-0002-8987-0744 Boada, Aram|||0000-0001-9809-5308 Ribero, Simone Puig, Susana|||0000-0003-1337-9745 Paradela, Sabela|||0000-0002-6779-6459 Moreno-Ramírez, David|||0000-0002-1301-7974 Cañueto, Javier de Unamuno-Bustos, Blanca Brinca, Ana Descalzo-Gallego, Miguel A. Osella-Abate, Simona|||0000-0002-9886-7694 Cassoni, Paola|||0000-0003-1977-7410 Podlipnik, Sebastian|||0000-0003-4150-0522 Carrera, Cristina|||0000-0003-1608-8820 Vidal-Sicart, Sergi|||0000-0002-6303-3606 Pigem, Ramón|||0000-0002-3224-8241 Toll Abelló, Agustí|||0000-0003-2656-0076 Rull, Ramón|||0000-0002-8345-4598 Alos, Llucìa|||0000-0002-3460-0384 Requena, Celia Bolumar, Isidro Traves, Víctor Pla, Ángel Fernández-Orland, Almudena Jaka, Ane|||0000-0003-2699-1159 Fernández-Figueras, Maria Teresa|||0000-0002-2366-7110 Richarz, Nina Anika|||0000-0003-0027-8769 Vieira, Ricardo Botella-Estrada, Rafael Román-Curto, Concepción|||0000-0001-6147-9412 Ferrándiz-Pulido, Lara Iglesias-Pena, Nicolás|||0000-0002-7282-5015 Ferrándiz, Carlos|||0000-0001-9030-8399 Malvehy, Josep|||0000-0002-6998-914X Quaglino, Pietro Nagore, Eduardo|||0000-0003-3433-8707 |
| author |
Tejera-Vaquerizo, Antonio|||0000-0002-8987-0744 |
| author_facet |
Tejera-Vaquerizo, Antonio|||0000-0002-8987-0744 Boada, Aram|||0000-0001-9809-5308 Ribero, Simone Puig, Susana|||0000-0003-1337-9745 Paradela, Sabela|||0000-0002-6779-6459 Moreno-Ramírez, David|||0000-0002-1301-7974 Cañueto, Javier de Unamuno-Bustos, Blanca Brinca, Ana Descalzo-Gallego, Miguel A. Osella-Abate, Simona|||0000-0002-9886-7694 Cassoni, Paola|||0000-0003-1977-7410 Podlipnik, Sebastian|||0000-0003-4150-0522 Carrera, Cristina|||0000-0003-1608-8820 Vidal-Sicart, Sergi|||0000-0002-6303-3606 Pigem, Ramón|||0000-0002-3224-8241 Toll Abelló, Agustí|||0000-0003-2656-0076 Rull, Ramón|||0000-0002-8345-4598 Alos, Llucìa|||0000-0002-3460-0384 Requena, Celia Bolumar, Isidro Traves, Víctor Pla, Ángel Fernández-Orland, Almudena Jaka, Ane|||0000-0003-2699-1159 Fernández-Figueras, Maria Teresa|||0000-0002-2366-7110 Richarz, Nina Anika|||0000-0003-0027-8769 Vieira, Ricardo Botella-Estrada, Rafael Román-Curto, Concepción|||0000-0001-6147-9412 Ferrándiz-Pulido, Lara Iglesias-Pena, Nicolás|||0000-0002-7282-5015 Ferrándiz, Carlos|||0000-0001-9030-8399 Malvehy, Josep|||0000-0002-6998-914X Quaglino, Pietro Nagore, Eduardo|||0000-0003-3433-8707 |
| author_role |
author |
| author2 |
Boada, Aram|||0000-0001-9809-5308 Ribero, Simone Puig, Susana|||0000-0003-1337-9745 Paradela, Sabela|||0000-0002-6779-6459 Moreno-Ramírez, David|||0000-0002-1301-7974 Cañueto, Javier de Unamuno-Bustos, Blanca Brinca, Ana Descalzo-Gallego, Miguel A. Osella-Abate, Simona|||0000-0002-9886-7694 Cassoni, Paola|||0000-0003-1977-7410 Podlipnik, Sebastian|||0000-0003-4150-0522 Carrera, Cristina|||0000-0003-1608-8820 Vidal-Sicart, Sergi|||0000-0002-6303-3606 Pigem, Ramón|||0000-0002-3224-8241 Toll Abelló, Agustí|||0000-0003-2656-0076 Rull, Ramón|||0000-0002-8345-4598 Alos, Llucìa|||0000-0002-3460-0384 Requena, Celia Bolumar, Isidro Traves, Víctor Pla, Ángel Fernández-Orland, Almudena Jaka, Ane|||0000-0003-2699-1159 Fernández-Figueras, Maria Teresa|||0000-0002-2366-7110 Richarz, Nina Anika|||0000-0003-0027-8769 Vieira, Ricardo Botella-Estrada, Rafael Román-Curto, Concepción|||0000-0001-6147-9412 Ferrándiz-Pulido, Lara Iglesias-Pena, Nicolás|||0000-0002-7282-5015 Ferrándiz, Carlos|||0000-0001-9030-8399 Malvehy, Josep|||0000-0002-6998-914X Quaglino, Pietro Nagore, Eduardo|||0000-0003-3433-8707 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Melanoma Sentinel lymph node biopsy Survival |
| topic |
Melanoma Sentinel lymph node biopsy Survival |
| description |
The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (p < 0.001) and 97.3% vs. 68.7% (p < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/282870 https://dx.doi.org/urn:doi:10.3390/jcm10245878 |
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https://ddd.uab.cat/record/282870 https://dx.doi.org/urn:doi:10.3390/jcm10245878 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00956 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI12/00840 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00716 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00419 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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