Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells

The use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (SiμP) to conjugate bipyridinium-based compounds, able to induce cytotoxicity under regula...

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Authors: Limón, David, Hornickγ, Jessica E., Cai, Kang, Beldjoudi, Yassine, Plaza, José A., Duch, Marta, Pérez García, M. Lluïsa (Maria Lluïsa), Stoddart, J. Frasser
Format: article
Status:Versión aceptada para publicación
Publication Date:2022
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/193984
Online Access:https://hdl.handle.net/2445/193984
Access Level:Open access
Keyword:Càncer
Nanopartícules
Nanoquímica
Cancer
Nanoparticles
Nanochemistry
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spelling Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous CellsLimón, DavidHornickγ, Jessica E.Cai, KangBeldjoudi, YassinePlaza, José A.Duch, MartaPérez García, M. Lluïsa (Maria Lluïsa)Stoddart, J. FrasserCàncerNanopartículesNanoquímicaCancerNanoparticlesNanochemistryThe use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (SiμP) to conjugate bipyridinium-based compounds, able to induce cytotoxicity under regular intracellular conditions. Homogeneous functionalization in suspension was achieved, where the open-chain structure exhibits a more dense packing than cyclic analogues. The microparticles internalized induce high cytotoxicity per particle in cancerous HeLa cells, and the less densely packed functionalization using cyclophanes promotes higher cytotoxicity per bipy than with open-chain analogues. The self-renewing ability of the particles and their proximity to cell membranes may account for increased lipid peroxidation, achieving toxicity at much lower concentrations than that in solution and in less time, inducing highly efficient cytotoxicity in cancerous cells. Keywords: HeLa cells; bipyridinium; cancer; cytotoxicity; lipid peroxidation; polysilicon microparticles.American Chemical Society2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion18 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/193984Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1021/acsnano.1c08090ACS Nano, 2022, vol. 16, p. 5358-5375https://doi.org/10.1021/acsnano.1c08090(c) American Chemical Society , 2022info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1939842026-05-29T05:05:01Z
dc.title.none.fl_str_mv Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
title Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
spellingShingle Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
Limón, David
Càncer
Nanopartícules
Nanoquímica
Cancer
Nanoparticles
Nanochemistry
title_short Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
title_full Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
title_fullStr Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
title_full_unstemmed Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
title_sort Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
dc.creator.none.fl_str_mv Limón, David
Hornickγ, Jessica E.
Cai, Kang
Beldjoudi, Yassine
Plaza, José A.
Duch, Marta
Pérez García, M. Lluïsa (Maria Lluïsa)
Stoddart, J. Frasser
author Limón, David
author_facet Limón, David
Hornickγ, Jessica E.
Cai, Kang
Beldjoudi, Yassine
Plaza, José A.
Duch, Marta
Pérez García, M. Lluïsa (Maria Lluïsa)
Stoddart, J. Frasser
author_role author
author2 Hornickγ, Jessica E.
Cai, Kang
Beldjoudi, Yassine
Plaza, José A.
Duch, Marta
Pérez García, M. Lluïsa (Maria Lluïsa)
Stoddart, J. Frasser
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer
Nanopartícules
Nanoquímica
Cancer
Nanoparticles
Nanochemistry
topic Càncer
Nanopartícules
Nanoquímica
Cancer
Nanoparticles
Nanochemistry
description The use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (SiμP) to conjugate bipyridinium-based compounds, able to induce cytotoxicity under regular intracellular conditions. Homogeneous functionalization in suspension was achieved, where the open-chain structure exhibits a more dense packing than cyclic analogues. The microparticles internalized induce high cytotoxicity per particle in cancerous HeLa cells, and the less densely packed functionalization using cyclophanes promotes higher cytotoxicity per bipy than with open-chain analogues. The self-renewing ability of the particles and their proximity to cell membranes may account for increased lipid peroxidation, achieving toxicity at much lower concentrations than that in solution and in less time, inducing highly efficient cytotoxicity in cancerous cells. Keywords: HeLa cells; bipyridinium; cancer; cytotoxicity; lipid peroxidation; polysilicon microparticles.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193984
url https://hdl.handle.net/2445/193984
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1021/acsnano.1c08090
ACS Nano, 2022, vol. 16, p. 5358-5375
https://doi.org/10.1021/acsnano.1c08090
dc.rights.none.fl_str_mv (c) American Chemical Society , 2022
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Chemical Society , 2022
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425397277392896
score 15,811543

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