Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals
Objective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered inte...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:255428 |
| Acceso en línea: | https://ddd.uab.cat/record/255428 https://dx.doi.org/urn:doi:10.3390/nu13041141 |
| Access Level: | acceso abierto |
| Palabra clave: | Gut microbiota Supplemented Mediterranean diet Lipids Lymphocyte subsets HIV-1 Treg cells |
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Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected IndividualsPastor-Ibáñez, Roque|||0000-0002-0787-4638Blanco-Heredia, Juan|||0000-0001-9526-7450Etcheverry, FlorenciaSánchez-Palomino, SonsolesDíez-Fuertes, Francisco|||0000-0003-2413-9229Casas, Rosa|||0000-0002-0211-9166Navarrete-Muñoz, María ÁngelesCastro Barquero, Sara|||0000-0002-6876-5443Lucero, ConstanzaFernandez, IreneLeal, Lorna|||0000-0001-7887-6027Benito, José Miguel|||0000-0002-7172-049XNoguera-Julian, Marc|||0000-0002-6194-1395Paredes, Roger|||0000-0002-6553-691XRallón, Norma|||0000-0002-4643-247XEstruch, Ramón|||0000-0003-1260-4445Torrents, David|||0000-0002-6086-9037García, Felipe|||0000-0001-7658-5832Gut microbiotaSupplemented Mediterranean dietLipidsLymphocyte subsetsHIV-1Treg cellsObjective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Design: Individuals living with HIV (n = 102) were randomised to receive an SMD with 50 g/day of EVOO and 30 g/day of walnuts (SMD group) or continue with their regular diet (control group) for 12 weeks. Methods: Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. Results: The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. Succinivibrio and Bifidobacterium abundances were influenced by the adherence to the MD and significantly correlated with Treg cells. Conclusion: The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the Bifidobacterium abundances after the intervention, and it was associated to a beneficial profile. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255428https://dx.doi.org/urn:doi:10.3390/nu13041141reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0002Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0013Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-66193-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2554282026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals |
| title |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals |
| spellingShingle |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals Pastor-Ibáñez, Roque|||0000-0002-0787-4638 Gut microbiota Supplemented Mediterranean diet Lipids Lymphocyte subsets HIV-1 Treg cells |
| title_short |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals |
| title_full |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals |
| title_fullStr |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals |
| title_full_unstemmed |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals |
| title_sort |
Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals |
| dc.creator.none.fl_str_mv |
Pastor-Ibáñez, Roque|||0000-0002-0787-4638 Blanco-Heredia, Juan|||0000-0001-9526-7450 Etcheverry, Florencia Sánchez-Palomino, Sonsoles Díez-Fuertes, Francisco|||0000-0003-2413-9229 Casas, Rosa|||0000-0002-0211-9166 Navarrete-Muñoz, María Ángeles Castro Barquero, Sara|||0000-0002-6876-5443 Lucero, Constanza Fernandez, Irene Leal, Lorna|||0000-0001-7887-6027 Benito, José Miguel|||0000-0002-7172-049X Noguera-Julian, Marc|||0000-0002-6194-1395 Paredes, Roger|||0000-0002-6553-691X Rallón, Norma|||0000-0002-4643-247X Estruch, Ramón|||0000-0003-1260-4445 Torrents, David|||0000-0002-6086-9037 García, Felipe|||0000-0001-7658-5832 |
| author |
Pastor-Ibáñez, Roque|||0000-0002-0787-4638 |
| author_facet |
Pastor-Ibáñez, Roque|||0000-0002-0787-4638 Blanco-Heredia, Juan|||0000-0001-9526-7450 Etcheverry, Florencia Sánchez-Palomino, Sonsoles Díez-Fuertes, Francisco|||0000-0003-2413-9229 Casas, Rosa|||0000-0002-0211-9166 Navarrete-Muñoz, María Ángeles Castro Barquero, Sara|||0000-0002-6876-5443 Lucero, Constanza Fernandez, Irene Leal, Lorna|||0000-0001-7887-6027 Benito, José Miguel|||0000-0002-7172-049X Noguera-Julian, Marc|||0000-0002-6194-1395 Paredes, Roger|||0000-0002-6553-691X Rallón, Norma|||0000-0002-4643-247X Estruch, Ramón|||0000-0003-1260-4445 Torrents, David|||0000-0002-6086-9037 García, Felipe|||0000-0001-7658-5832 |
| author_role |
author |
| author2 |
Blanco-Heredia, Juan|||0000-0001-9526-7450 Etcheverry, Florencia Sánchez-Palomino, Sonsoles Díez-Fuertes, Francisco|||0000-0003-2413-9229 Casas, Rosa|||0000-0002-0211-9166 Navarrete-Muñoz, María Ángeles Castro Barquero, Sara|||0000-0002-6876-5443 Lucero, Constanza Fernandez, Irene Leal, Lorna|||0000-0001-7887-6027 Benito, José Miguel|||0000-0002-7172-049X Noguera-Julian, Marc|||0000-0002-6194-1395 Paredes, Roger|||0000-0002-6553-691X Rallón, Norma|||0000-0002-4643-247X Estruch, Ramón|||0000-0003-1260-4445 Torrents, David|||0000-0002-6086-9037 García, Felipe|||0000-0001-7658-5832 |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Gut microbiota Supplemented Mediterranean diet Lipids Lymphocyte subsets HIV-1 Treg cells |
| topic |
Gut microbiota Supplemented Mediterranean diet Lipids Lymphocyte subsets HIV-1 Treg cells |
| description |
Objective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Design: Individuals living with HIV (n = 102) were randomised to receive an SMD with 50 g/day of EVOO and 30 g/day of walnuts (SMD group) or continue with their regular diet (control group) for 12 weeks. Methods: Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. Results: The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. Succinivibrio and Bifidobacterium abundances were influenced by the adherence to the MD and significantly correlated with Treg cells. Conclusion: The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the Bifidobacterium abundances after the intervention, and it was associated to a beneficial profile. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/255428 https://dx.doi.org/urn:doi:10.3390/nu13041141 |
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https://ddd.uab.cat/record/255428 https://dx.doi.org/urn:doi:10.3390/nu13041141 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0002 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0013 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-66193-R |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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