RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously unforeseen link between RNA and DNA metabolism, which is often related to t...

Descripción completa

Detalles Bibliográficos
Autores: Luna Varo, Rosa María, Gómez González, Belén, Aguilera López, Andrés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/162009
Acceso en línea:https://hdl.handle.net/11441/162009
https://doi.org/10.1101/gad.351853.124.
Access Level:acceso abierto
Palabra clave:DNA–RNA hybrids
R-loops
RNA biogenesis
RNA metabolism
genome instability
helicases
id ES_fc07158d01a9c2905dfd8f444d55bd40
oai_identifier_str oai:idus.us.es:11441/162009
network_acronym_str ES
network_name_str España
repository_id_str
spelling RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.Luna Varo, Rosa MaríaGómez González, BelénAguilera López, AndrésDNA–RNA hybridsR-loopsRNA biogenesisRNA metabolismgenome instabilityhelicasesGenome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously unforeseen link between RNA and DNA metabolism, which is often related to the accumulation of DNA–RNA hybrids and R-loops. In addition to physiological roles, R-loops interfere with DNA replication and repair, providing a molecular scenario for the origin of genome instability. Here, we review current knowledge on the multiple RNA factors that prevent or resolve R-loops and consequent transcription–replication conflicts and thus act as modulators of genome dynamics.Ministerio de Ciencia e Innovación/ AEI/10.13039/501100011033 y “FEDER: una forma de hacer Europa”Fundación Caixa de Investigación - LCF/PR/HR22/52420014Cold Spring Harbor Laboratory PressGenéticaMinisterio de Ciencia e Innovación (MICIN). EspañaAgencia Estatal de Investigación. EspañaEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)Fundación Caixa de Investigación. EspañaJunta de Andalucía2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/162009https://doi.org/10.1101/gad.351853.124.reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésGenes & Development, 38 (11-12), 504-527.PID2022- 138251NB-I00LCF/PR/HR22/52420014https://dx.doi.org/10.1101/gad.351853.124.info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1620092026-06-17T12:51:07Z
dc.title.none.fl_str_mv RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
title RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
spellingShingle RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
Luna Varo, Rosa María
DNA–RNA hybrids
R-loops
RNA biogenesis
RNA metabolism
genome instability
helicases
title_short RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
title_full RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
title_fullStr RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
title_full_unstemmed RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
title_sort RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
dc.creator.none.fl_str_mv Luna Varo, Rosa María
Gómez González, Belén
Aguilera López, Andrés
author Luna Varo, Rosa María
author_facet Luna Varo, Rosa María
Gómez González, Belén
Aguilera López, Andrés
author_role author
author2 Gómez González, Belén
Aguilera López, Andrés
author2_role author
author
dc.contributor.none.fl_str_mv Genética
Ministerio de Ciencia e Innovación (MICIN). España
Agencia Estatal de Investigación. España
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
Fundación Caixa de Investigación. España
Junta de Andalucía
dc.subject.none.fl_str_mv DNA–RNA hybrids
R-loops
RNA biogenesis
RNA metabolism
genome instability
helicases
topic DNA–RNA hybrids
R-loops
RNA biogenesis
RNA metabolism
genome instability
helicases
description Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously unforeseen link between RNA and DNA metabolism, which is often related to the accumulation of DNA–RNA hybrids and R-loops. In addition to physiological roles, R-loops interfere with DNA replication and repair, providing a molecular scenario for the origin of genome instability. Here, we review current knowledge on the multiple RNA factors that prevent or resolve R-loops and consequent transcription–replication conflicts and thus act as modulators of genome dynamics.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/162009
https://doi.org/10.1101/gad.351853.124.
url https://hdl.handle.net/11441/162009
https://doi.org/10.1101/gad.351853.124.
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Genes & Development, 38 (11-12), 504-527.
PID2022- 138251NB-I00
LCF/PR/HR22/52420014
https://dx.doi.org/10.1101/gad.351853.124.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425384047509505
score 15,81155

Similares en LA Referencia