The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)

Pizarro, David; Romero, Ignacio; Pérez-Mies, Belén; Redondo Sánchez, Andrés|||0000-0002-7257-5642; Caniego-Casas, Tamara; Carretero-Barrio, Irene|||0000-0003-1986-2965; Cristóbal, Eva; Gutiérrez-Pecharromán, Ana; Santaballa, Ana|||0000-0001-7763-320X; D'Angelo, Emanuela|||0000-0002-6173-1806; Hardisson, David|||0000-0002-2183-3699; Vieites, Begoña; Matías-Guiu, Xavier|||0000-0002-7201-6605; Estévez-García, Purificación; Guerra, Eva|||0000-0003-1910-4451; Prat, Jaime|||0000-0002-9787-3304; Poveda, Andrés; López-Guerrero, J.A.|||0000-0002-7369-8388; Palacios, José|||0000-0002-6730-5066

The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)

Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to deter...

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Authors:	Pizarro, David, Romero, Ignacio, Pérez-Mies, Belén, Redondo Sánchez, Andrés\|\|\|0000-0002-7257-5642, Caniego-Casas, Tamara, Carretero-Barrio, Irene\|\|\|0000-0003-1986-2965, Cristóbal, Eva, Gutiérrez-Pecharromán, Ana, Santaballa, Ana\|\|\|0000-0001-7763-320X, D'Angelo, Emanuela\|\|\|0000-0002-6173-1806, Hardisson, David\|\|\|0000-0002-2183-3699, Vieites, Begoña, Matías-Guiu, Xavier\|\|\|0000-0002-7201-6605, Estévez-García, Purificación, Guerra, Eva\|\|\|0000-0003-1910-4451, Prat, Jaime\|\|\|0000-0002-9787-3304, Poveda, Andrés, López-Guerrero, J.A.\|\|\|0000-0002-7369-8388, Palacios, José\|\|\|0000-0002-6730-5066
Format:	article
Publication Date:	2023
Country:	España
Institution:	Universitat Autònoma de Barcelona
Repository:	Dipòsit Digital de Documents de la UAB
Language:	English
OAI Identifier:	oai:ddd.uab.cat:319576
Online Access:	https://ddd.uab.cat/record/319576 https://dx.doi.org/urn:doi:10.3390/ijms241311183
Access Level:	Open access
Keyword:	High-grade serous ovarian carcinoma Early stage PD-L1 BRCA TMB

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network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)Pizarro, DavidRomero, IgnacioPérez-Mies, BelénRedondo Sánchez, Andrés\|\|\|0000-0002-7257-5642Caniego-Casas, TamaraCarretero-Barrio, Irene\|\|\|0000-0003-1986-2965Cristóbal, EvaGutiérrez-Pecharromán, AnaSantaballa, Ana\|\|\|0000-0001-7763-320XD'Angelo, Emanuela\|\|\|0000-0002-6173-1806Hardisson, David\|\|\|0000-0002-2183-3699Vieites, BegoñaMatías-Guiu, Xavier\|\|\|0000-0002-7201-6605Estévez-García, PurificaciónGuerra, Eva\|\|\|0000-0003-1910-4451Prat, Jaime\|\|\|0000-0002-9787-3304Poveda, AndrésLópez-Guerrero, J.A.\|\|\|0000-0002-7369-8388Palacios, José\|\|\|0000-0002-6730-5066High-grade serous ovarian carcinomaEarly stagePD-L1BRCATMBEarly stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, BRCA mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO). Centralized histological typing was performed based on morphological and immunohistochemical features. Intraepithelial (i) and stromal (s) CD8+ and CD4+ T cells and PD-L1 were evaluated on tissue microarrays by immunohistochemistry. BRCA1 and BRCA2 mutation status and TMB were analyzed in tumor DNA using next-generation sequencing. The study included 124 tumors. High iCD8+ (. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/319576https://dx.doi.org/urn:doi:10.3390/ijms241311183reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01331Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/01892Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PMP22/00054Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB16/12/00316European Development Regional Fund 'A way to achieve Europe' (FEDER) CB16/12/00316Spanish Group of Research in Ovarian Cancer (GEICO group) CB16/12/00316Spanish Association Against Cancer Scientific Foundation (AECC) CB16/12/00316open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3195762026-06-06T12:50:31Z
dc.title.none.fl_str_mv	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
title	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
spellingShingle	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO) Pizarro, David High-grade serous ovarian carcinoma Early stage PD-L1 BRCA TMB
title_short	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
title_full	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
title_fullStr	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
title_full_unstemmed	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
title_sort	The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
dc.creator.none.fl_str_mv	Pizarro, David Romero, Ignacio Pérez-Mies, Belén Redondo Sánchez, Andrés\|\|\|0000-0002-7257-5642 Caniego-Casas, Tamara Carretero-Barrio, Irene\|\|\|0000-0003-1986-2965 Cristóbal, Eva Gutiérrez-Pecharromán, Ana Santaballa, Ana\|\|\|0000-0001-7763-320X D'Angelo, Emanuela\|\|\|0000-0002-6173-1806 Hardisson, David\|\|\|0000-0002-2183-3699 Vieites, Begoña Matías-Guiu, Xavier\|\|\|0000-0002-7201-6605 Estévez-García, Purificación Guerra, Eva\|\|\|0000-0003-1910-4451 Prat, Jaime\|\|\|0000-0002-9787-3304 Poveda, Andrés López-Guerrero, J.A.\|\|\|0000-0002-7369-8388 Palacios, José\|\|\|0000-0002-6730-5066
author	Pizarro, David
author_facet	Pizarro, David Romero, Ignacio Pérez-Mies, Belén Redondo Sánchez, Andrés\|\|\|0000-0002-7257-5642 Caniego-Casas, Tamara Carretero-Barrio, Irene\|\|\|0000-0003-1986-2965 Cristóbal, Eva Gutiérrez-Pecharromán, Ana Santaballa, Ana\|\|\|0000-0001-7763-320X D'Angelo, Emanuela\|\|\|0000-0002-6173-1806 Hardisson, David\|\|\|0000-0002-2183-3699 Vieites, Begoña Matías-Guiu, Xavier\|\|\|0000-0002-7201-6605 Estévez-García, Purificación Guerra, Eva\|\|\|0000-0003-1910-4451 Prat, Jaime\|\|\|0000-0002-9787-3304 Poveda, Andrés López-Guerrero, J.A.\|\|\|0000-0002-7369-8388 Palacios, José\|\|\|0000-0002-6730-5066
author_role	author
author2	Romero, Ignacio Pérez-Mies, Belén Redondo Sánchez, Andrés\|\|\|0000-0002-7257-5642 Caniego-Casas, Tamara Carretero-Barrio, Irene\|\|\|0000-0003-1986-2965 Cristóbal, Eva Gutiérrez-Pecharromán, Ana Santaballa, Ana\|\|\|0000-0001-7763-320X D'Angelo, Emanuela\|\|\|0000-0002-6173-1806 Hardisson, David\|\|\|0000-0002-2183-3699 Vieites, Begoña Matías-Guiu, Xavier\|\|\|0000-0002-7201-6605 Estévez-García, Purificación Guerra, Eva\|\|\|0000-0003-1910-4451 Prat, Jaime\|\|\|0000-0002-9787-3304 Poveda, Andrés López-Guerrero, J.A.\|\|\|0000-0002-7369-8388 Palacios, José\|\|\|0000-0002-6730-5066
author2_role	author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	High-grade serous ovarian carcinoma Early stage PD-L1 BRCA TMB
topic	High-grade serous ovarian carcinoma Early stage PD-L1 BRCA TMB
description	Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, BRCA mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO). Centralized histological typing was performed based on morphological and immunohistochemical features. Intraepithelial (i) and stromal (s) CD8+ and CD4+ T cells and PD-L1 were evaluated on tissue microarrays by immunohistochemistry. BRCA1 and BRCA2 mutation status and TMB were analyzed in tumor DNA using next-generation sequencing. The study included 124 tumors. High iCD8+ (.
publishDate	2023
dc.date.none.fl_str_mv	2 2023-01-01 2023 2023-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/319576 https://dx.doi.org/urn:doi:10.3390/ijms241311183
url	https://ddd.uab.cat/record/319576 https://dx.doi.org/urn:doi:10.3390/ijms241311183
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01331 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/01892 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PMP22/00054 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB16/12/00316 European Development Regional Fund 'A way to achieve Europe' (FEDER) CB16/12/00316 Spanish Group of Research in Ovarian Cancer (GEICO group) CB16/12/00316 Spanish Association Against Cancer Scientific Foundation (AECC) CB16/12/00316
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)

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