The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)

Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to deter...

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Detalles Bibliográficos
Autores: Pizarro, David, Romero, Ignacio, Pérez-Mies, Belén, Redondo Sánchez, Andrés|||0000-0002-7257-5642, Caniego-Casas, Tamara, Carretero-Barrio, Irene|||0000-0003-1986-2965, Cristóbal, Eva, Gutiérrez-Pecharromán, Ana, Santaballa, Ana|||0000-0001-7763-320X, D'Angelo, Emanuela|||0000-0002-6173-1806, Hardisson, David|||0000-0002-2183-3699, Vieites, Begoña, Matías-Guiu, Xavier|||0000-0002-7201-6605, Estévez-García, Purificación, Guerra, Eva|||0000-0003-1910-4451, Prat, Jaime|||0000-0002-9787-3304, Poveda, Andrés, López-Guerrero, J.A.|||0000-0002-7369-8388, Palacios, José|||0000-0002-6730-5066
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:319576
Acceso en línea:https://ddd.uab.cat/record/319576
https://dx.doi.org/urn:doi:10.3390/ijms241311183
Access Level:acceso abierto
Palabra clave:High-grade serous ovarian carcinoma
Early stage
PD-L1
BRCA
TMB
Descripción
Sumario:Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, BRCA mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO). Centralized histological typing was performed based on morphological and immunohistochemical features. Intraepithelial (i) and stromal (s) CD8+ and CD4+ T cells and PD-L1 were evaluated on tissue microarrays by immunohistochemistry. BRCA1 and BRCA2 mutation status and TMB were analyzed in tumor DNA using next-generation sequencing. The study included 124 tumors. High iCD8+ (.

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