Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses

Procalcitonin (PCT) increased in the case of systemic inflammatory response syndrome (SIRS), especially due to bacterial infection. The correlation between SIRS score and plasma PCT levels in horses have not been evaluated, and no studies investigated plasma PCT concentration over time. In the prese...

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Autores: Nocera, Irene|||0000-0001-9536-4453, Bonelli, Francesca|||0000-0002-4119-7781, Vitale, Valentina|||0000-0003-2273-5377, Meucci, Valentina|||0000-0001-5672-7856, Conte, Giuseppe|||0000-0002-7257-4762, José Cunilleras, Eduard|||0000-0002-4536-7717, Gracia-Calvo, Luis Alfonso, Sgorbini, Micaela|||0000-0002-0294-1803
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:269522
Acceso en línea:https://ddd.uab.cat/record/269522
https://dx.doi.org/urn:doi:10.3390/ani11072015
Access Level:acceso abierto
Palabra clave:Horse
Colic
Procalcitonin
Systemic inflammatory response syndrome
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spelling Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic HorsesNocera, Irene|||0000-0001-9536-4453Bonelli, Francesca|||0000-0002-4119-7781Vitale, Valentina|||0000-0003-2273-5377Meucci, Valentina|||0000-0001-5672-7856Conte, Giuseppe|||0000-0002-7257-4762José Cunilleras, Eduard|||0000-0002-4536-7717Gracia-Calvo, Luis AlfonsoSgorbini, Micaela|||0000-0002-0294-1803HorseColicProcalcitoninSystemic inflammatory response syndromeProcalcitonin (PCT) increased in the case of systemic inflammatory response syndrome (SIRS), especially due to bacterial infection. The correlation between SIRS score and plasma PCT levels in horses have not been evaluated, and no studies investigated plasma PCT concentration over time. In the present study, PCT and SIRS score were evaluated in colic horses at admission to the hospital and at 24, 48, 72 and 96 h. Statistically differences were detected between healthy vs. all colic horses and between healthy vs. SIRS positive or SIRS negative horses. No correlation was observed between SIRS score and PCT. This suggests a role of plasmatic PCT as good biomarker for colic. Colic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potential correlation, to verify the usefulness of PCT for the evaluation of SIRS severity. Ninety-one horses were included; 43/91 were healthy, on basis of physical examination, blood work and SIRS score (score = 0), while 48/91 were sick colic horses, classified as SIRS-negative (score < 2) and positive (score ≥ 2). Moreover, a 0-6 point-scale SIRS score was calculated (assessing mucous membrane color and blood lactate concentration). PCT was evaluated at admission, and at 24, 48, 72 and 96 h, using a commercial kit for equine species. We verified by the ANOVA test PCT differences between healthy vs. colic horses, healthy vs. SIRS-negative or SIRS-positive colic horses, at all sampling times, and the correlation between the SIRS score at admission with the SIRS score. Statistically significant differences were detected between healthy vs. all colic horses and between healthy vs. SIRS-positive or negative horses at all sampling times. No correlation was observed between the SIRS score at admission and PCT values. PCT was statistically higher in colic horses compared to the healthy ones, suggesting a role as a biomarker for colic. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/269522https://dx.doi.org/urn:doi:10.3390/ani11072015reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2695222026-06-06T12:50:31Z
dc.title.none.fl_str_mv Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
title Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
spellingShingle Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
Nocera, Irene|||0000-0001-9536-4453
Horse
Colic
Procalcitonin
Systemic inflammatory response syndrome
title_short Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
title_full Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
title_fullStr Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
title_full_unstemmed Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
title_sort Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses
dc.creator.none.fl_str_mv Nocera, Irene|||0000-0001-9536-4453
Bonelli, Francesca|||0000-0002-4119-7781
Vitale, Valentina|||0000-0003-2273-5377
Meucci, Valentina|||0000-0001-5672-7856
Conte, Giuseppe|||0000-0002-7257-4762
José Cunilleras, Eduard|||0000-0002-4536-7717
Gracia-Calvo, Luis Alfonso
Sgorbini, Micaela|||0000-0002-0294-1803
author Nocera, Irene|||0000-0001-9536-4453
author_facet Nocera, Irene|||0000-0001-9536-4453
Bonelli, Francesca|||0000-0002-4119-7781
Vitale, Valentina|||0000-0003-2273-5377
Meucci, Valentina|||0000-0001-5672-7856
Conte, Giuseppe|||0000-0002-7257-4762
José Cunilleras, Eduard|||0000-0002-4536-7717
Gracia-Calvo, Luis Alfonso
Sgorbini, Micaela|||0000-0002-0294-1803
author_role author
author2 Bonelli, Francesca|||0000-0002-4119-7781
Vitale, Valentina|||0000-0003-2273-5377
Meucci, Valentina|||0000-0001-5672-7856
Conte, Giuseppe|||0000-0002-7257-4762
José Cunilleras, Eduard|||0000-0002-4536-7717
Gracia-Calvo, Luis Alfonso
Sgorbini, Micaela|||0000-0002-0294-1803
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Horse
Colic
Procalcitonin
Systemic inflammatory response syndrome
topic Horse
Colic
Procalcitonin
Systemic inflammatory response syndrome
description Procalcitonin (PCT) increased in the case of systemic inflammatory response syndrome (SIRS), especially due to bacterial infection. The correlation between SIRS score and plasma PCT levels in horses have not been evaluated, and no studies investigated plasma PCT concentration over time. In the present study, PCT and SIRS score were evaluated in colic horses at admission to the hospital and at 24, 48, 72 and 96 h. Statistically differences were detected between healthy vs. all colic horses and between healthy vs. SIRS positive or SIRS negative horses. No correlation was observed between SIRS score and PCT. This suggests a role of plasmatic PCT as good biomarker for colic. Colic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potential correlation, to verify the usefulness of PCT for the evaluation of SIRS severity. Ninety-one horses were included; 43/91 were healthy, on basis of physical examination, blood work and SIRS score (score = 0), while 48/91 were sick colic horses, classified as SIRS-negative (score < 2) and positive (score ≥ 2). Moreover, a 0-6 point-scale SIRS score was calculated (assessing mucous membrane color and blood lactate concentration). PCT was evaluated at admission, and at 24, 48, 72 and 96 h, using a commercial kit for equine species. We verified by the ANOVA test PCT differences between healthy vs. colic horses, healthy vs. SIRS-negative or SIRS-positive colic horses, at all sampling times, and the correlation between the SIRS score at admission with the SIRS score. Statistically significant differences were detected between healthy vs. all colic horses and between healthy vs. SIRS-positive or negative horses at all sampling times. No correlation was observed between the SIRS score at admission and PCT values. PCT was statistically higher in colic horses compared to the healthy ones, suggesting a role as a biomarker for colic.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/269522
https://dx.doi.org/urn:doi:10.3390/ani11072015
url https://ddd.uab.cat/record/269522
https://dx.doi.org/urn:doi:10.3390/ani11072015
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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