An Integrated 12C/13C Exchange Platform for Accessing Isotopically-Labeled Ketones via Dual Catalytic C–C Bond-Functionalization
Herein, we describe an integrated diacylation/acylation platform that formally converts simple ketones into their 13C-labeled homologues. The method relies on the propensity of proaromatic dihydroquinazolinones to generate open-shell species via C–C bond-functionalization aided by photoinduced singl...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/489068 |
| Acceso en línea: | http://hdl.handle.net/2072/489068 https://doi.org/10.1021/acscatal.5c06571 |
| Access Level: | acceso abierto |
| Palabra clave: | Química 54 |
| Sumario: | Herein, we describe an integrated diacylation/acylation platform that formally converts simple ketones into their 13C-labeled homologues. The method relies on the propensity of proaromatic dihydroquinazolinones to generate open-shell species via C–C bond-functionalization aided by photoinduced single-electron transfer prior to interception with a properly labeled 13C-carbonyl derivative. The protocol is characterized by its broad applicability, thus offering a distinct gateway to access 13C-labeled ketones from their parent nonlabeled analogues. |
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