A set of simple cell processes is sufficient to model spiral cleavage

During cleavage, different cellular processes cause the zygote to become partitioned into a set of cells with a specific spatial arrangement. These processes include the orientation of cell division according to: an animal-vegetal gradient; the main axis (Hertwig’s rule) of the cell; and the contact...

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Detalles Bibliográficos
Autores: Brun-Usan, Miguel, Marín-Riera, Miquel, Grande, Cristina, Truchado-García, Marta, Salazar-Ciudad, Isaac
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/165513
Acceso en línea:http://hdl.handle.net/10261/165513
Access Level:acceso abierto
Palabra clave:Developmental rules
Spiral cleavage
Developmental morphospace
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spelling A set of simple cell processes is sufficient to model spiral cleavageBrun-Usan, MiguelMarín-Riera, MiquelGrande, CristinaTruchado-García, MartaSalazar-Ciudad, IsaacDevelopmental rulesSpiral cleavageDevelopmental morphospaceDuring cleavage, different cellular processes cause the zygote to become partitioned into a set of cells with a specific spatial arrangement. These processes include the orientation of cell division according to: an animal-vegetal gradient; the main axis (Hertwig’s rule) of the cell; and the contact areas between cells or the perpendicularity between consecutive cell divisions (Sachs’ rule). Cell adhesion and cortical rotation have also been proposed to be involved in spiral cleavage.We use a computational model of cell and tissue biomechanics to account for the different existing hypotheses about how the specific spatial arrangement of cells in spiral cleavage arises during development. Cell polarization by an animal-vegetal gradient, a bias to perpendicularity between consecutive cell divisions (Sachs’ rule), cortical rotation and cell adhesion, when combined, reproduce the spiral cleavage, whereas other combinations of processes cannot. Specifically, cortical rotation is necessary at the 8-cell stage to direct all micromeres in the same direction. By varying the relative strength of these processes, we reproduce the spatial arrangement of cells in the blastulae of seven different invertebrate species.Ministerio de Ciencia y Tecnologı́a (BFU2010-17044 to I.S.-C., BES2011-046641 to M.B.-U. and BES 2012-052214 to M.T.-G.), by the Generalitat de Catalunya (2013FI-B00439 to M.M.-R.), and by Universidad Autónoma de Madrid and Ministerio de Ciencia y Tecnologı́a (CGL2011-29916 to C.G.)Peer ReviewedCompany of BiologistsGeneralitat de CatalunyaUniversidad Autónoma de MadridMinisterio de Ciencia y Tecnología (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820172018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/165513reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1655132026-05-22T06:33:51Z
dc.title.none.fl_str_mv A set of simple cell processes is sufficient to model spiral cleavage
title A set of simple cell processes is sufficient to model spiral cleavage
spellingShingle A set of simple cell processes is sufficient to model spiral cleavage
Brun-Usan, Miguel
Developmental rules
Spiral cleavage
Developmental morphospace
title_short A set of simple cell processes is sufficient to model spiral cleavage
title_full A set of simple cell processes is sufficient to model spiral cleavage
title_fullStr A set of simple cell processes is sufficient to model spiral cleavage
title_full_unstemmed A set of simple cell processes is sufficient to model spiral cleavage
title_sort A set of simple cell processes is sufficient to model spiral cleavage
dc.creator.none.fl_str_mv Brun-Usan, Miguel
Marín-Riera, Miquel
Grande, Cristina
Truchado-García, Marta
Salazar-Ciudad, Isaac
author Brun-Usan, Miguel
author_facet Brun-Usan, Miguel
Marín-Riera, Miquel
Grande, Cristina
Truchado-García, Marta
Salazar-Ciudad, Isaac
author_role author
author2 Marín-Riera, Miquel
Grande, Cristina
Truchado-García, Marta
Salazar-Ciudad, Isaac
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Generalitat de Catalunya
Universidad Autónoma de Madrid
Ministerio de Ciencia y Tecnología (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Developmental rules
Spiral cleavage
Developmental morphospace
topic Developmental rules
Spiral cleavage
Developmental morphospace
description During cleavage, different cellular processes cause the zygote to become partitioned into a set of cells with a specific spatial arrangement. These processes include the orientation of cell division according to: an animal-vegetal gradient; the main axis (Hertwig’s rule) of the cell; and the contact areas between cells or the perpendicularity between consecutive cell divisions (Sachs’ rule). Cell adhesion and cortical rotation have also been proposed to be involved in spiral cleavage.We use a computational model of cell and tissue biomechanics to account for the different existing hypotheses about how the specific spatial arrangement of cells in spiral cleavage arises during development. Cell polarization by an animal-vegetal gradient, a bias to perpendicularity between consecutive cell divisions (Sachs’ rule), cortical rotation and cell adhesion, when combined, reproduce the spiral cleavage, whereas other combinations of processes cannot. Specifically, cortical rotation is necessary at the 8-cell stage to direct all micromeres in the same direction. By varying the relative strength of these processes, we reproduce the spatial arrangement of cells in the blastulae of seven different invertebrate species.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/165513
url http://hdl.handle.net/10261/165513
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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