Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart

Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mou...

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Detalhes bibliográficos
Autores: Villa del Campo, Cristina, Claveria, Cristina, Sierra, Rocio, Torres, Miguel
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/5540
Acesso em linha:http://hdl.handle.net/20.500.12105/5540
Access Level:acceso abierto
Palavra-chave:CARDIAC PROGENITOR CELLS
C-MYC
MYOCYTE HYPERTROPHY
CIRCADIAN CLOCK
DNA-SYNTHESIS
IN-VIVO
DROSOPHILA
RECEPTOR
PATHWAY
DEATH
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spelling Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian HeartVilla del Campo, CristinaClaveria, CristinaSierra, RocioTorres, MiguelCARDIAC PROGENITOR CELLSC-MYCMYOCYTE HYPERTROPHYCIRCADIAN CLOCKDNA-SYNTHESISIN-VIVODROSOPHILARECEPTORPATHWAYDEATHHeterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardio-myocyte-replacement strategy.Cell PressMinisterio de Economía y Competitividad (España)Comunidad de Madrid (España)Fundación ProCNIC20172017-12-0120142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/octet-streamhttp://hdl.handle.net/20.500.12105/5540reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/55402026-06-12T12:43:37Z
dc.title.none.fl_str_mv Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
title Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
spellingShingle Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
Villa del Campo, Cristina
CARDIAC PROGENITOR CELLS
C-MYC
MYOCYTE HYPERTROPHY
CIRCADIAN CLOCK
DNA-SYNTHESIS
IN-VIVO
DROSOPHILA
RECEPTOR
PATHWAY
DEATH
title_short Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
title_full Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
title_fullStr Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
title_full_unstemmed Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
title_sort Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
dc.creator.none.fl_str_mv Villa del Campo, Cristina
Claveria, Cristina
Sierra, Rocio
Torres, Miguel
author Villa del Campo, Cristina
author_facet Villa del Campo, Cristina
Claveria, Cristina
Sierra, Rocio
Torres, Miguel
author_role author
author2 Claveria, Cristina
Sierra, Rocio
Torres, Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Comunidad de Madrid (España)
Fundación ProCNIC
dc.subject.none.fl_str_mv CARDIAC PROGENITOR CELLS
C-MYC
MYOCYTE HYPERTROPHY
CIRCADIAN CLOCK
DNA-SYNTHESIS
IN-VIVO
DROSOPHILA
RECEPTOR
PATHWAY
DEATH
topic CARDIAC PROGENITOR CELLS
C-MYC
MYOCYTE HYPERTROPHY
CIRCADIAN CLOCK
DNA-SYNTHESIS
IN-VIVO
DROSOPHILA
RECEPTOR
PATHWAY
DEATH
description Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardio-myocyte-replacement strategy.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
2014
2014-01-01
2017
2017-12-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/5540
url http://hdl.handle.net/20.500.12105/5540
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/octet-stream
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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