Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations
Cytogenetic analysis of unstimulated short-term bone marrow cell cultures was performed on 280 patients with multiple myeloma and related disorders. In 65% of the cases, an additional short term B-cell stimulated culture was also examined. Chromosomally abnormal clones were found in 31% of the patie...
| Authors: | , , , , , , , , , |
|---|---|
| Format: | article |
| Publication Date: | 1997 |
| Country: | España |
| Institution: | Universidad de Navarra |
| Repository: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Language: | English |
| OAI Identifier: | oai:dadun.unav.edu:10171/19794 |
| Online Access: | https://hdl.handle.net/10171/19794 |
| Access Level: | Open access |
| Keyword: | Chromosome Aberrations Chromosome Disorders Multiple Myeloma/genetics |
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Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlationsCalasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086Cigudosa, J.C. (Juan Cruz)|||/items/81ac2a66-7c9e-4a8d-b44b-92f7552c954aOdero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251Ferreira, C. (C.)|||/items/e7b44101-8501-434c-84ea-ac41fed371a9Ardanaz, M.T. (M.T.)|||/items/366393f3-d1f1-4c58-84b1-89b43ca5b522Fraile, A. (A.)|||/items/802cca22-d87a-45a9-a20a-af3b9861beb5Carrasco, J. (J.L.)|||/items/d41251ca-1836-4195-90fa-055c1f44f330Sole, F. (Francesc)|||/items/f2e2b40d-3895-49b7-a41a-9f01a078406dCuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6Gullon, A. (Arturo)|||/items/ca7ff744-c2e8-470e-952a-70bd1d9e66bfChromosome AberrationsChromosome DisordersMultiple Myeloma/geneticsCytogenetic analysis of unstimulated short-term bone marrow cell cultures was performed on 280 patients with multiple myeloma and related disorders. In 65% of the cases, an additional short term B-cell stimulated culture was also examined. Chromosomally abnormal clones were found in 31% of the patients, 15% in Waldenström macroglobulinemia. 25% in monoclonal gammopathies, 33% in multiple myeloma, and 50% in plasma cell leukemia. Three primary chromosomal breakpoints were recurrently involved: 14q32, 16q22, and 22q11. Structural rearrangements of chromosome 1 were the most frequent (26% of the abnormal cases), but always as a secondary change. Rearrangements of band 14q32 were found in 22% of the abnormal cases. Among the multiple myeloma patients who showed an abnormal karyotype, 33 (46%) were hyperdiploid, most frequently, with 52-56 chromosomes, 29 patients (40%) were pseudodiploid, and the remaining 12 cases (14%) were hypodiploid. A highly significant relation was observed between the presence of an abnormal karyotype and the following clinical parameters: stage III (P = 0.0001), bone marrow plasma cell infiltration greater than 30% (P = 0.0001), presence of bone lesions (P = 0.0009), and beta 2-microglobulin levels greater than 4 mg/L (P = 0.0001).Wiley-BlackwellDadun. Depósito Académico Digital Universidad de Navarra20112011-11-1519971997-01-0119971997-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/19794reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/197942026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations |
| title |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations |
| spellingShingle |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Chromosome Aberrations Chromosome Disorders Multiple Myeloma/genetics |
| title_short |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations |
| title_full |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations |
| title_fullStr |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations |
| title_full_unstemmed |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations |
| title_sort |
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations |
| dc.creator.none.fl_str_mv |
Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Cigudosa, J.C. (Juan Cruz)|||/items/81ac2a66-7c9e-4a8d-b44b-92f7552c954a Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251 Ferreira, C. (C.)|||/items/e7b44101-8501-434c-84ea-ac41fed371a9 Ardanaz, M.T. (M.T.)|||/items/366393f3-d1f1-4c58-84b1-89b43ca5b522 Fraile, A. (A.)|||/items/802cca22-d87a-45a9-a20a-af3b9861beb5 Carrasco, J. (J.L.)|||/items/d41251ca-1836-4195-90fa-055c1f44f330 Sole, F. (Francesc)|||/items/f2e2b40d-3895-49b7-a41a-9f01a078406d Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6 Gullon, A. (Arturo)|||/items/ca7ff744-c2e8-470e-952a-70bd1d9e66bf |
| author |
Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 |
| author_facet |
Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Cigudosa, J.C. (Juan Cruz)|||/items/81ac2a66-7c9e-4a8d-b44b-92f7552c954a Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251 Ferreira, C. (C.)|||/items/e7b44101-8501-434c-84ea-ac41fed371a9 Ardanaz, M.T. (M.T.)|||/items/366393f3-d1f1-4c58-84b1-89b43ca5b522 Fraile, A. (A.)|||/items/802cca22-d87a-45a9-a20a-af3b9861beb5 Carrasco, J. (J.L.)|||/items/d41251ca-1836-4195-90fa-055c1f44f330 Sole, F. (Francesc)|||/items/f2e2b40d-3895-49b7-a41a-9f01a078406d Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6 Gullon, A. (Arturo)|||/items/ca7ff744-c2e8-470e-952a-70bd1d9e66bf |
| author_role |
author |
| author2 |
Cigudosa, J.C. (Juan Cruz)|||/items/81ac2a66-7c9e-4a8d-b44b-92f7552c954a Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251 Ferreira, C. (C.)|||/items/e7b44101-8501-434c-84ea-ac41fed371a9 Ardanaz, M.T. (M.T.)|||/items/366393f3-d1f1-4c58-84b1-89b43ca5b522 Fraile, A. (A.)|||/items/802cca22-d87a-45a9-a20a-af3b9861beb5 Carrasco, J. (J.L.)|||/items/d41251ca-1836-4195-90fa-055c1f44f330 Sole, F. (Francesc)|||/items/f2e2b40d-3895-49b7-a41a-9f01a078406d Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6 Gullon, A. (Arturo)|||/items/ca7ff744-c2e8-470e-952a-70bd1d9e66bf |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Chromosome Aberrations Chromosome Disorders Multiple Myeloma/genetics |
| topic |
Chromosome Aberrations Chromosome Disorders Multiple Myeloma/genetics |
| description |
Cytogenetic analysis of unstimulated short-term bone marrow cell cultures was performed on 280 patients with multiple myeloma and related disorders. In 65% of the cases, an additional short term B-cell stimulated culture was also examined. Chromosomally abnormal clones were found in 31% of the patients, 15% in Waldenström macroglobulinemia. 25% in monoclonal gammopathies, 33% in multiple myeloma, and 50% in plasma cell leukemia. Three primary chromosomal breakpoints were recurrently involved: 14q32, 16q22, and 22q11. Structural rearrangements of chromosome 1 were the most frequent (26% of the abnormal cases), but always as a secondary change. Rearrangements of band 14q32 were found in 22% of the abnormal cases. Among the multiple myeloma patients who showed an abnormal karyotype, 33 (46%) were hyperdiploid, most frequently, with 52-56 chromosomes, 29 patients (40%) were pseudodiploid, and the remaining 12 cases (14%) were hypodiploid. A highly significant relation was observed between the presence of an abnormal karyotype and the following clinical parameters: stage III (P = 0.0001), bone marrow plasma cell infiltration greater than 30% (P = 0.0001), presence of bone lesions (P = 0.0009), and beta 2-microglobulin levels greater than 4 mg/L (P = 0.0001). |
| publishDate |
1997 |
| dc.date.none.fl_str_mv |
1997 1997-01-01 1997 1997-01-01 2011 2011-11-15 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/19794 |
| url |
https://hdl.handle.net/10171/19794 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
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Wiley-Blackwell |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869425121628782592 |
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15,300719 |