Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations

Cytogenetic analysis of unstimulated short-term bone marrow cell cultures was performed on 280 patients with multiple myeloma and related disorders. In 65% of the cases, an additional short term B-cell stimulated culture was also examined. Chromosomally abnormal clones were found in 31% of the patie...

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Detalles Bibliográficos
Autores: Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086, Cigudosa, J.C. (Juan Cruz)|||/items/81ac2a66-7c9e-4a8d-b44b-92f7552c954a, Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251, Ferreira, C. (C.)|||/items/e7b44101-8501-434c-84ea-ac41fed371a9, Ardanaz, M.T. (M.T.)|||/items/366393f3-d1f1-4c58-84b1-89b43ca5b522, Fraile, A. (A.)|||/items/802cca22-d87a-45a9-a20a-af3b9861beb5, Carrasco, J. (J.L.)|||/items/d41251ca-1836-4195-90fa-055c1f44f330, Sole, F. (Francesc)|||/items/f2e2b40d-3895-49b7-a41a-9f01a078406d, Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6, Gullon, A. (Arturo)|||/items/ca7ff744-c2e8-470e-952a-70bd1d9e66bf
Tipo de recurso: artículo
Fecha de publicación:1997
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/19794
Acceso en línea:https://hdl.handle.net/10171/19794
Access Level:acceso abierto
Palabra clave:Chromosome Aberrations
Chromosome Disorders
Multiple Myeloma/genetics
Descripción
Sumario:Cytogenetic analysis of unstimulated short-term bone marrow cell cultures was performed on 280 patients with multiple myeloma and related disorders. In 65% of the cases, an additional short term B-cell stimulated culture was also examined. Chromosomally abnormal clones were found in 31% of the patients, 15% in Waldenström macroglobulinemia. 25% in monoclonal gammopathies, 33% in multiple myeloma, and 50% in plasma cell leukemia. Three primary chromosomal breakpoints were recurrently involved: 14q32, 16q22, and 22q11. Structural rearrangements of chromosome 1 were the most frequent (26% of the abnormal cases), but always as a secondary change. Rearrangements of band 14q32 were found in 22% of the abnormal cases. Among the multiple myeloma patients who showed an abnormal karyotype, 33 (46%) were hyperdiploid, most frequently, with 52-56 chromosomes, 29 patients (40%) were pseudodiploid, and the remaining 12 cases (14%) were hypodiploid. A highly significant relation was observed between the presence of an abnormal karyotype and the following clinical parameters: stage III (P = 0.0001), bone marrow plasma cell infiltration greater than 30% (P = 0.0001), presence of bone lesions (P = 0.0009), and beta 2-microglobulin levels greater than 4 mg/L (P = 0.0001).

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