Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

Prats, Anna|||0000-0002-3586-4525; Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284; Mothe, Beatriz|||0000-0001-9975-407X; Negredo Puigmal, Eugènia|||0000-0001-5298-1734; Pérez-Álvarez, Núria|||0000-0001-6582-1553; Garolera, Maite; Domenech, Sira|||0000-0002-5700-768X; Coll, Pep; Meulbroek, Michael; Chamorro, Anna; Fumaz, Carmina R.|||0000-0003-0838-3395; Ferrer, Maria Jose; Clotet Sala, Bonaventura|||0000-0003-3232-4598; Soriano-Mas, Carles|||0000-0003-4574-6597; Muñoz-Moreno, José Antonio|||0000-0002-7239-5422

Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the e...

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Autores:	Prats, Anna\|\|\|0000-0002-3586-4525, Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284, Mothe, Beatriz\|\|\|0000-0001-9975-407X, Negredo Puigmal, Eugènia\|\|\|0000-0001-5298-1734, Pérez-Álvarez, Núria\|\|\|0000-0001-6582-1553, Garolera, Maite, Domenech, Sira\|\|\|0000-0002-5700-768X, Coll, Pep, Meulbroek, Michael, Chamorro, Anna, Fumaz, Carmina R.\|\|\|0000-0003-0838-3395, Ferrer, Maria Jose, Clotet Sala, Bonaventura\|\|\|0000-0003-3232-4598, Soriano-Mas, Carles\|\|\|0000-0003-4574-6597, Muñoz-Moreno, José Antonio\|\|\|0000-0002-7239-5422
Tipo de recurso:	artículo
Fecha de publicación:	2021
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:255608
Acceso en línea:	https://ddd.uab.cat/record/255608 https://dx.doi.org/urn:doi:10.1038/s41598-021-90678-6
Access Level:	acceso abierto
Palabra clave:	Infectious diseases Cognitive neuroscience Anxiety Depression Central nervous system infections

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spelling	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infectionPrats, Anna\|\|\|0000-0002-3586-4525Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284Mothe, Beatriz\|\|\|0000-0001-9975-407XNegredo Puigmal, Eugènia\|\|\|0000-0001-5298-1734Pérez-Álvarez, Núria\|\|\|0000-0001-6582-1553Garolera, MaiteDomenech, Sira\|\|\|0000-0002-5700-768XColl, PepMeulbroek, MichaelChamorro, AnnaFumaz, Carmina R.\|\|\|0000-0003-0838-3395Ferrer, Maria JoseClotet Sala, Bonaventura\|\|\|0000-0003-3232-4598Soriano-Mas, Carles\|\|\|0000-0003-4574-6597Muñoz-Moreno, José Antonio\|\|\|0000-0002-7239-5422Infectious diseasesCognitive neuroscienceAnxietyDepressionCentral nervous system infectionsIntegrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the effects of INSTI-based antiretroviral therapy on comprehensive brain outcomes (cognitive, functional, and imaging) according to the time since HIV-1 acquisition. We recruited men living with HIV who initiated antiretroviral therapy with INSTI < 3 months since the estimated date of HIV-1 acquisition (n = 12) and.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255608https://dx.doi.org/urn:doi:10.1038/s41598-021-90678-6reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 CPII16/00048Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MTM2015-64465-C2-1-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2556082026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
spellingShingle	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection Prats, Anna\|\|\|0000-0002-3586-4525 Infectious diseases Cognitive neuroscience Anxiety Depression Central nervous system infections
title_short	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_full	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_fullStr	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_full_unstemmed	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_sort	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
dc.creator.none.fl_str_mv	Prats, Anna\|\|\|0000-0002-3586-4525 Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284 Mothe, Beatriz\|\|\|0000-0001-9975-407X Negredo Puigmal, Eugènia\|\|\|0000-0001-5298-1734 Pérez-Álvarez, Núria\|\|\|0000-0001-6582-1553 Garolera, Maite Domenech, Sira\|\|\|0000-0002-5700-768X Coll, Pep Meulbroek, Michael Chamorro, Anna Fumaz, Carmina R.\|\|\|0000-0003-0838-3395 Ferrer, Maria Jose Clotet Sala, Bonaventura\|\|\|0000-0003-3232-4598 Soriano-Mas, Carles\|\|\|0000-0003-4574-6597 Muñoz-Moreno, José Antonio\|\|\|0000-0002-7239-5422
author	Prats, Anna\|\|\|0000-0002-3586-4525
author_facet	Prats, Anna\|\|\|0000-0002-3586-4525 Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284 Mothe, Beatriz\|\|\|0000-0001-9975-407X Negredo Puigmal, Eugènia\|\|\|0000-0001-5298-1734 Pérez-Álvarez, Núria\|\|\|0000-0001-6582-1553 Garolera, Maite Domenech, Sira\|\|\|0000-0002-5700-768X Coll, Pep Meulbroek, Michael Chamorro, Anna Fumaz, Carmina R.\|\|\|0000-0003-0838-3395 Ferrer, Maria Jose Clotet Sala, Bonaventura\|\|\|0000-0003-3232-4598 Soriano-Mas, Carles\|\|\|0000-0003-4574-6597 Muñoz-Moreno, José Antonio\|\|\|0000-0002-7239-5422
author_role	author
author2	Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284 Mothe, Beatriz\|\|\|0000-0001-9975-407X Negredo Puigmal, Eugènia\|\|\|0000-0001-5298-1734 Pérez-Álvarez, Núria\|\|\|0000-0001-6582-1553 Garolera, Maite Domenech, Sira\|\|\|0000-0002-5700-768X Coll, Pep Meulbroek, Michael Chamorro, Anna Fumaz, Carmina R.\|\|\|0000-0003-0838-3395 Ferrer, Maria Jose Clotet Sala, Bonaventura\|\|\|0000-0003-3232-4598 Soriano-Mas, Carles\|\|\|0000-0003-4574-6597 Muñoz-Moreno, José Antonio\|\|\|0000-0002-7239-5422
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Infectious diseases Cognitive neuroscience Anxiety Depression Central nervous system infections
topic	Infectious diseases Cognitive neuroscience Anxiety Depression Central nervous system infections
description	Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the effects of INSTI-based antiretroviral therapy on comprehensive brain outcomes (cognitive, functional, and imaging) according to the time since HIV-1 acquisition. We recruited men living with HIV who initiated antiretroviral therapy with INSTI < 3 months since the estimated date of HIV-1 acquisition (n = 12) and.
publishDate	2021
dc.date.none.fl_str_mv	2 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/255608 https://dx.doi.org/urn:doi:10.1038/s41598-021-90678-6
url	https://ddd.uab.cat/record/255608 https://dx.doi.org/urn:doi:10.1038/s41598-021-90678-6
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CPII16/00048 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MTM2015-64465-C2-1-R
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

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