Markers of endothelial damage in patients with chronic kidney disease on hemodialysis

Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, a...

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Autores: Carmona, Andrés, Agüera, Maria L., Luna-Ruiz, Carlos, Buendía, Paula, Calleros-Basilio, Laura, García-Jerez, Andrea, Rodríguez-Puyol, Manuel, Arias, Manuel, Arias-Guillen, Marta, Arriba, Gabriel de, Ballarín, José, Bernis, Carmen, Fernández i Giráldez, Elvira, García-Rebollo, Sagrario, Mancha, Javier, Peso, Gloria del, Pérez, Estefanía, Poch, Esteban, Portolés, José M., Rodríguez-Puyol, Diego, Sánchez-Villanueva, Rafael, Sarró, Felipe, Torres, Armando, Martín-Malo, Alejandro, Aljama, Pedro, Ramírez, Rafael, Carracedo, Júlia
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/64518
Acceso en línea:https://doi.org/10.1152/ajprenal.00013.2016
http://hdl.handle.net/10459.1/64518
Access Level:acceso abierto
Palabra clave:Chronic kidney disease
Cardiovascular disease
Diabetes mellitus
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spelling Markers of endothelial damage in patients with chronic kidney disease on hemodialysisCarmona, AndrésAgüera, Maria L.Luna-Ruiz, CarlosBuendía, PaulaCalleros-Basilio, LauraGarcía-Jerez, AndreaRodríguez-Puyol, ManuelArias, ManuelArias-Guillen, MartaArriba, Gabriel deBallarín, JoséBernis, CarmenFernández i Giráldez, ElviraGarcía-Rebollo, SagrarioMancha, JavierPeso, Gloria delPérez, EstefaníaPoch, EstebanPortolés, José M.Rodríguez-Puyol, DiegoSánchez-Villanueva, RafaelSarró, FelipeTorres, ArmandoMartín-Malo, AlejandroAljama, PedroRamírez, RafaelCarracedo, JúliaChronic kidney diseaseCardiovascular diseaseDiabetes mellitusPatients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins (Ang) to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (Madrid, Spain): 80 patients with DM and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD142+/CD16+, CD14+/CD162+) were analyzed by flow cytometry, and the plasma concentrations of Ang1 and Ang2 were quantified by ELISA. Data on CVD were gathered over the 5.5 yr after these samples were obtained. MV level, monocyte subpopulations (CD14+/CD162+ and CD142+/CD16+), and Ang2-to-Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/µl) was associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2-to-Ang1 ratio can be used as predictors for CVD. In addition, MV level has a potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM.Support for this work was provided by Plan Nacional de IDi Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)–Subdirección General de Evaluación, Fondos de desarrollo regional (FEDER; PI11/01536, PI12/01489, PI14/00806, PI15/01785); Junta de Andalucía grants (P010-CTS-6337, P11-CTS-7352); and Fundación Nefrológica. P. Buendía, A. Carmona, and C. Luna-Ruiz are fellows from Consejería de Innovacion, Ciencia y Empresa, Junta de Andalucía.American Physiological Society2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1152/ajprenal.00013.2016http://hdl.handle.net/10459.1/64518reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió postprint del document publicat a: https://doi.org/10.1152/ajprenal.00013.2016American Journal of Physiology-Renal Physiology, 2017, vol. 312, núm. 4, p. 673-681(c) The American Physiological Society, 2017info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/645182026-06-24T12:42:17Z
dc.title.none.fl_str_mv Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
title Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
spellingShingle Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
Carmona, Andrés
Chronic kidney disease
Cardiovascular disease
Diabetes mellitus
title_short Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
title_full Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
title_fullStr Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
title_full_unstemmed Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
title_sort Markers of endothelial damage in patients with chronic kidney disease on hemodialysis
dc.creator.none.fl_str_mv Carmona, Andrés
Agüera, Maria L.
Luna-Ruiz, Carlos
Buendía, Paula
Calleros-Basilio, Laura
García-Jerez, Andrea
Rodríguez-Puyol, Manuel
Arias, Manuel
Arias-Guillen, Marta
Arriba, Gabriel de
Ballarín, José
Bernis, Carmen
Fernández i Giráldez, Elvira
García-Rebollo, Sagrario
Mancha, Javier
Peso, Gloria del
Pérez, Estefanía
Poch, Esteban
Portolés, José M.
Rodríguez-Puyol, Diego
Sánchez-Villanueva, Rafael
Sarró, Felipe
Torres, Armando
Martín-Malo, Alejandro
Aljama, Pedro
Ramírez, Rafael
Carracedo, Júlia
author Carmona, Andrés
author_facet Carmona, Andrés
Agüera, Maria L.
Luna-Ruiz, Carlos
Buendía, Paula
Calleros-Basilio, Laura
García-Jerez, Andrea
Rodríguez-Puyol, Manuel
Arias, Manuel
Arias-Guillen, Marta
Arriba, Gabriel de
Ballarín, José
Bernis, Carmen
Fernández i Giráldez, Elvira
García-Rebollo, Sagrario
Mancha, Javier
Peso, Gloria del
Pérez, Estefanía
Poch, Esteban
Portolés, José M.
Rodríguez-Puyol, Diego
Sánchez-Villanueva, Rafael
Sarró, Felipe
Torres, Armando
Martín-Malo, Alejandro
Aljama, Pedro
Ramírez, Rafael
Carracedo, Júlia
author_role author
author2 Agüera, Maria L.
Luna-Ruiz, Carlos
Buendía, Paula
Calleros-Basilio, Laura
García-Jerez, Andrea
Rodríguez-Puyol, Manuel
Arias, Manuel
Arias-Guillen, Marta
Arriba, Gabriel de
Ballarín, José
Bernis, Carmen
Fernández i Giráldez, Elvira
García-Rebollo, Sagrario
Mancha, Javier
Peso, Gloria del
Pérez, Estefanía
Poch, Esteban
Portolés, José M.
Rodríguez-Puyol, Diego
Sánchez-Villanueva, Rafael
Sarró, Felipe
Torres, Armando
Martín-Malo, Alejandro
Aljama, Pedro
Ramírez, Rafael
Carracedo, Júlia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chronic kidney disease
Cardiovascular disease
Diabetes mellitus
topic Chronic kidney disease
Cardiovascular disease
Diabetes mellitus
description Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins (Ang) to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (Madrid, Spain): 80 patients with DM and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD142+/CD16+, CD14+/CD162+) were analyzed by flow cytometry, and the plasma concentrations of Ang1 and Ang2 were quantified by ELISA. Data on CVD were gathered over the 5.5 yr after these samples were obtained. MV level, monocyte subpopulations (CD14+/CD162+ and CD142+/CD16+), and Ang2-to-Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/µl) was associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2-to-Ang1 ratio can be used as predictors for CVD. In addition, MV level has a potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1152/ajprenal.00013.2016
http://hdl.handle.net/10459.1/64518
url https://doi.org/10.1152/ajprenal.00013.2016
http://hdl.handle.net/10459.1/64518
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1152/ajprenal.00013.2016
American Journal of Physiology-Renal Physiology, 2017, vol. 312, núm. 4, p. 673-681
dc.rights.none.fl_str_mv (c) The American Physiological Society, 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) The American Physiological Society, 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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