Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases

Interleukins are central in the modulation of immune responses. This narra-tive review aims to summarize the growing evidence on their significance askey drivers of numerous cutaneous diseases with a special focus in some of themore prevalent chronic inflammatory dermatologic diseases such as psoria...

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Detalles Bibliográficos
Autores: Prados-Carmona, Alvaro, Navarro-Triviño, Francisco J., Ruiz-Villaverde, Ricardo, Corell-Almuzara, Alfredo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/174790
Acceso en línea:https://hdl.handle.net/11441/174790
https://doi.org/10.1002/jvc2.537
Access Level:acceso abierto
Palabra clave:Cytokines
Dermatology
Interleukins
Pathogenesis
Targeted therapies
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spelling Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseasesPrados-Carmona, AlvaroNavarro-Triviño, Francisco J.Ruiz-Villaverde, RicardoCorell-Almuzara, AlfredoCytokinesDermatologyInterleukinsPathogenesisTargeted therapiesInterleukins are central in the modulation of immune responses. This narra-tive review aims to summarize the growing evidence on their significance askey drivers of numerous cutaneous diseases with a special focus in some of themore prevalent chronic inflammatory dermatologic diseases such as psoriasis,atopic dermatitis, allergic contact dermatitis, urticaria, and hidradenitis sup-purativa. Additionally, we discuss their relevance in the recent developmentsin targeted therapies that have significantly transformed the management ofthese skin conditions. To this end, we have conducted a comprehensive searchthrough the Cochrane Library and Database of Systematic Reviews and theMEDLINE search engine, and we have summarized the available clinicalevidence considering up to 466 records including meta‐analyses, systematicreviews, reviews and clinical trials. Ultimately, this review intents to fosterboth dermatologist and non‐dermatologist physicians' understanding of theimmunology behind the clinical manifestations of some of the most commoninflammatory skin diseases and engage with the novel therapeutic approachesby providing accessible insights into the implications of interleukin pathwaysdysregulation.WileyBioquímica Médica y Biología Molecular e InmunologíaCTS1074: Inmunonutrición e Inmunometabolismo2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/174790https://doi.org/10.1002/jvc2.537reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJEADV Clinical Practice, 3 (5), 1381-1398.https://onlinelibrary.wiley.com/doi/10.1002/jvc2.537info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1747902026-06-17T12:51:07Z
dc.title.none.fl_str_mv Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
title Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
spellingShingle Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
Prados-Carmona, Alvaro
Cytokines
Dermatology
Interleukins
Pathogenesis
Targeted therapies
title_short Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
title_full Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
title_fullStr Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
title_full_unstemmed Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
title_sort Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases
dc.creator.none.fl_str_mv Prados-Carmona, Alvaro
Navarro-Triviño, Francisco J.
Ruiz-Villaverde, Ricardo
Corell-Almuzara, Alfredo
author Prados-Carmona, Alvaro
author_facet Prados-Carmona, Alvaro
Navarro-Triviño, Francisco J.
Ruiz-Villaverde, Ricardo
Corell-Almuzara, Alfredo
author_role author
author2 Navarro-Triviño, Francisco J.
Ruiz-Villaverde, Ricardo
Corell-Almuzara, Alfredo
author2_role author
author
author
dc.contributor.none.fl_str_mv Bioquímica Médica y Biología Molecular e Inmunología
CTS1074: Inmunonutrición e Inmunometabolismo
dc.subject.none.fl_str_mv Cytokines
Dermatology
Interleukins
Pathogenesis
Targeted therapies
topic Cytokines
Dermatology
Interleukins
Pathogenesis
Targeted therapies
description Interleukins are central in the modulation of immune responses. This narra-tive review aims to summarize the growing evidence on their significance askey drivers of numerous cutaneous diseases with a special focus in some of themore prevalent chronic inflammatory dermatologic diseases such as psoriasis,atopic dermatitis, allergic contact dermatitis, urticaria, and hidradenitis sup-purativa. Additionally, we discuss their relevance in the recent developmentsin targeted therapies that have significantly transformed the management ofthese skin conditions. To this end, we have conducted a comprehensive searchthrough the Cochrane Library and Database of Systematic Reviews and theMEDLINE search engine, and we have summarized the available clinicalevidence considering up to 466 records including meta‐analyses, systematicreviews, reviews and clinical trials. Ultimately, this review intents to fosterboth dermatologist and non‐dermatologist physicians' understanding of theimmunology behind the clinical manifestations of some of the most commoninflammatory skin diseases and engage with the novel therapeutic approachesby providing accessible insights into the implications of interleukin pathwaysdysregulation.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/174790
https://doi.org/10.1002/jvc2.537
url https://hdl.handle.net/11441/174790
https://doi.org/10.1002/jvc2.537
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv JEADV Clinical Practice, 3 (5), 1381-1398.
https://onlinelibrary.wiley.com/doi/10.1002/jvc2.537
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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